Gilbert’s Syndrome

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Gilberts Syndrome
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Gilberts Syndrome

• Gilberts Syndrome (GS) is an inherent disease
  that is caused in the liver. It is a harmless
  genetic condition in which the liver enzyme (the
  protein molecule) becomes abnormal and cannot
  properly process bilirubin (waste due to worn
  out-red blood cells). It is generally due to a
  reduced number of chemicals in the liver.People
  with this disease experience elevated levels of
  bilirubin pigment, which may lead to yellowing of
  eyes and skin. Gilberts Syndrome is a genetic
  condition and is checked when you go through a
  blood test and that shows high bilirubin levels.

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Causes of Gilberts Syndrome

• The only cause of Gilberts Syndrome is an
  abnormal gene from either parent. This condition
  affects the liver and gives birth to an excessive
  amount of bilirubin. There is a presence of a
  gene in the liver that controls enzyme which
  breaks down the bilirubin. A person who is having
  an abnormal gene stores a large amount of
  bilirubin.The syndrome is caused by
• Deficiency of the uridine diphosphate
  glucuronosyltransferase enzyme or UGT.
• A change of the UDP-glucuronosyltransferase gene
  a faulty gene.

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Risks related with Gilberts Syndrome

• The main risk factors of this disease are
• Nausea
• Weakness
• Restlessness

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Prevention

• Gilberts Syndrome cannot be ignored as it is
  inherited, though, the following steps can help
  control the symptoms
• Balanced diet
• Drink plenty of water
• Avoid alcohol
• Manage stress
• Avoid junk food

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How is Gilberts Syndrome diagnosed?

• Gilberts Syndrome usually has no symptoms and
  can cause mild jaundice. Mild but prolonged
  jaundice can be a cause of worry as it increases
  the chances of serious liver disorders.The
  diagnostic plans for this disease include
• Study of the medical history of the patient and
  the patient's family
• Physical examination of the liver
• Blood count test
• Liver biopsy
• Urine test
• Liver test

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Symptoms of Gilberts Syndrome

• Symptoms of Gilberts Syndrome (GS) are not
  clearly identified in elevated levels of
  bilirubin. Mostly, people dont come to a
  realisation of having this disease, as the
  bilirubin levels mostly stay within normal limits
  and rarely raise that too slightly, to an
  extent that is tolerable.However, substances
  that are glucuronidated by the affected enzymes
  could cause symptoms such as
• Fatigue
• Difficulty in concentration
• Anxiety
• Loss of appetite
• Abdominal pain and itching without rashes

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How is Gilberts Syndrome treated?

• Gilberts Syndrome does not require major
  treatment, as it isn't a serious condition.
  Generally patients have normal life expectancy
  and healthy lifestyles without treatment.In
  specified cases, however, jaundice can be managed
  by a balanced diet and adequate intake of water.
  Patients can be benefited from Phenobarbital
  which is a medicine to lower bilirubin levels and
  it is taken when the symptoms of jaundice gets
  too disturbed.

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