Umbilical cord preservation – a hypothetical field

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Umbilical Cord Preservation A Hypothetical
Field

• Advantages of Umbilical Cord Stem Cells, Stem
  Cell Banking Benefits

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Umbilical Cord Preservation A Hypothetical Field

• Previously umbilical cord blood was considered as
  medical waste and thrown away along with the
  placenta after the birth of the baby.
• With various advancements in the medical field,
  the cord blood has been discovered as a rich
  source of hematopoietic stem cells that can save
  the life of a person.
• The reason behind is stem cells are having the
  ability to regenerate into any kind of cells or
  tissues.

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Umbilical Cord Preservation A Hypothetical Field

• UCB collected from the umbilical cord differs in
  its properties from the peripheral blood.
• It is a rich source of hematopoietic stem cells
  with self-renewal properties and the ability to
  differentiate into myeloid and lymphoid cell
  lines.
• DNA has a longer telomer in these cells, which
  helps with long-term hematopoiesis.
• Cord blood is also a rich source of mesenchymal
  cells that are known to suppress
  Graft-versus-host disease (GVHD) response and
  have naive T cells with minimal foreign antigen
  recognition.

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Umbilical Cord Preservation A Hypothetical Field

• The use of UCB as a source of stem cells in HSCT
  has successfully exploited these properties of
  cord blood cells in the treatment of various
  malignant, hematological and storage disorders.
• With the efficient recovery of stem cells on
  thawing, UCB can be cryopreserved and stored for
  more than 15 years.

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Umbilical Cord Preservation A Hypothetical Field

• Cord Blood is collected after the infant leaves
  the body of the mother and the umbilical cord is
  cut so that the process of collecting cord blood
  for both mother and infant is absolutely safe and
  painless.
• The amount of cord blood depends on placenta size
  and umbilical cord thickness, for Asian, it is
  about 60ml on average.
• Each drop of cord blood is rich in stem cells, so
  doctors will try to collect as much cord blood as
  they can.

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Umbilical Cord Preservation A Hypothetical Field

• It is very simple to collect the cord blood from
  the umbilical cord. At first, the blood from the
  umbilical cord is extracted from the cord
  attached to the placenta by means of a needle.
• Then the blood is collected with the collection
  kit in a bag. It was then sent for processing to
  the laboratory, which must be completed within 48
  hours. The sample is then tested and frozen in
  the laboratory.

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Umbilical Cord Preservation A Hypothetical Field

• The role of cord stem cells in regenerative
  medicine is still under investigation and the
  benefits are largely hypothetical in this
  respect.
• Regenerative medicine is a medical field
  dedicated to treatments that induce stem cells to
  differentiate into the specific type of cells to
  repair damaged or destroyed cells or tissues.
• This' stem cell therapy' is different from HSCT
  and is an experimental treatment rather than a
  standard.

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Umbilical Cord Preservation A Hypothetical Field

• Stem cell therapy's role in conditions including
  diabetes mellitus, neurological conditions (such
  as cerebral paralysis, birth asphyxia, spinal
  cord injury) and myocardial infarction is still
  at the level of preclinical studies (in animals)
  or clinical studies in phase I / II.
• Hence some of the medical experts still do not
  recommend for stem cell therapy in these
  conditions.
• However, the cord blood collection will help in
  the extraction of the stem cells and with
  different advancements, in the transplantation of
  the cord blood, many of the patients are nowadays
  able to find the donor whose HLA is matched.