Metformin – The most common and famous prescribed medicine - PowerPoint PPT Presentation
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Metformin – The most common and famous prescribed medicine
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Diabetes or high blood sugar today has become as common issue in every family life. Without even realizing we can manage diabetes, if we accept it easily. There is a phase between our normal blood sugar and prediabetes. So, during prediabetes if we start medications along with diet management and increase level of activity, we can really delay any complications for 30 to 40 years. Whenever we think of diabetes, kidney failure and insulin are two factors. Kidney failure is not the only thing. We can become blind or have heart attack. We can lose sensations in our feet leading to amputation of our legs. – PowerPoint PPT presentation
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Title: Metformin – The most common and famous prescribed medicine
1
Metformin The most common and famous prescribed
medicine
Add15years.com Add15years.in Author (Prof.) Dr.
S. Om Goel, MD/DM From family of doctors from
AIIMS, MAMC Delhi University MD Medicine,
USA DM/Fellowship, USA
2
Metformin The most common and famous prescribed
medicine
- Metformin (1,1-dimethylbiguanide), a biguanide
derivate and its chemical structure is related to
guanidine. - Insulin sensitizer
- Most widely prescribed drug to treat
hyperglycemia, at least 120 million user
worldwide. - Monotherapy in combination with all
antidiabetic.
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History
- Metformin was first prepared in 1922 by the
Dublin chemists - Jean sterne wasthe first to try metformin on
humans for the treatment of diabetes. - He coined the name Glucophage for the drug and
published his results in 1957. - Metformin was introduced to the United Kingdom in
1958, France in 1957, and Canada in 1972.
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Popular Brands
- Glucophage
- Metformin Hydrochloride ER
- Glumetza
- Rioment
- Fortamet
- Glucophage XR
- Diamin
- Formin
- Met 500
- Bigomet
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Mechanism of action
Decrease hepatic glucose production
through a mild inhibitions of the mitochondrial
respiratory-chain. Decrease intestinal
absorption of glucose. Anti-oxidative properties
of metformin on endothelial cells
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Actions of metformin
- Anti-obesity effects
- Decreased appetite
- Increased GLP-1 sections
- Anti-hyperglycemic effects
- Decreased intestinal carbohydrate absorption
- Inhibition of hepatic gluconeogenesis
- Enhancement of insulin-stimulated glucose
transport in the skeletal muscle.
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Side Effect
- Metallic taste in the mouth
- Gastrointestinal (anorexia, cough, vomiting,
abdominal discomfort) - Vitamin B12 deficiency
- Lactic acidosis
- Reduce appetite
- Fatigue
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Author (Prof.) Dr. S. Om Goel, MD/DM From family
of doctors from AIIMS, MAMC Delhi University
MD Medicine, USA DM/Fellowship, USA
www.add15years.com www.add15years.in
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