Research at the Thames Cancer Registry

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Research at the Thames Cancer Registry Henrik
Møller Director, Thames Cancer Registry.
Professor of Cancer Epidemiology, GKT School
of Medicine, Kings College London and London
School of Hygiene Tropical Medicine.
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Areas of research

• Health services research studies looking at the
  time around diagnosis
• Descriptive epidemiology patterns of variation
  in incidence, mortality and survival
• Research in aetiology studies looking at events
  prior to the time of diagnosis
• Outcomes research studies looking at events
  subsequent to the time of diagnosis

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• Health services research studies looking at the
  time around diagnosis

• Breast cancer audit
• Colorectal cancer audit
• Haematology database (Karen Phekoo)
• Lung cancer study (Ruth Jack)
• Completeness of cancer registration
• Studies on waiting times and delays

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• Descriptive epidemiology patterns of variation
  in incidence, mortality and survival

• Exploration of the TCR database
• Analysis of incidence trends in Thames
• Age-period-cohort analysis of cancer incidence
• Models of prevalence
• Gastric and oesophageal cancer
• Prostate cancer

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Age-standardised incidence rate (European
standard population) of prostate cancer in
southeast England, 1990-1999 by stage at
diagnosis
Localised
Non-localised
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Age-standardised rate of total excision of
prostate and capsule of prostate (OPCS4 M61.1) in
southeast England, 1990-1998. Hospital Episode
Statistics, DoH
45-69y
70y
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Age-standardised rate of transurethral resections
of the prostate (TURP) in southeast England,
1990-1998. Hospital Episode Statistics, DoH
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Mesothelioma 1996-2000Age-standardised incidence
rates - males
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• Research in aetiology studies looking at events
  prior to the time of diagnosis

• Tamoxifen study (Michael Jones)
• Radiotherapy and cardiovascular disease (Sarah
  Darby)
• Mammography screening
• Studies on rare cancers
• Hormone replacement therapy (Emily Banks)
• Analysis of multiple primaries

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• Outcomes research studies looking at events
  subsequent to the time of diagnosis

• Cancer survival in relation to stage and
  deprivation
• EUROCARE
• Cancer survival in Europe and North America
  CONCORD study (Michel Coleman)
• Prostate cancer in UK and USA (Jack Cuzick)
• Mammography screening and breast cancer mortality
• Cancer survival analysis period analysis and
  cure models

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Design options for relative survival analysis

• Cohort analysis
• Period analysis
• (cross-sectionally)

90
86
2000
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86
2000
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Period
Cohort
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Period
Cohort
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TCR Research Department

• Jan Bell, senior researcher
• Helen Evans, researcher
• Angela Newnham, senior lecturer
• Venkata Putcha, senior researcher
• David Robinson, statistician
• Ashu Sehgal, research assistant

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www.thames-cancer-reg.org.uk