Bendamustine treatment for Multiple Myeloma

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Bendamustine Treatment For Multiple Myeloma
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Bendamustine is used as an effective fir-line
treatment for heavily pre-treated relapsed
patients and multiple myeloma (MM) patients.
The combination therapy of Treanda (generic
Bendamustine) with other drugs like Rituximab are
considered when all the other treatment options
have been exhausted.
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Who is at risk for developing Multiple
Myeloma Bendamustine rituximab treatment is very
effective in treatment of multiple myeloma.
Multiple myeloma is a plasma cell neoplasm
which is categorised by the build-up of clonal
bone marrow plasma cells that produces an
abnormal monoclonal immunoglobin which can be
detected in either urine or blood. Multiple
myeloma is held responsible for almost 10 of all
hematologic malignancies.
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Since the approval of Treanda (generic
Bendamustine) in 2011, this drug has proved to be
very viable treatment option for the patients who
are suffering with refractory or relapsed
multiple myeloma. Bendamustine cost information
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Bendamustine Mechanism of Action A bi-functional
alkylating agent with structural resemblances to
both purine analogues and alkylating agents,
bendamustine induces anti-tumor effects by
causing inter- and intra-strand cross-links
between DNA bases that are more extensive and
durable than those caused by other alkylating
agents. Thus, bendamustine displays incomplete
cross-resistance with melphalan and
cyclophosphamide.
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Patient characteristics During a recent study
conducted in Korea between November 2011 and
September 2013, a total of 65 patients were
selected at random who would receive bendamustine
treatment. There were 36 patients who were
diagnosed with multiple myeloma who underwent
ASCT after induction treatment. The median for
previous treatments was 5 year and median for
bendamustine treatment was 3.8 years. And as a
result, the median age was 63 years for the first
time of bendamustine treatment. And a substantial
number of patients who received bendamustine
treatment had a advanced disease with bone marrow
function and impairment of renal.
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• Bendamustine side effects
• Some Common Side Effects Of Using Treanda
  (Generic Bendamustine) Were
• Joint Pain, Stiffness, Or Swelling
• Black, Tarry Stools
• Chest Pain
• Bleeding Gums
• Blood In The Urine Or Stools
• Chills
• Cough Or Hoarseness
• Diarrhea
• Fever
• Headache

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• Lack Or Loss Of Strength
• Lower Back, Side, Or Stomach Pain
• Sore Throat
• Muscle Aches
• Nausea
• Painful Or Difficult Urination
• Pale Skin
• Pinpoint Red Spots On The Skin
• Ulcers, Sores, Or White Spots In The Mouth
• Stuffy Or Runny Nose

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• Swelling Of The Feet Or Lower Legs
• Swollen Glands
• Troubled Breathing With Exertion
• Unusual Bleeding Or Bruising
• Unusual Tiredness Or Weakness
• Vomiting
• The Above Side Effects Were Also Faced By The
  Patients Were Enrolled In The Study.

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Survival outcome The median of Overall survival
was 5.5 months and Progression free survival
after the bendamustine treatment was 3.1 months.
Although the median was very short, but there
were a total of 14 patients who lived longer than
12 months after starting with bendamustine
treatment. The overall survival in recruited
patients who responded with bendamustine was
significantly higher than those who didnt
respond to the treatment.
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The performance status of the patients was
significantly linked to the Overall Survival and
improved Overall survival was also observed among
the patients who were less than 60 years.
However, the median treatments lines prior to
the treatment with bendamustine was not all
linked to overall survival.
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Bendamustine / Treanda cost information The
information provided on the page is meant for the
purpose of being helpful and educational. It
should not be considered as medical
advice. bendamustine, treanda, bendamustine side
effects, bendamustine rituximab, bendamustine
cost, bendamustine mechanism of action, treanda
cost, bendamustine hydrochloride, treanda side
effects,  
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