Transforming growth factor beta

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Transforming growth factor beta
by Creative BioMart
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The transforming growth facor beta (TGF-ß)
superfamily is a large family of growth factors
named after the first member TGF-ß1. Members of
TGF-ß superfamily are similar in structure. TGF-ß
superfamily distributes in invertebrates as well
as vertebrates species.
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They play role in dorso-ventral patterning,
mesoderm induction and patterning, and also in
limb bud formation, bone and cartilage formation,
neuron differentiation. So TGF-ß superfamily is
important in development of a variety of
different tissues and organs.
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The transforming growth factor-ß (TGF-ß)
superfamily is a family of proteins that is
involved in regulating and mediating processes at
the cellular level, including cell proliferation,
differentiation, motility, adhesion and
apoptosis, as well as processes at the tissue and
organism level, including development, wound
healing, fibrosis and angiogenesis. The TGF-ß
superfamily consists of ligands and receptors
that all signal, at least in part, through well
characterized downstream mediators termed the
Smads.
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TGF beta related literatures 1. Herpin A, Lelong
C, Favrel P. Transforming growth factor-ß-related
proteins an ancestral and widespread superfamily
of cytokines in metazoansJ. Developmental
Comparative Immunology, 2004, 28(5) 461-485. 2.
Massagué J. TGF-ß signal transductionJ. Annual
review of biochemistry, 1998, 67(1) 753-791. 3.
Gordon K J, Blobe G C. Role of transforming
growth factor-ß superfamily signaling pathways in
human diseaseJ. Biochimica et Biophysica Acta
(BBA)-Molecular Basis of Disease, 2008, 1782(4)
197-228. 4. Dong M, How T, Kirkbride K C, et al.
The type III TGF-ß receptor suppresses breast
cancer progressionJ. Journal of Clinical
Investigation, 2007, 117(1) 206.
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