The 7th International Conference on Ubiquitination and Ubiquitin Protein

1
The 7th International Conference on
Ubiquitination and Ubiquitin Protein

• On 10th to 13th May, 2014, the 7th international
  conference on ubiquitination and ubiquitin
  protein was held in Shanghai Jiaotong University.
  This conference was jointly organized by the
  university of Texas MD Anderson Cancer Center and
  Shanghai Jiaotong University. Many famous
  scientists came together to discuss this
  significant emerging field on the clinical
  application.

2

• This conference was mainly focusing on estimating
  the most effective target and the new drugs of
  targeting molecules. Attendees would have a deep
  learn about the research progress of this
  technology. These progress will be connected with
  the treatment of tumors and the most advanced
  treatment. Whats more, it will contribute a lot
  to researches of cancer treatment and other
  diseases.

3

• Ubiquitination and uibiquitin protein are playing
  an important role in protein post-translational
  modification. They are very significant
  substances in the cell regulation, cell
  differentiation, cell signaling pathway.
  According to the research of anemia,
  ubiquitination and uibiquitination protein have a
  close relationship with this disease. There was a
  paper published on CELL magazine, which was
  mainly focusing on the anemia. This article
  showed that hypoxia-inducible factor (1a) will
  occur SUMO modification under the hypoxia
  condition. This will promote the combination of
  HIF 1a and Hippel-Lindau. And then the
  ubiquitination degradation will occur. So we can
  conclude that the formation of red blood cells is
  regulated by the ubiquitination and SUMO, which
  will pave a new way for the research of clinical
  treatment.

4

• Ubiquitination is a low component protein. It
  means that ubiquitination moleculars modify the
  target proteins with the help of enzymes. Some
  special enzymes will classify the proteins in the
  body to pick up the target proteins. It is very
  important in the localization, metabolism,
  function, regulation and degradation of proteins.
  The process of ubiquitination is a little
  complicated. The main three enzymes are ubiquitin
  activating enzyme, ubiquitin conjugating enzyme
  and ubiquitin ligase. The reaction of the three
  enzymes are the main process of ubiquitination.

5

• We introduce applications of ubiquitination and
  ubiquitination proteins in all kinds of diseases
  and researches. We can conclude that the function
  of ubiquitination is attracting more and more
  attention of scientists and doctors. The future
  of this field is bright and we all believe that
  the ubiquitination technology will play a very
  important role in our future biotechnology.