ADC

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One-stop ADC Development Service
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INTRODUCTION

• Monoclonal antibody-based immunotherapies against
  cancer and other infectious diseases are highly
  advantageous comparing to conventional
  therapeutic approaches due to their high
  specificity and affinity towards well-defined
  targets.
• Antibody-drug conjugates (ADCs) inherit such
  superiorities and more remarkably, expand the
  therapeutic window of the conjugated drugs
  (payloads), which are usually highly toxic and
  diverse in their biochemical nature.

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• ADC mode of action. ADC molecules travel to the
  tumor site via systematic circulation, bind to
  tumor surface antigens, and enter the tumor cells
  via receptor mediated endocytosis
  (internalization). The payload is released in the
  cytosol or lysosome to eliminate the cancer cell
  by disrupting important cellular pathways
  (microtubule assembly, DNA transcription, mRNA
  processing).

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One-stop ADC Development Service
A flow chart summarizing the design of an ADC.
Correlations between different components in an
ADC intertwine, making the ADC design a
challenging yet interesting process.
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Antibody screening services
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Antibody screening services

• At the starting point of an ADC development
  project, Creative Biolabs offers antibody
  screening services including the consultation in
  antigen selection, antigen-specific antibody
  screening, internalizing antibody selection, as
  well as proof-of-concept feasibility validation
  using Anti-Ab ADCs.

• A suitable payload drug will be selected and
  coupled with a linker with desired releasing
  mechanism in DrugLnk to assemble the chemical
  warhead for an ADC, which is subsequently
  conjugated with the desired antibody using
  Antibody Design and Conjugation services. Certain
  modification or engineering of the selected
  antibody is also carried out in this service
  module.

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ADC in vitro Analysis
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ADC in vitro Analysis

• After ADC assembly, its biochemical
  characteristics (purity, stability,
  drug-to-antibody ratio) and in vitro efficacy is
  adequately analyzed in ADC in vitro Analysis
  while the ADCs pre-clinical pharmacological
  parameters will be assayed in ADC in vivo
  Analysis before clinical evaluation and
  applications.

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Antibody-based Probes
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Antibody-based Probes

• Lastly, Creative Biolabs is also an expert in the
  conjugation of various molecular probes to
  antibodies to form Antibody-based Probes and we
  offer this service to facilitate the requirements
  for the exponentially developing fields such as
  high-resolution imagery and fast, accurate
  diagnostics.

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• THANK YOU