Flexible and Dynamic GPCRs

1
Flexible and Dynamic GPCRs

• Editor Elaine
• Company Creative Biolabs
• Website http//www.creative-biolabs.com/
• Tel [phone]
• Email info_at_creative-biolabs.com

2

• Will you feel a sense of pride and accomplishment
  when you get the Nobel Prize in chemistry? Will
  you feel different when you are as an object of
  study to research biochemical signals like
  G-protein coupled receptors? Can you imagine
  that?

3

• GPCRs belong to a very large family of proteins,
  which mainly involves in the signal transduction,
  whose topological conformation is the receptors
  of seven transmembrane. When the ligands outside
  membrane are connected with receptors, the
  interior of the receptors will mutually bind with
  each other and then activate the G-protein. While
  as for G-protein, there are two approaches to
  transmit extracellular information. The first
  approach is to open the transmembrane ion
  channels so that the ions can enter from outside.
  The second is to activate a second messenger, sch
  as cAMp and DAG. In fact, Calcium ions are
  guenerally considered as the third messengers.

4

• Generally speaking, GPCRs are structurally
  flexible and dynamic because they can apply
  different structures, namely the conformation, to
  diverse factors. It is believed that a
  conformational equilibrium exists in GPCRs
  molecule between active and inactive biophysical
  states so it is necessary to pay more attention
  to the binding of ligands to GPCRs for they might
  change the equilibrium toward the active
  receptors. In terms of the current social
  reality, molecular drug targets have become
  extensively important in the application of
  modern new drugs, and drug targets might be more
  effective with the further research of GPCRs.

5

• Moreover, an increasing number of laboratories
  focus on the structures and mechanisms of GPCRs.
  Why? It is because of the fact that analyzing the
  structures of GPCRs is critical to help
  understand the mechanisms. And its significant
  in designing more effective drugs. Its no
  exaggeration to say that it will bring a new
  vitality for pharmaceutical industry.

6

• Creative Biolabs has been known for its
  breakthrough GPCRs production technology. It has
  completed a professional platform to offer an
  integrated service in producing GPCRs.
  Additionally, many scientists from Creative
  Biolabs can analyze the utility of customized
  GPCRs as well. Given the fact that many drugs are
  always directed at a certain target and GPCRs are
  dynamic and flexible, thus the research of GPCRs
  can be significant in the understand of drug
  mechanisms and promote the advance of modern new
  drugs to a large degree.

7
About Creative Biolabs Creative Biolabs is a
leading custom service provider that has
extensive experience in GPCRs. Scientists in
Creative Biolabs can evaluate and analyze the
utility of customized GPCRs for certain
pharmaceutical research and drug
discovery. Links Creative Biolabs
http//www.creative-biolabs.com/ GPCRs
http//www.creative-biolabs.com/Custom-GPCR-Produc
tion-Service.html Source (Read full
text) http//www.scienceplease.com/events/flexibl
e-and-dynamic-gpcrs