Diagnoses Case1

1
Diagnoses Case1

•   
• - Idiopathic mastitis / granulomatous mastitis
• - Mastitis (eosinophil)
• - Lymphocytic mastitis
• - Chronic mastitis with ductal epithelial and
  myoepithelial proliferation
• - Tumor like granulomatous mastitis. Exclude
  Paget disease
• - Carcinoma
• - Granulomatous reaction
• - Granulomatous lobular mastitis with
  eosinophilia
• - Eosinophil mastitis (allergy? parasitic
  infection?)

2
Diagnoses Case2

•   Solid intraductal papilloma, with myoepithelial
  ductal proliferation
• - Ductal adenoma/complex sclerosing papillary
  lesion
• - Intraductal sclerosing papilloma
• - Solid intraductal papilloma
• - Papillary intraductal carcinoma arising in a
  papilloma
• - In situ papillary carcinoma
• -Carcinoma papillare intracysticum et invasion
  with DCIS
• - Intracystic papilloma with malignant change
• - Encysted papillary carcinoma
•  

3
Diagnoses Case3

•   Hamartoma mammae
• - Columnar cell change with mucin filled cysts
  and ADH
• - Proliferative mastopathy
• - Ductal papillomatosis
• - Fibrocystic change with columnar cell
  hyperplasia
• - Fibrocystic change with benign epithelial cell
  proliferation, with microcalcification
• -Complex sclerosing laesion. No malignancy. Mild
  dysplasia in the intraductal papillomatosis
  component
• - Hypersecretory hyperplasia
• - FCC DIN1a, c
• - DIN1a, mucin filled ducts, calcification

4
Diagnoses Case4

• Lobular carcinoma, solid variant, with apocrin
  differenciation
• - Invasive cancer (ductal, NST)
• - Collision lobular and ductal carcinoma, with
  pagetoid epidermal invasion
• - Invasive ductal carcinoma with skin
  infiltration
• - Invasive ductal carcinoma (diff. melanoma
  malignum?)
• - Carcinoma ductale exulceratum valde infiltrans
  with skin propagation, with lymphangio-invasion,
  and partial neuroendocrin differentiation
• - Melanoma or ducta lcancer, or mixed
• - Paget carcinoma

5
Diagnoses Case5

• Pleomorph lobular carcinoma
• - Lobular invasive carcinoma lymphocytic
  inflammation or lymphoid tumor
• - Invasive lobular carcinoma, pleomorphic
• - Invasiv lobular carcinoma sclerosing
  lymphocytic lobulitis
• - Mastitis granulomatosa, with infiltrative
  ductal-lobular carcinoma in the background
• - Inflammatory lobular-ductal cc.
• - Mixed lobular and ductal cancer
• - IDC
• - Pleomorph carcinoma high grade DCIS

6
Diagnoses Case 6

• Secretory carcinoma
• - Adenoid cystic carcinoma
• - Breast hamartoma
• - Cystic-secretory hyperplasia
• - Sclerosing adenosis (pleomorph adenoma-like)
• - Tubular carcinoma. Excision incomplete.
• - Sclerosing adenosis well differentiated
  tubular carcinoma
• - Apocrin carcinoma
• - Mucoepidermoid carcinoma

7
Diagnoses Case 7

• Invasive ductal carcinoma, with partial DCIS-like
  appearance, with extensive angioinvasion
• - Invasive carcinoma (ductal, NST with clear cell
  areas (glycogen rich?)
• - Acinus sejtes carcinoma
• - Invasive glycogen-rich carcinoma
• - Ductal carcinoma- in situ and invasive
• - Comedo carcinoma and invasive ductal carcinoma
• - Carcinoma lobulare in situ (comedo-like foci)
• - Metastasis (clear cell carcinoma)
• - Clear cell carcinoma

8
Diagnoses Case 8

• - Malignant phylloid tumor
• - Malignant spindle cell tumour of the breast
• - Malignant phyllodes tumour
• - Sarcoma NOS
• - Spindle cell carcinoma
• - Myofibroblastoma
• - Well differentiated liposarcoma, spindle cell
  type
• - Phylloid tumor (borderline)
• - Phyllodes tumor - malignant low grade
• - Schwannoma
• - Pericytoma
• - Myoepithelioma
• - Spindle cell myoepithelioma

9
Diagnoses - Case 9

• - Intraductal papillary carcinoma
• - Papillary DCIS with minor cribriform
  component
• - Papillary intraductal carcinoma
• - Cystic papillary in situ carcinoma
• - Intracystic papillary carcinoma
• - In situ papillary carcinoma

10
Diagnoses Case - 10

• - Complex sclerotising laesion
• B2 (sclerosing adenosis, cyst, usual type
  hyperplasia as parts of the fibrocystic changes
  spectrum, a diagnosis probably lacking
  correlation with the clinical presentation)
• Fibrocystic change with hyperplastic lesions
• - Sclerosing adenosis
• - Benign (sclerotising adenosis)
• - Intraductal dysplasia
• - Mastopathia fibrocystica
• - Epitheliosis
• - UDH
• - Adenosis
• - Radial scar. B3

11
Diagnoses Case 11

• -Invasive well differentiated ductal carcinoma
• - B5 Invasive carcinoma
• - Cribriform or tubular carcinoma
• - Invasive ductal carcinoma, NOS
• - Invasive ductal carcinoma
• - Carcinoma cribriforme
• - Carcinoma lobulare-ductale
• - Carcinoma
• - IDC
• - Invasive carcinoma with DCIS component. B5

12
Diagnoses Case 12

• -not suitable for diagnosis
• - B5 Invasive carcinoma
• - Carcinoma invasivum mammae
• - Tissue unsatisfactory for interpretation
• - not assessable, may be benign
• -Inflammatory carcinoma (poorly differentaiated
  ductal carcinoma) in a background of
  granulomatous mastitis.
• - Malignant soft tissue tumor
• - Small fragment malignant epithelial tumor,
  Immunhistochemistry necessary
• - Malignant tumor. B5