What is TNF

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What is TNF?
--Creative BioMart
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What is Tumor necrosis factor (TNF)
superfamily? Tumor necrosis factors (TNF)
superfamily composes of a group of cytokines and
their receptors which can reduce cell death
(apoptosis). This superfamily is composed of 19
ligands and 29 receptors in humans. TNFa and
Lymphotoxin-alpha (LTa) is first identified
members of the family.
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TNF has also been called cachectin and
differentiating factor (DIF) due to its role in
chronic wasting disease and its ability to
promote differentiation in some hematopoetic
cells. Since its discovery, more than 20
homologues of TNF have been identified with
15-20 identity between family members, all of
which have affects upon the immune system. Thus,
there is a TNF superfamily composed of related
proteins.
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TNF promotes the apoptosis, programmed cell
death, or necrosis of certain cancer cell lines
in pM concentrations. Apoptosis and necrosis is
induced by TNF activation of pro-death pathways.
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TNF is involved or implicated in many
immunological disorders, as well as various
disease states. TNF is a mediator of inflammation
observed in patients with rheumatoid arthritis
and inhibition of TNF with neutralizing
antibodies can stop progression of the disease.
TNF is involved in the inflammation observed
during the onset of multiple sclerosis and type 1
diabetes.
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