Cell launched Four Cancer Immunotherapy Featured Reviews

1
Cell launched Four Cancer Immunotherapy Featured
Reviews By
Creative BioMart
2
Although it has been years since the idea of
using immune system to fight against cancer come
into being, only until recent years do scientists
find some successful treatment strategies. By
manipulating the immune checkpoints and T cell
activation to exert anti-tumor activity,
immunotherapy has been applied to a wider range
of malignancies now, while it only showed
therapeutic potential in several types of cancers
in the very beginning.
3

Recently the Cell magazine, titled as "Harnessing
Immunotherapy against Cancer", launched a series
of selection reviews, making a comprehensive
description of the origins of some of the cancer
immunotherapy, the molecular basis of the immune
response, some implementations cancer
immunotherapy technology, and how they contribute
to some extraordinary achievements of the cancer
treatments.

4
Immune Checkpoint Targeting in Cancer Therapy
Toward Combination Strategies with Curative
Potential

• In this review, James P. Allison and Padmanee
  Sharma, discusses the past, present and future
  direction of immunotherapy, and proposed that
  immune system may play in tumorigenesis an
  extremely important role. They also describes
  that some recent molecular studies found some
  factors that play an important role in the immune
  checkpoint blockade and T cell activation, which
  may become a new therapeutic target for therapies
  design.

5
Immune Checkpoint Blockade A Common Denominator
Approach to Cancer Therapy

• In this article, Suzanne Topalian, Charles Drake
  and Drew Pardoll have made a comprehensive
  overview of the potential molecular signaling
  pathways of immune checkpoints. And the discovery
  of how these mechanisms contribute to some new
  treatments. This knowledge may lead people get
  major victory in the anti-cancer war.

6
Engineering CAR-T cells Design concepts

• Manipulation of T cell activation plays an
  important role in cancer immunotherapy. Some
  development of molecular biology techniques makes
  it possible to manipulate the signal pathway of T
  cells to help promote this strategy, and now
  researchers are moving to change the
  antigen-specific of T cells. In this review,
  Shivani Srivastava and Stanley Riddell
  investigate tumor-targeting chimeric receptors
  molecular biology, these receptors can enhance T
  cell adoptive immunotherapy effect, and they have
  the potential to foster a specific and safe
  anti-tumor response.

7
Synthetic biology in cell-based cancer
immunotherapy

• Synthetic biology methods, allowing researchers
  with unprecedented sensitivity and specificity to
  manipulate cell signaling pathways, has been used
  to tackle with a wide range of biological
  problems. Deboki Chakravarti and Wilson Wongemail
  described some of methods like through the
  development of synthetic receptors, switches and
  loops to control T cell activity, we can use them
  to improve the efficacy of cancer immunotherapy.

8
Thanks for watching

• Text source http//www.creativebiomart.net/blog/c
  ell-launched-four-featured-cancer-immunotherapy-re
  views/