Regulation of blood glucose concentration

1

Regulation of Blood Glucose Concentration
R. C. Gupta Professor and Head Department of
Biochemistry National Institute of Medical
Sciences Jaipur, India
2
EMB-RCG
3
EMB-RCG
4
E M B - R C G
5
E M B - R C G
EMB-RCG
6
EMB-RCG
7
E M B - R C G
8
E M B - R C G
9
E M B - R C G
10
E M B - R C G
11
E M B - R C G
12
E M B - R C G
13
E M B - R C G
14
E M B - R C G
EMB-RCG
15
EMB-RCG
16
E M B - R C G
17
E M B - R C G
18
EMB-RCG
19
E M B - R C G
20
EMB-RCG
21
EMB-RCG
22
E M B - R C G
23
E M B - R C G
24
E M B - R C G
EMB-RCG
25
EMB-RCG
26
E M B - R C G
27
E M B - R C G
28
Some hormones raise blood glucose concentration
These are known as hyperglycaemic
(diabetogenic) hormones, and include
29
Some hormones decrease blood glucose concentration
These are known as hypoglycaemic
(antidiabetogenic) hormones

Insulin is the only
hypoglycaemic hormone
EMB-RCG
30
Growth hormone
E M B - R C G
31
Thyroid hormones
E M B - R C G
32
Glucocorticoids
E M B - R C G
33
Epinephrine
E M B - R C G
34
Glucagon
E M B - R C G
35
Insulin
E M B - R C G
Continued
36
EMB-RCG
37
E M B - R C G
38
E M B - R C G
39
The most common cause of hyper-glycaemia is
diabetes mellitus

• Diabetes mellitus may be caused by
• Deficient secretion of insulin or
• Decreased responsiveness to insulin

EMB-RCG
40
Hypoglycaemia is most frequently due to an
accidental overdose of antidiabetic drugs to a
diabetic patient
E M B - R C G
Less common causes are Addisons disease, severe
liver disease etc
41
EMB-RCG
42
Glucose Tolerance Test (GTT)
E M B - R C G
Continued
43
E M B - R C G
Continued
44
E M B - R C G
Continued
45
E M B - R C G
Continued
46
E M B - R C G
Continued
47
E M B - R C G
48
E M B - R C G
49
EMB-RCG
50
E M B - R C G
51
Glucose tolerance curve
52
E M B - R C G
53
(No Transcript)
54
After starting treatment of diabetes, blood
glucose measurements are required to monitor the
control of diabetes
However, post-glucose load measurement is not
required for monitoring purposes
Fasting blood glucose and 120-minute
post-prandial (post-meal) blood glucose are
measured for monitoring
EMB-RCG
55
E M B - R C G
EMB-RCG
56
Glycosylated haemoglobin
E M B - R C G
57
(No Transcript)
58
(No Transcript)
59
(No Transcript)
60
E M B - R C G
61
EMB-RCG
62
Alimentary glycosuria
Continued
63
(No Transcript)
64
Renal glycosuria
65
Thank you