Asian Pacific Organization for Cancer Prevention APOCP

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Asian Pacific Organization for Cancer
Prevention (APOCP)
Cancer Epidemiology and Prevention
Education Screening Toxicological Pathology
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ASIAN PACIFIC JOURNAL
of CANCER
PREVENTION The Official Publication of the
Asian Pacific Organization for Cancer
Prevention An Official Journal of the
International Association of Cancer Registries
APOCP Groups Australasia Central
Asia China Japan Korea South Asia South-East
Asia Western Asia
Vol 5 2004
Education Epidemiology Screening
and Intervention Toxicological Pathology
http//www.apocp.org
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ASIAN PACIFIC ORGANIZATION for CANCER
PREVENTION
Aims and Scope      The aim of the APOCP and its
official journal the APJCP is to promote an
increased awareness in all areas of cancer
prevention and to stimulate practical
intervention approaches. The scope is
wide-ranging, including descriptive, analytical
and molecular epidemiology, experimental and
clinical histopathology/biology of preneoplasias
and early neoplasias, assessment of risk and
beneficial factors, experimental and clinical
trials of primary preventive measures/agents,
screening and secondary prevention, and all
aspects of cancer prevention education.
Aims and Scope Asian Pacific Journal
of Cancer Prevention
Contents      - Volume 1      - Volume 2      -
Volume 3      - Volume 4    - Volume 5
   Constitution Information for APJCP Information
for Authors Information for Subscribers Events Mem
bers
APJCP Chief Editor - APOCP Chairman   Kazuo
Tajima Division of Epidemiology and Prevention,
Aichi Cancer Center, Research Institute 1-1
Kanokoden, Chikusa-ku, Nagoya 467-8681, Japan
Tel [phone], Fax [phone] Email
ktajima_at_aichi-cc.jp APJCP Managing Editor -
APOCP Coordination Director   Malcolm A
Moore Email apocp2000_at_yahoo.com  
Subject Editor - Education/Cancer Registration
Timothy J Threlfall (IARC Rep) Supannee
Sriamporn Subject Editor - Epidemiology Shinkan
Tokudome, Keun-Young Yoo Subject Editor -
Screening and Intervention You-Lin Qiao,
Iinuma Subject Editor - Toxicological Pathology
Hiroyuki Tsuda, Yogeshwer Shukla
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Areas of Interest
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Cancer Registration
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Descriptive Epidemiology Males
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Descriptive Epidemiology Females
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Prevalent Cancers
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Dietary Variation
Consumption of Major Food Groups Worldwide as
Percentages of Total Energy
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Histogenesis of Cancers and Prevention Timing
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Individual Body Sites
Cancer Type Prevalence over Time Risk
Factors Beneficial Factors Primary
Prevention Secondary Prevention Screening
Modalities
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Oral Cavity Cancer
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Site Distribution and Factors
Risk Factors Tobacco Betel Nut
Trauma HPV/EBV Diet Protective
Factors Antioxidants Oral Hygiene
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Distribution of Betel Chewing
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Histogenesis of Buccal Cancer
From Chiba, 2001 APJCP
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Oesophageal Cancer
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SCCAdenocarcinoma Ratios for Oesophageal Cancer
Country Location SCC AC Ratio China,
Tianjin 33.1 3.3 101 China, Hong Kong 84.5
9.3 91 India, Bombay 91.9 1.0 921 India,
Madras 86.0 11.8 71 Israel, All
Jews 69.9 23.5 31 Japan, Miyagi 92.2
3.2 291 Japan, Osaka 90.3 3.8 241 Philippines
, Manila 67.1 18.3 41 Australia,
NSW 54.3 38.5 11 Australia, Victoria 53.6 39.1
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Risk Factors
SCC Tobacco Opium Nutrient Deficiency
Cereal Intake Adenocarcinoma Obesity
Correlation between Cereal Intake and
Oesophageal Cancer
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Prevention
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Gastric Cancer
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(No Transcript)
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Risk and Protective Factors for Cancer of the
Gastric Cardia and Antrum
Factor Cardia
Antrum Risk Helicobacter /-
Epstein-Barr /- Gastric Ulcers
/- High Salt Diet High fat
Diet /- Obesity
/- Smoking Alcohol
Protective Vegetable Intake --
-- Data from the literature
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Prevention
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Colorectal Cancer
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Correlation between Cereal Intake and Colon
Cancer
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Dietary Factors
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Factors for Colon and Rectal Cancer
Factor Colon Rectum Risk High
fat Diet Obesity
/- Alcohol /- Protective Physical
Activity /- Fibre Intake
(Data from Food, Nutrition and the
Prevention of Cancer a global perspective,
World Cancer Research Fund/American
Association for Cancer Research)
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Colon or Rectal Cancer
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Prevention
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Hepatocellular Cancer
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Lung Cancer
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(No Transcript)
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Cancer Site Linkage Colon By Lung Adenocarcinoma
Incidence/100,000
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Molecular Biology
Pathology
Epidemiology
Cancer Registration Hospital-based
Population-based Risk/Beneficial Factors
Tobacco Dietary Factors Cooking
Environment Climate Lifestyle
Anthropomorphic factors Genetic Background
Lung Carcinoma Types Adenocarcinoma Hobnail
Columnar/Cuboidal Mixed Polygonal
Goblet Squamous Cell Carcinoma Tumour
Behaviour Background Disease
Parameters Mutations Transversions
Transitions Kinetics Apoptosis
Proliferation Cell cycle/Signalling Polymorphism
s
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Prevention
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Urinary Bladder Cancer
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Prostate Cancer
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Prevention
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Breast Cancer
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Age Dependence Mammary cancer
Registry Age class
25-34 35-44 45-54 55-64 65-74
China, Tianjin 4.5 15.5 15.8 13.5
6.9 India, Madras 1.8 8.2 9.7 7.6
4.4 Japan, Osaka 1.9 13.3 21.6 14.7 10.5 Philli
pines, Manila 5.0 15.8 16.8 12.9
7.0 Thailand, Khon Kaen 1.3 4.5 4.5 2.8
1.1 Viet Nam, Hanoi 2.7 9.1 11.0 5.1
1.1 Australia, Victoria 5.2 25.3 38.3 37.5 41.8
Incidence/100,000 x percentage of the female
population Data from Parkin et al., 1997
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Risk Factors
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Prevention
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Cervical Cancer
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Risk Factors
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Prevention
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Lifetime Cumulative Risk Japan
Data from Inoue and Tominaga, 2003 (APJCP)
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Potential for Prevention of Cancer
Incidence/Deaths in Japan
Sites Cancer control
Methods/assumptions Direct All Primary
prevention Smoking 17.5 8.8
Chemoprevention? Dietary 25.6 10.3 Infect
ion 13.9 7.0 Subtotal 26.1 Cance
r screening Participation rates for gastric,
colo-rectal, cervical, lung and breast
cancer 30 to 50 29.4 8.8-14.7 Improved
diagnosis/ treatment 5-year survival rate
elevated by 0.6 - 1.0 per year for 10 years
6.0-10.0 Total
40.9-50.8
Data after Tominaga, 2001 (APJCP)
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Practical Prevention Program
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Who and Where?
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Thank you!