Endo Chapter 1

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EndoChapter 1
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Basics

• Glands
• Hormones
• Target cells

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Hormones

• Lipids
• Proteins
• Amino acids
• Hormones have a variety of functions

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Reproduction

• LH and FSH
• Estrogen
• Testosterone
• Prolactin
• hCG

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Growth and Development

• GH
• Androgens
• Insulin
• IGFs
• Various other GF

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Maintaining Internal Environment

• Vasopressin
• Aldosterone
• PTH
• calcitonin

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Regulation of Energy Balance

• Feeding behavior
• Leptin
• Orexin
• ghrelin

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• Synthesis and release of hormones
• Preprohormone
• Signal peptide
• Can yield different active peptides
• Cryptic peptides no known bio activity
• Prohormone
• Signal peptide
• Exocytosis
• Difference in synthesis of amine/steroids and
  peptides

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Patterns

• Circhoral - 1 hour
• Ultradian between 1 and 24 hours
• Circadian 1 day
• Quotidian occurs every day
• Ciractrigintan - 30 days
• seasonal

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Transport

• Carrier proteins
• Used with steroids and thyroid hormones
• Exceptions (IGF)
• Some are specific (binding globulins)
• Albumins not as selective
• gtbinding ltclearance
• lt 1 of a hormone excreted intact
• Tends to be metabolized

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Feedback

• Negative
• Positive
• Forward

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Disease

• Deficiencies
• Overproduction
• Receptors
• tumors

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