Benefits of Carboplatin Injections

1
What is Carboplatin?
Is a chemotherapy drug used against some forms
of cancer (mainly ovarian carcinoma, lung, head
and neck cancers as well as endometrial,
esophageal, bladder, breast and cervical central
nervous system or germ cell tumors osteogenic
sarcoma, and as preparation for a stem cell or
bone marrow transplant).
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2
Indications and Usage
The recommended dosage for previously untreated
adults (normal renal function) is 400mg/m² as a
single intravenous infusion over 15-60 minutes.
Therapy should not be repeated again until four
weeks have elapsed. In patients with risk factors
such as previous myelosuppressive therapy or in
the aged, the initial dosage may need to be
reduced to 20-25. Determination of the
haematological nadir by weekly blood counts is
recommended for adjusting future doses and
scheduling of carboplatin.
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3
Patients with Impaired Kidney Function
Patients with creatinine clearance values below
60 mL/min are at increased risk of severe bone
marrow suppression. In renally-impaired patients
who received single-agent carboplatin therapy,
the incidence of severeleukopenia, neutropenia,
or thrombocytopenia has been about 25 when the
dosage modifications in the table below have been
used.  
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4
Side Effects

1. Relative to cisplatin, the greatest benefit of
   carboplatin is its reduced side effects,
   particularly the elimination of nephrotoxic
2. Nauseaand vomiting are less severe and more
   easily controlled.
3. The main drawback of carboplatin is its
   myelosuppressive effect.
4. This causes the bloodcell and platelet output of
   bone marrow in the body to decrease quite
   dramatically, sometimes as low as 10 of its
   usual production levels.
5. This decrease in white blood cells(neutropenia)
   can cause complications, and is sometimes treated
   with drugs like filgrastim.

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5
Mechanism of Action
Carboplatin is a cisplatin derivative and shares t
he same mechanism of action. Highly reactive
latinum complexes are formed intracellularly. Thes
e complexes inhibit DNA synthesis through covalent
 binding of DNA molecules to form intrastrand and 
interstrand DNA crosslinks. Carboplatin is conside
red to be cell cycle phasenonspecific, but recent 
studies have shown complex and variable effects on
 the cell cycle.  
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