Transporter Screening

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Transporter Screening

-Profacgen
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Transporters are a group of specialized membrane
proteins that power the translocation of numerous
substances, including essential nutrients, ions,
neurotransmitters, cellular waste and
environmental toxins, across the cellular
membrane. Many transporters have emerged as
therapeutic targets for diseases such as
depression, schizophrenia, cancer, and diabetes.
Therefore, transporter screening for
therapeutically effective and safe compounds has
become very important in the discovery and
development of transporter-targeted drugs.
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Second Page
Profacgen provides specialized transporter panels
and customized transporter screening services
enabling you to identify novel transporter-targete
d compounds. Our transporter panels include FDA
transporter screening panel, monoamine
transporter models and many other cell models. We
employ robust transporter uptake and inhibition
assays to perform quick and cost-effective
screening of new molecular entities (NMEs) for
their interactions with transporters, and offer
you results with good signal-to-background ratio
and Z scores.
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Assays Electrophysiology Radioactive flux
detection Fluorescence detection
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Features Cell based assays providing
functional characterization of compound activity
Coverage of key transporters Availability of
various panels Short turn-around time
Customized screening project design
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Contact Profacgen Email contact_at_creative-biom
art.com website https//www.profacgen.com/transp
orter-screening-service.htm