Effects of Ibuprofen on Male Fertility - Elawoman

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Effects of Ibuprofen on Male Fertility - Elawoman
Men who take relatively high doses of ibuprofen
may be at increased risk for fertility problems,
early research suggests. The small study, which
was published yesterday (Jan. 8) in the journal
Proceedings of the National Academy of Sciences,
found that men who took 1,200 milligrams of
ibuprofen a day for six weeks developed a
hormonal condition that is linked with
reproductive problems. Ibuprofen Linked to Male
Infertility
However, because the study is small, more
research is needed to confirm the results. It's
also not clear whether the same hormonal effects
would be seen in men taking lower doses of
ibuprofen, or whether the effects are reversible,
particularly in men who take ibuprofen for long
periods, study co-author Bernard Jégou, director
of the National Institute for Research on
Environmental and Occupational Health in France,
told CNN. Still, over the short term, it's likely
that these effects are reversible, Jégou said.
Trying to Conceive 12 Tips for Men The study
involved 31 men (ages 18 to 35) who were randomly
assigned to take ibuprofen (two doses of 600 mg
each) or a placebo every day for six weeks. The
researchers found that, compared with the placebo
group, the men who took ibuprofen experienced a
23 percent increase in levels of luteinizing
hormone (LH) a hormone that's secreted by the
pituitary gland and stimulates the production of
testosterone after two weeks.
Higher-than-normal levels of luteinizing hormone
can indicate a problem with the testes,
according to the National Institutes of Health.
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However, despite the change in LH levels, the
men's testosterone levels didn't change. This
indicates that they had developed a condition
called "compensated hypogonadism," which happens
when testosterone production is reduced, but the
body is able to compensate by increasing LH
levels, the researchers said. Compensated
hypogonadism is typically found in older men, and
it is linked with impaired fertility, according
to the study. Separate experiments in the study
using human testicular tissue in a lab dish also
suggested that ibuprofen could affect
testosterone production. It's important to note
that the study did not look at sperm production
or other more direct indicators of the men's
fertility, so further studies would be needed to
examine this, the researchers said. People who
take over-the-counter ibuprofen tablets for pain
or fever should not take more than 1,200 mg per
day unless directed by a doctor, according to
Medscape. For example, the makers of Advil,
which contains ibuprofen, recommend that people
do not take more than 1,200 mg (or six 200-mg
pills) in a 24-hour period. Taking the common
painkiller ibuprofen has been linked in a small
study with a condition affecting male fertility
problems. Male fertility is dropping around the
world and the researchers wanted to see if
ibuprofen might be contributing to
this. Ibuprofen and Male Infertility
Ibuprofen is a non-steroidal anti-inflammatory
drug sold without a prescription for short-term
treatment of pain, inflammation from injuries,
and fever. Health professionals may recommend
longer-term use. It is known to increase the
risk of heart attacks and stroke if taken
regularly in high doses for a long time. It has
already been linked with fertility problems in
women taking the drug. Common brands of
ibuprofen include Advil and Motrin. The Danish
and French study looked at 31 athletic men
between the ages of 18 and 35. Half the group
took 600mg of ibuprofen twice a day the maximum
recommended dose in the U.S. is 800mg up to four
times a day -- for 2 weeks. The other half
took a dummy (placebo)
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tablet. Samples were taken before and after the
trial for comparison. Effects of Ibuprofen on
Male Fertility
Those who took the ibuprofen were more likely to
have indications of testicular problems --
including a condition called compensated
hypogonadism that affects reproductive health --
meaning men are less likely to be able to father
a child. This is more common in older men than
younger ones. Ibuprofen appears to affect the
pituitary gland that's involved in production of
the male hormone testosterone, as well as other
processes linked to sperm production. Infertility
affects approximately 1 out of every 6 couples.
An infertility diagnosis is given to a couple
who are unable to conceive over the course of one
year. When the problem lies with the male
partner it is referred to as male infertility.
Male infertility factors contribute to
approximately 30 of all infertility cases, and
male infertility alone accounts for approximately
one-fifth of all infertility cases. What causes
male infertility? There are four main causes of
infertility in males

A hypothalamic or pituitary disorder (1-2)
Gonad disorder (30-40) Sperm transport disorder
(10-20) Unknown causes (40-50)
Much research remains to be performed on the
topic of male infertility, as many cases still
receive an unknown cause diagnosis. Male
infertility usually occurs because of sperm that
are abnormal, because of inadequate numbers of
sperm, or problems with ejaculation. Male
Infertility Issues
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Sperm can be considered abnormal for two possible
reasons unusually short life span of the sperm
and/or low mobility. Sperm abnormalities may be
caused by one or more of the following

Inflammation of the testicles Swollen veins in
the scrotum Abnormally developed testicles
Reasons for a low sperm count or lack of sperm
include one or more of the following

A pre-existing genetic condition Use of alcohol,
tobacco or other drugs Severe mumps infection
after puberty Hernia repairs Hormone
disorder Exposure to poisonous chemicals
Exposure to radiation Blockage caused from a
previous infection Wearing restrictive or tight
underwear Injury to the groin area
Male Infertility can also occur when there are
problems with ejaculation.
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Menstrual Cramps are painful sensations that
affect many women before and during a menstrual
period. The pain, also known as dysmenorrhea or
period pains, ranges from dull and annoying to
severe and extreme. Menstrual cramps tend to
begin after ovulation when an egg is released
from the ovaries and travels down the fallopian
tube. Pain occurs in the lower abdomen and lower
back. It usually begins 1 to 2 days before
menstruation and lasts from 2 to 4 days.

• Pain that is only associated with the process
  of menstruation is known as primary
  dysmenorrhea. If the cramping pain is due to an
  identifiable medical problem such as
  endometriosis, uterine fibroids, or pelvic
  inflammatory disease, it is called secondary
  dysmenorrhea.
• If the woman is a good candidate, a physician may
  prescribe hormonal birth control pills to
  prevent ovulation and reduce the severity of
  menstrual cramps. These work by thinning the
  lining of the uterus, where the prostaglandins
  form. This reduces cramping and bleeding.
• In some cases, birth control pills can be used
  continuously, without the 4 to 7-day break each
  month that is normally adhered to. There will be
  no bleeding at all, in this case. Other types of
  birth control, including some types of hormonal
  IUD, vaginal rings, patches, and injections can
  all help decrease cramping.If the cramps are due
  to an underlying medical condition, such as
  endometriosis or fibroids, surgery may be needed
  to remove the abnormal tissue.
• Do not sleep with a heated pad as it could cause
  burns. before purchasing a TENS unit, compare
  brands and product reviews.
• Home remedies
• Researchers at Imperial College London found that
  ingredients in chamomile tea may help relieve
  menstrual pains by relaxing the uterus.
• Compare different brands online. In another
  study, Chinese herbal medicines were found to
  help reduce menstrual cramps, but the authors
  called for more research.

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• Some dietary options, including herbs and vitamin
  supplements, may help. Some examples are
  lavender, fennel, and pycnogenol. These have very
  little risk.
• One study suggests that ginger powder may help if
  taken during the first 3 to 4 days of the
  menstrual cycle. Ginger poweder is available to
  purchase online.
• If you choose to use any herbal or supplement
  approaches, be cautious. The United States Food
  and Drug Administration (FDA) does not regulate
  herbs and supplements for quality or purity.
• Getting enough rest and sleep and regular
  exercise may help.

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