Drug Repositioning: An Effective Approach in Drug Development

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• Drug Repositioning An Effective Approach in
  Drug Development
• High cost and low pace of traditional drug
  discovery and development process have shifted
  the interest of major pharma companies towards
  finding new use of already existing drugs. Drug-
  repositioning is creating a buzz specially in
  rare and neglected diseases as it decreases the
  overall cost of bring a drug to the market.
  Repurposing is based on observations, existing
  disease information, pathways, targets, ligands,
  drugs pleiotropic effect. Utilization of already
  existing drugs for new diseases is cost
  effective and time saving since pharmacology,
  safety, toxicity, and formulation profiles of
  these drugs are already established.
• Benefits of Drug-Repositioning
• The drug-repositioning is an important lever for
  pharma companies to improve RD productivity and
  enables RD teams to
• Fast-track development and reduces risk -
  Repositioning can reduce drug development
  process from the typical 10-17 years for a de
  novo drug to 3-12 years (Exhibit 1). Further,
  this lowers risk because the molecules
  pharmacokinetic and safety profile are already
  known.
• Increase revenue and return-on-investment -
  Repositioning can characterize more profitable
  indications and recover abandoned projects.
• Expand IP Protection- New uses for an existing
  molecule can result in extended patent
  protection, depending on the level of novelty and
  whether any reformulation is involved. Further,
  proactively recognizing indication expansion
  opportunities earlier in development process can
  result in achieving greater revenue during the
  period of exclusivity
• For the complete informative article on the Drug
  Repositioning, please visit _at_
• https//www.iebrain.com/drug-repositioning-an-effe
  ctive-approach-in-drug-development/
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