Zofran Side Effects

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Zofran Side Effects
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Zofran In Pregnancy May Be Responsible For
Congenital Malformations
Once again, the multinational pharmaceutical
GlaxoSmithKline (GKS) is making headlines for
endangering patients by marketing its drugs
Zofranfor unapproved purposes.  As per a register
based nationwide cohort study, Ondansetron
medication in early pregnancy may be responsible
for Congenital Malformations. The study
investigates teratogenic risks with Zofran. A
teratogen is any exposure that can cause harm
to an unborn or breastfeeding baby. Teratogens can
be alcohol, prescription/non-prescription
medications, illegal drugs, vaccines, illnesses,
environmental exposures, occupational exposures,
or maternal autoimmune disorders. A Danish study
done by Danish Researchers in 2013 engaging
600,000 births found that there was no serious
risk of Zofran birth defects. Nevertheless, six
months later, another study based on 900,000
births from the same registry found a 30
increased risk of Zofran birth defects overall,
and a doubled risk of heart defects.
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Zofran Side Effects
Zofran contains ondansetron hydrochloride and is
a generic medication manufactured by
Glaxosmithkline(GSK). Zofran is mainly prescribed
to treat nausea and vomiting in patients who are
receiving chemotherapy or radiation therapy in
cancer treatment or after the surgery. It affects
the serotonin levels in the brain and was
approved in the year 1991 to treat nausea and
vomiting in cancer related cases. Since then
doctors continue to prescribe it to treat nausea
and vomiting for pregnancy (NVP). Zofran has
been used as an off-label treatment for
pregnancy related to nausea and vomiting. 
Doctors are allowed to use drugs as off-label
treatment if the hazard overshadows the benefits
but drug companies cannot encourage or market
medications for a use of this kind.
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