Role of Zoledronic acid in treating Prostate Cancer

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Role of Zoledronic Acid In Advanced Prostate
Cancer
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Zoledronic acid more commonly known as Reclast,
Aclasta or Zometa. This medication works by
slowing down osteoclast i.e. bone cells. These
osteoclasts generally break down the hard-mineral
structure of the bones in order to keep the bones
healthy. But when the prostate cancer spreads
to bones, these osteoclasts become overactive
which cause problems in the body.
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Uses for Reclast infusion (generic Zoledronic
Acid) Relieving high calcium levels and
increased pain caused due to cancer which has
spread to the bones. Reducing the growth of
cancer cells spread to bones. And also helps in
delay/prevent fractures. Strengthening of bones
in Males who are currently receiving hormone
therapy.
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Zoledronic Acid Cost Information Zoledronic acid
injection (Brand Zometa) is most commonly used
medication for prostate cancer. Zometa /
Reclast is generally given once every 3 or 4
weeks as an intravenous injection. This
medication if given to men are required to take
calcium supplement and Vitamin D in order to
avoid any problem related to low calcium levels.
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• Some common Reclast Side effects are
• Nausea and Vomiting
• Loss of appetite
• Flu-like symptoms
• Kidney problems
• Increase in pain in muscles, bone or joints.
• Red, sore or itchy eyes.
• Problems in stomach or bowel.

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• Some rare Zoledronic Acid side effects
• Rashes or itching on the skin
• Increased risk of strokes and heart problems
• Jaw bone problems i.e. Osteonecrosis of the jae
• Reclast Cost Information
• Clinical trial proving Zoledronic Acid infusion
  efficacy

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Between 2003 and 2007, a study was conducted by
recruiting 1071 men who were suffering from
advanced prostate cancer. And all the
recruitees were randomly divided into 4 groups.
Group 1 was given leuprorelin for 6 months and it
was the control group Group 2 was given
leuprorelin for 18 months, Group 3 was given
leuprorelin for 6 months and zoledronic acid for
18 months and Group 4 was given leuprorelin for
18 months plus zoledronic acid for 18 months.
All the persons were given radiotherapy for 5
months after being divided into groups.
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After the 3-year follow up it was observed that,
zoledronic acid taken for 18 months could
decrease osteopenia, and that androgen
suppression taken for nearly 18 months didnt
increase the vertebral fractures in the patients.
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The study was carried out for 7.4 years, during
which 91 patients died of prostate cancer. It
was observed that there wasnt any difference
between the control and experimental groups
all-cause mortality or cancer mortality rate.
But it was shown that difference seemed to
occur on the basis of Gleason score. Patients
with Gleason score of 8 10 benefitted the most
as relapsed rate had reduced by 40. Patients
with Gleason score of 7 or below, there relapse
rate was less than 30 with androgen suppression.
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According to the study, Zoledronic acid could
protect against prostate cancer cells residing in
the bone marrow from the androgen
suppression.    The information provided on the
page is meant for the purpose of being helpful
and educational. It should not be considered as
medical advice.
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