Free curcuminoid | Curcumin for Joint Health

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CURQFEN - RISING TO NEW HEIGHTS IN FREE
CURCUMINOIDS DELIVERY
www.curqfen.net
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CurQfen - Rising to new heights in free
curcuminoids delivery
A large number of in-vitro studies have revealed
intriguing pharmacodynamics of curcumin as a
neuroprotective agent, specifically confirming
the modulation of genes, proteins, transcription
factors, and neurotransmitters at the
mitochondrial level in support of curcumins
possible positive influence on various brain
health functions like neuro inflammation,
neurodegenerative etc. The real challenge is
delivering the free form of curcumin
(unconjugated form) to the targeted brain
tissues. The native form of curcumin is BBB
permeable. But once it has undergone
biotransformation (metabolized into glucuronides)
the ability to pass the barrier is lost since the
conjugated metabolites are bulky water-soluble
molecules and undergoes quick renal
clearance. Another point to be noted is that
consumption of high dosage of unformulated
curcumin 95 has shown to deliver some amount
unconjugated free forms (less than 10 ng/g level)
to the brain tissues when analyzed by sensitive
tandem mass spectrometric tools. Thus, any
formulation having unformulated curcumin 95 can
deliver trace amount of neuro protection,
provided if we consume high dosage and the
effects will be quite marginal. Here comes the
real-world significance of a formulation which
can deliver significant amount of free
curcuminoids to the brain tissue without having
the burden of high dose. CurQfen was the
solution for this dilemma. CurQfen, a new
generation curcumin for brain health joint
health which is a green formulation of curcumin
and de-bitter fenugreek fibre as self-emulsifying
hydrogel scaffold, is capable of delivering high
level of BBB-permeable free curcumin even at a
low dosage of 250mg single dose (Kumar et al.,
2016).