Information About Acetylation Modification for Students

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Information About Acetylation Modification for
Students

• Summary
• Regulating certain metabolic enzymes in the human
  body and controling diabetes are the main
  function of protein acetylation. So it is very
  important for scientists to do experiment in this
  field. Here I will introduce something about the
  Acetylation Modification for you.

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• Body
• What is the protein acetylation? It is the
  process that Acetyl is added to protein lysine
  residues and then it can be used by cells to
  control gene expression, protein activity or
  physiological processes.
• Histone acetylation occurs in specific lysine
  residues in the N-terminal basic amino acid
  concentration area. And then acetyl coenzyme A
  will be transferred to the lysine sNH3 and a
  positive charge will be neutralized.
• Now I will mainly introduce the acetylation
  modification, including its function and meaning
  to you.

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• The function of acetylation modification
• As we mentioned above, the main function of
  acetylation modification is to regulate certain
  metabolic enzymes in the human body and control
  diabetes. That means that it is a great
  achievement for diabetes treatment by regulating
  a metabolic enzymes--PEPCK1 to control glucose
  concentration effictively. This achievement has
  been published on the international cell
  magazine--Molecular Cell. It is reported that
  there is a process called as Gluconeogenesis,
  which means that amino acid and some other
  non-glucose nutrients in human body are
  transferred into glucose. Generally speaking, our
  body will transfer glucose automatically. And the
  PEPCK1 is the key enzyme for controling the
  process of Gluconeogenesis. The function of
  PEPCK1 is to change the other energy into glucose
  through the gluconeogenesis. If the activity of
  PEPCK1 is nuch higher than normal level, the
  content of glucose in blood will be increased and
  then the diabbetes is coming. So ir is a very
  important method to control diabetes by
  regulating PEPCK1 seriously.

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• The meaning of researching acetylation
  modification
• The main function of acetylation modification is
  mainly focusing on affecting the structure of
  chromosome and activatiing the nuclear
  transcription factor. Whats more, researchers
  from FuDan University had found out other meaning
  of the acetylation modification
• Protein acetylation modification is not minority,
  it is most likely to affect a wide modification
  of every aspects under the physiological state of
  cells. It can be regarded as a mile stone in this
  field.
• It is the first time to find that the acetylation
  modification exsits in the metabolic enzymes and
  it also regulate the metabolomic system and the
  activity of metabolic enzyme. This can be an
  important basis for the use of all kinds of
  medicine and vitamins.
• The protein acetylation has high specificity
  features.
• As we all know that 80 diseases of human have
  connection with metabolism, so this research
  offer the new idea for prepare medicine for
  regulating metabolism.

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• There are other information about the protein
  acetylation. It will become the main field for
  scientists to do experiment on diabetes.