Cerebral Volume by Group Age 3

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Cerebral Volume by Group- Age 3
p.004
p.001
Volume (cc3 SD)
DD Control (N14)
TD Control (N26)
ASD Autism (N45)
(Sparks et al. Neurology 2002)
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Sparks et al. Neurology 2002
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Structure/ Neurochemical Relationships in
Childhood Autism
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Background

• Spectroscopy
• We initially predicted that larger brains would
  be associated with increased neuronal packing
  density
• By MRS, we had expected
• ? neurochemical concentrations
• ? metabolite relaxation times

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Original Cellular Model
Neuron
Glial Cell
Control
Autism
MRS
Conc
20ms
20ms
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(Friedman et al. Neurology 2003)
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Regional MRS Summary

• In contrast to hypotheses of widespread densely
  packed neurons resulting from abnormal
  developmental processes, inverse relationships
  were demonstrated
• ? neurochemical concentrations
• ? metabolite relaxation times
• Alternative models in ASD for disordered cellular
  organization, distribution, or cytoarchitecture

(Friedman et al. Neurology 2003)
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MRI Segmentation
CLASSIFIED
MRI (N3)
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Fluoxetine Brain Concentration- Age Relationships
Strauss et al. Am Jr Psych 2002
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Fluvoxamine Brain Concentration- Age
Relationships
Strauss et al. Am Jr Psych 2002
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University of Washington
Wayne Strauss, MD PhD Bioengineering
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