Journal of diabetes research

1
International Journal of Diabetology
Vascular Disease Research IJDVR
http//scidoc.org/IJDVR.php
ISSN-2328-353X
2

• Article name
• Harmonizing Eating and Exercise Circadian
  Rhythms for Optimal Glucose-Insulin and Vascular
  Physiology
• This article establishes a global but individual
  public program based on rhythmic circadian eating
  and exercise extent and rate to harmonize
  intermediary metabolism. This will help optimize
  glucose assimilation and insulin dynamics towards
  healthier heart and vascular functions. Any and
  every circadian meal must have its matching
  physical activity to optimize substrate oxidation
  and waste management.
• Link http//scidoc.org/IJDVR-2328-353X-03-301.ph
  p
• Article Name
• An Increase of Maximal Intima-Media
  Thickness in Bilateral Carotid Arteries Strongly
  Suggests the Existence of Coronary Stenosis in
  Japanese Type 2 Diabetic Patients
• An association of an increase of
  maximal intima-media thickness (IMT) of carotid
  artery to coronary artery stenosis was evaluated
  in Japanese type 2 diabetic (T2DM) out-patients
  without any typical cardiac symptoms or history.
  Maximal IMT from common carotid artery to
  internal carotid artery was measured by
  ultrasonography in T2DM outpatients without any
  typical symptoms or history of coronary artery
  disease (CAD). The patients with a significant
  increase of maximal IMT over 1.5 mm were
  consulted to cardiologists, and the existence of
  coronary artery stenosis was evaluated by
  multiple detector-row computed tomography (MDCT).
  The patients with coronary artery stenosis
  suspected by MDCT were additionally evaluated the
  existence of CAD by coronary angiography. From
  April 2013 to December 2014, we found 17 patients
  with an increase of maximal IMT in bilateral
  carotid arteries and 9 patients with an increase
  of maximal IMT in unilateral carotid artery in
  T2DM outpatients. The patients with a significant
  increase of maximal IMT in bilateral carotid
  arteries had higher incidence of coronary artery
  stenosis by coronary angiography (76.5 )
  thanthose in unilateral carotid artery (11.1).
  The 47.1 of the patients with an increase of
  maximal IMT in bilateral carotid arterieswas
  judged to needpercutaneous coronary intervention
  therapy. In conclusion, a significant increase of
  maximal IMT in bilateral carotid artery strongly
  suggests the existence of coronary artery
  stenosis in Japanese T2DM patients. Screening of
  maximal IMT in bilateral carotid arteries should
  be beneficial for the detection of silentischemia
  in coronary artery.
• Link http//scidoc.org/IJDVR-2328-353X-03-201.ph
  p

3

• Article Name
• Pathophysiologic Aspects of Hypertension
• Hypertension is defined as a sustained
  increase in blood pressure. Historically, the
  level of blood pressure designating hypertension
  has been a systolic blood pressure of 140 mm Hg
  or more and/or a diastolic blood pressure of 90
  mm Hg or more. However, the risk imparted with
  increasing blood pressure is continuous, such
  that the level of blood pressure must be
  considered within the context of the overall
  cardiovascular risk profile. Clearly,
  antihypertensive treatment helps to prevent both
  cardiovascular and cerebrovascular events, the
  dreaded complications of increased blood
  pressure. Nevertheless, hypertension remains
  unrecognized or inadequately treated in the great
  majority of patients. This work aims to review
  the essential key element for the understanding
  of hypertension's pathophysiology.
• Link http//scidoc.org/IJDVR-2328-353X-03-101.ph
  p
• Article Name
• Effect of Aqueous Extract from Erythrea
  Centaurium in Merione Shawi
• The aqueous extract of E. centaurium,
  administered to merione at 200 mg/kg for 6 months
  produced a significant reduction in glycemia,
  insulinemia, fructosamine and glycosylated
  haemoglobin. It also exhibited an important
  decrease of lipidic parameters such as
  cholesterol, LDL-cholesterol, triglycerids. The
  results showed no significant diminution of the
  weight.
• Link http//scidoc.org/IJDVR-2328-353X-02-701.ph
  p
• Article Name
• A Short Review of Some Medicinal Plants
  And Phytocompounds With Hypotensive And
  Hypoglycemic Activities
• This paper aims to review some medicinal
  plants and compounds of botanical origin which
  are capable to lower plasma glucose levels and
  blood pressure. Hypoglycemic natural products
  comprise flavonoids, xanthones, triterpenoids,
  alkaloids, glycosides, alkyldisulfides.
  aminobutyric acid derivatives, guanidine,
  polysaccharides and peptides. Hypotensive
  compounds include flavonoids, diterpenes,
  alkaloids, glycosides, polysaccharides and
  proteins.
• Link http//scidoc.org/IJDVR-2328-353X-02-501.ph
  p

4

• Article Name
• On Research to Optimize Eating Timing
  Simple Solutions for Complex Problems
• Recent accomplishments in animal and
  human physiology have contributed to urgency for
  creating innovative research on timing of
  nutrient intake . These findings suggest that
  feeding and eating times during the 24-h period
  matter in how efficiently nutrients are utilized
  and partitioned into different tissues notable
  splanchnic and peripheral tissues. Shifting
  eating time from morning to evening in once-daily
  fed dairy and beef cattle has increased nutrient
  efficiency and milk fat and energy production.
  Such effects have mainly been resulted from
  altered circadian and postprandial rhythms of
  nutrient intake and energy-yielding metabolites
  and hormones .On the other hand, evidence exists
  that human glucose intolerance and insulin
  resistance develop as day ends and night begins.
  Thus, despite the discovery that evening feeding
  may improve production and economics in
  food-producing animals, due to inter-species
  differences in evolutionary intermediary
  metabolism and eating behaviour, it could
  seriously impair the human physiology and health.
• Link http//scidoc.org/IJDVR-2328-353X-02-004e.p
  hp
• Article Name
• Treatment of Hypercholesterolemia in
  Patients with Diabetes Mellitus
• Numerous studies have shown that
  statins reduce cardiovascular events including
  stroke and mortality in diabetics. The American
  Diabetes Association 2013 guidelines recommend
  that diabetics at high risk for cardiovascular
  events should have their serum low-density
  lipoprotein (LDL) cholesterol reduced to lt70
  mg/dL with statins. Lower-risk diabetics should
  have their serum LDL cholesterol reduced to lt 100
  mg/dL. The 2013 American College of
  Cardiology/American Heart Association lipid
  guidelines recommend giving high-dose statins to
  adult diabetics aged 75 years with
  atherosclerotic vascular disease (ASCVD) unless
  contraindicated with a class I indication and
  moderate-dose or high-dose statins to diabetics
  with ASCVD 75 years with a class IIa indication.
  Diabetics 21 years with a serum LDL cholesterol
  of 190 mg/dL should be treated with high-dose
  statins with a class I indication. For primary
  prevention in diabetics aged 40 to 75 years and
  serum LDL cholesterol between 70 to 189 mg/dL,
  moderate-dose statins should be given with a
  class I indication. For primary prevention in
  diabetics aged 40 to 75 years, a serum LDL
  cholesterol between 70 to 189 mg/dL , and a
  10-year risk of ASCVD of 7.5 calculated from
  the Pooled Heart Equation, high-dose statins
  should be given with a class IIa indication. For
  primary prevention in diabetics aged 21 to 39
  years or older than 75 years and a serum LDL
  cholesterol between 70 to 189 mg/dL,
  moderate-dose statins or high-dose statins should
  be given with a class IIa indication. There is no
  additional ASCVD reduction from adding nonstatin
  therapy to further lower non-high-density
  lipoprotein (HDL) cholesterol once an LDL
  cholesterol goal has been reached. Clinical
  trials have found no lowering of cardiovascular
  events or mortality in diabetics treated with
  statins by addition of nicotinic acid, fibric
  acid derivatives, ezetemibe, or drugs that raise
  serum HDL cholesterol.
• Link http//scidoc.org/IJDVR-2328-353X-02-301.ph
  p

5

• Article Name
• Hyperglycemic Challenge and Distribution
  of Adipose Tissue in Obese Baboons
• Background Blood glucose levels
  regulate the rate of insulin secretion, which is
  the bodys mechanism for preventing excessive
  elevation in blood glucose. Impaired glucose
  metabolism and insulin resistance have been
  linked to excess body fat composition. Here, we
  quantify abdominal muscle and abdominal adipose
  tissue compartments in a large nonhuman primate,
  the baboon, and investigate their relationship
  with serum glucose response to a hyperglycemic
  challenge.Methods Five female baboons were
  fasted for 16 hours prior to 90 minute body
  imaging experiment that consisted of a 20-min
  baseline, followed by a bolus infusion of glucose
  (500mg/kg). The blood glucose was sampled at
  regular intervals. The total volumes of the
  muscle, visceral and subcutaneous adipose tissue
  were measured.Results and discussion We found
  that adipose tissue composition predicted
  fluctuations in glucose responses to a
  hyperglycemic challenge of a non-human primate.
  Animals with higher visceral adiposity showed
  significantly reduced glucose elimination. The
  glucose responses were positively correlated with
  body weight, visceral and muscle fat (plt0.005).
  Polynomial regression analysis showed that body
  weight, visceral and muscle were significant
  predictors of serum glucose responses
  (plt0.001).Conclusions These results reveal the
  similarity between humans and baboons with
  respect to glucose metabolism and strengthen the
  utility of baboon for biomedical research.
• Link http//scidoc.org/IJDVR-2328-353X-02-101.php