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OVERVIEW OF THE DAN! - BIOMEDICAL APPROACH
       
By Dr (Mrs) Doris N. Izuwah OLG Foundation and
Autism Centre, Port Harcourt, Nigeria
Based on Work by Bernie Rimland, Ph. D (RIP)
Sidney Baker, MD My Mentor Jon B. Pangborn,
Ph. Martha Herbert, MD,PHD Anju Usman My Colla
borator Janelle Love My Mentor
       
 
 
 
Dedicated to ASD Children and their Families
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HOPE THROUGH EDUCATION With more education
and awareness more preventative measures,
diligent actions and more recoveries to save a g
eneration of children
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WHAT YOU NEED TO KNOW

• Why is he/she autistic?

• Can autistics recover?

• When does the DAN approach work?

• Why is autism a biomedical problem?

• Why is it so difficult to reverse?

• How do you do it?

But first, a bit of history
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DAN! FOUNDED BY Bernard Rimland, Ph.D - Late
Director, ARI
Jon Pangborn, Ph.D, - Bionostics Inc.
Sidney
Baker, MD., NY DAN is 12 this year. Was started
because of the belief that autism is treatable
and not an incurable lifelong disability needing
mgt with psychiatric drugs. The three gents
mentioned above deeply believed that there are
metabolic, biomedical, immunological and
gastrointestinal abnormalities in children with
autism. Repairing these abnormalities can lead to
recovery from autism.DAN is made up of
knowledgeable scientists, researchers and parents
whose mission is to provide parents and
professionals with a timely consensus as to the
safest and most effective treatment options for
children with developmental problems in the
autism spectrum. In order to accelerate
the development and dissemination of information
that will be helpful to doctors and families of
children with autism, ARI convened the first DAN
conference in Dallas in 1995 .Currently, DAN
organizes bi-annual conferences, that helps to
produce a base of physicians who employ rational
and scientifically sound approaches to the
diagnosis and treatment of autism.
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DAN APPROACH AUTISM MYTHSNo emotions- they do
have emotions Too loud, bright and crowded
thereby needing spanking- not trueRefrigerator
mothers by Beithleheim- biomedical
issuesChildren are born with autism No
diagnosis average 44 monthsVaccines play no
role in autism only when the Hg is
removedAutism is a rare disorder now 1 in 150
US Data (every 16mins)Autism is only manageable
Autism is treatable and full recovery is
possible especially with early interventionGenet
ically determined and brain based Environmental
factors acting on a genetic predisposition/vulnera
bility to injure tissues in the brain and body
that affect behavior ie. There genetic influence
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WHY IS MY CHILD AUTISTIC

• PRE EXISTING
• WEAKNESS
• GSH Metabolism
• Folate and Vit B12
• chemistry
• Metallothionein
• dysfunction
• Detoxification pathway
• impairment
• - Sulphation pathway
• - Methylation pathway
• - Oxidative stress
• Enzyme deficiency
• DPPIV, Gastrointestinal

• STRESSORS
• Heavy metal toxicity,
• Environmental toxins insult and chemicals
• Viral infections- measles, polio, CMV
• Yeast infections - Candida, molds
• Bacterial infections like, streptococcus
  infection (PANDAS), gram negative rods,
  clostridia
  
• Others Lyme, chronic inflammations, overuse of
  antibiotics, brain/immune dysfunction
  
  
• The body may produce antibodies to these agents.
  These antibodies may then cross react with our
  own tissues creating an autoimmune reaction
  molecular mimicry

.
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Heavy Metal Toxicity and Toxic Environmental
Pollutants

• Heavy metals mercury, lead, cadmium, aluminum
• antimony
• MERCURY
• Causes DNA damage across the BBB and inhibits
• mononuclear phagocytosis.
• Destabilizes the thiol chemistry and injures
  methylation,
  
• adversely affecting a child's biochemistry
  and immunologic integrity.
  
• Inhibits and inactivates methionine synthesis
  which is important for the GSH synthesis
  
• Inhibits DPP4/CD26 , adenosine metabolism,
• Destroys the intestinal tract and can increase
  its permeability leading to leaky gut syndrome
  
• POTENTIAL OUTCOMES
• Autism, failure to thrive, increased salivation
  ,poor
  
• eye contact, disinterested, pink disease, Brain
• damage\mental retardation, incordination,
  blindness,
  
• seizures or tremors, sensory disturbances, vision
  and
  
• hearing changes, memory problems ,irritability,
• inability to speak, lung damage, nausea,
  vomiting,
  

• PERSISTENT ORGANIC
• POLLUTANTS (POPs)
• Pythalates, pesticides,
• herbicides, bisphenol,
• PCBs, PBDE,DDT
• Difficult to detox, stored
• in fat indefinitely,
• interferes with hormonal
• signals that regulate
• human organ
• development, damages
• DNA, harm developing
• nervous system,
• carcinogenic, and causes
• genital malformation,
• allergies, asthma,

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Anger/fear Immune dysfunction
Antibiotics abuse
Early introduction of food
Stress
Undigested food serves as a substrate
Yeast Bacteria Viral Parasitic infections
competing for adhesion sites and modifying t
he
intestinal environment.
Intestines Susceptible To colonization by pat
hogenic
organisms
Crowd out protective flora by alters the com
mensal flora
Disrupts Beneficial flora
Specific Ailments/ autistic symptoms
Increase intestinal permeability
Gut inflammation
dysbiosis
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GLUTATHIONE METABOLISM, METHYLATION, FOLATE AND
VIT B12 CHEMISTRY
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Metallothionein Dysfunction ( MT)

• MT is a short linear, s-shaped chain of A.A rich
  in cysteine. Each MT binds up to 7zn 13 Cu,
  Found in high levels in hippocampal region in the
  brain - impt area of learning, memory behavior
  control. Also in Amygdala - impt in development
  of socialization skills and emotional memory.
  Impairment or damage of the brain before 3 yrs
  decreases its fxn
• Ferries zn into peripheral tissues, aids in the
  immune cells in thymus and lymphoid system. The
  Zn also activate DPP4 that breaks down
  caseomorphins and gluteomorphine.
• Excellent antioxidant - neutralizes the excess
  H2O2 toxins produced after killing of
  bacteria/viruses by WBC. Binds tightly to heavy
  metals and renders them harmless
• Binds cu therefore reducing its effect on short
  term memory failure, concentration reduction,
  anxiety impulsive behavior.
  

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Metallothionein Dysfunction ( MT)

• In the intestine, it functions in the synthesis
  of digestive enzymes carboxypeptidase,and amino
  peptidase which breaks down proteins, enhance the
  production of stomach acids, protects against
  inflammation. In pineal gland, it manufactures
  melatonin which normalizes sleep
• Regulates taste texture discrimination on the
  tongue
  
• Female hormone induces the manufacture of MT
  while testosterone enhances the toxicity of
  mercury.
  
• Destabilized by Zn depletion, abnormal GSS
  system, deficiency in cysteine, genetic mutation,
  toxic metals , excess cu, inflammation,
  infections, stress, free radicals

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.

• Methylation Pathway - Necessary for the way for
  energy delivery and activation of electochemical
  processes that are required for cellular
  (neuronal) perception and responses

• Glutathione - Major antioxidant, plays a major
  role in detoxification esp Hg, helps regenerate
  epithelial cells, potentiates methylation
  
• Consequences of decreased GSH -- decreases
  detoxification, degeneration of gut epithelium
  leading to increased permeability and
  autoimmunity, abnormal immune function, decreased
  antioxidant capacity
• Aids GSH Vit B12
• Inhibits GSH Hg

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FINAL COMMON PATHWAY

• d

allergens
Heavy metals
radiation
Different combination of environmental inputs co
verage on the same pathway This may overwhelm
the systems in
similar ways
chemicals
stress
noise
toxins
infections
drugs
The body defense and coping system
gut
lungs
immune
Detox liver
EPIGENETICS Genes Timing Specific agents Back
ground state
The bodys generic reactions Inflams epigenet
ic methylation
GSH
Oxidative stress Impaired deto
xification -
Specific disease
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DAN! BIOMEDICAL APPROACH Summary
Autistic Children are individuals treat the i
ndividuals problem! the childs autism is not a
single entity its a spectrum of disorders with
multiple contributing causes. To proceed, all y
ou have to do is decide what do
we do next ? Dont try to do everything at once.
Always proceed with care. Take one step at a ti
me. For professionals listen to parents, they a
re your teachers. Do all you can for the child
but please do no harm.
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Literature Information

• Decrease in PKU due to screening in neonates
• Scientific Foundations of a Biomedical
• Approach to ASD Autism Effective Biomedical
  
  
• Treatments, by Jon B. Pangborn, Ph.D. and
• Sidney M. Baker, M.D., Oct. 2005, this manual
  
  
• has revolutionized the biomedical approach in
  
  
• the diagnosis and treatment of autism, PDD
• and related disorders.
• http//www.autismwebsite.com/ARI/dan/scientificfo
  undations.htm Compilation of Studies Supporting
  the Biomedical Approach

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DOES IT ALWAYS WORK

• Severe inborn errors of metabolism missing or
  damaged genes Retts Syndrome, Fragile X Cerebal
  Palsy and others NOT CORRECTABLE (YET), SOME
  IMPROVEMENTS MAYBE

• But - not forever. PKU featured autism in 40
  now now PKU autism is very rare.

• MOST TODAY, AUTISTIC CHILDREN CAN RECOVER OR BE
  SIGNIFICANTLY IMPROVED.

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LABORATORY INVESTIGATIONS

• Basic lab test e.g. FBC, Urine M/C/S, ESR, WBC
  total and differential, Platelet count, LFT, Urea
  S/E/C, Viral titer,
  
• Urine Organic and Amino Acids
• Heavy metal toxicity assay and blood
  elements/minerals
  
• Allergy and Hormone profiles
• Fatty acid screen and Comprehensive Stool
  Analysis
  
• Auto antibodies and Genetic testing
• Immune markers and Umbilical cord blood analysis
• Meconium analysis of fetal exposure to
  environmental toxins etc etc

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WHAT TO DO

• Remove the stressors
• Reset metabolic priorities
• Support desired biochemistry and immunology

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.
Heal the gut Digestive enzyme Cod liver oil Col
ostrum
Glutamine probiotic
Trials of GF,CF,SCD Remove other sources Of foo
d allergy
Clean up diet/ environment, Bring toxin load dow
n
investigation Treat specific ailment Immune sup
port selenium Zn ,co enzyme Q 10 Anti oxidants
Vit C/E
Treat dysbiosis And infection Anti fungal Antib
acteria
Antiviral Probiotic s. boulardi
Basic nutritional Supplementation Zn, Mg, Ca,
Vit B12,
Vit B6,
ABA Son rise CARD VB TEACH Floor time
Detoxification DMSA DMPS Ca EDTA Natural ga
rlic,
leek etc
Improve broken biochemistry Support methylation
TMG, Glutathione ,MB12
Folinic acid
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Clean Up Your Environment - 1

• Use natural biodegradable and perfume free
  detergents and cleaning agents.
  
• Avoid chlorine, use water filters, limit pool and
  hot tubs
  
• Wear 100 cotton clothes, avoid flame retardant
  materials (antimony)
  
• Use fluoride free toothpaste
• Avoid playing on pressure treated woods
  (arsenics)
  
• Eliminate exposure to HG
• Use an air purifier esp. in the bed room
• Avoid prolonged exposure to batteries

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Clean Up Your Environment - 2

• Avoid plastic furniture (polyvinyl chloride)
• Use Al free baking powder, deodorant, do not cook
  nor drink from Al cans and cups
  
• Avoid use of herbicides or pesticides on lawns,
  gardens or home
  
• Use natural shampoos, soaps and make up (lipstick
  Pb, foundation Bi)
  
• Use house plants like aloe Vera, elephant ear
  philodendron, English ivy, peace lily, spider
  plant, ficus (the help to remove benzene, co,
  formaldehyde)

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CLEAN UP THE DIET - 1

• GFCF diet trial for 3-6mths
• Avoid sugar refined starch, give high protein,
  high fiber diet, high good fats, maximize
  antioxidants, increase cruciferous veggies,
  garlic, turmeric and fermented foods.
• Limit processed and preserved foods, organic is
  best
  
• Avoid excitotoxins eg. caffeine, MSG,
  NutraSweet, red/yellow dyes, nitrites, sulfites
  ,glutamates preservatives,
  
• Limit intakes of phenols
• Limit source of copper (chocolate, shell fish,
  tap water, food dyes)

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CLEAN UP THE DIET - 2

• Drink plenty of filtered water
• Never microwave in plastics or Styrofoam, do
  not store food in plastics or foil
  
• Eliminate sea food and avoid genetically
  modified foods
  
• Begin meals with raw fruits or veggies
• Use sunflower oil for all cooking
• Buy hormone free, antibiotic-free organic
  meat.
  
• Use stainless steel for all cooking and use
  stainless steel cutlery

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DETAILED BIOMEDICS FOR ASD TREATMENT

• Basic Nutritional support Zinc
  2-3mg/kgMagnesium 10-30mg/kgSelenium
  100-200mcg/dayMolybenum 100-250mcg/dayCalcium
  200-1000mg/day
• AntioxidantsVitamin C 500-1500mg/dayVitamin
  E 200-800iu/dayVitamin A 2500-15,000iu/dayEFAOm
  ega 3 EFA 1000mg
  
• VitaminsB6 50-500mg or P5P 12.5-100mgB
  Complex Vit B6, Vit B 12,

• Treat Dysbiosis Antifungal, anti parasitic,
  anti bacteria
  
• Anti fungals
• -Non Absorbable -S. Boulardii
• Amphoteracin B
• -Absorbable - Sporanox diflucan,Lamisil ,Nizoral
• -Others Candex, candigest
• Digestive Aids enzymes like
• DPP4, phenol assist,

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DETOXIFICATION Remove/avoid all sources of heav
y metal/toxinsSupport detoxification pathway
Phase 1 - Make toxin sticky-cyt P450
Phase 2 - Attach to a sticky usher by
conjugation e.g.SO4, GSH, Methylation,
acetylation, glycination, Taurine conjugation
using supplements, things that help with thiol
chemistryso4, M12, vit, min , Selenium,
silimanrin, milk thistle, vit D
or induce with super foods like pomegranate
juice, green tea, acai Veggies like broccoli, Bru
ssels spouts, cabbage, radish Alium family- garli
c, leek, chive, spinach, Phase 3 Chelators
- bind a free metal ion into a ring structure
thereby neutralizing its reactive
state e.g. DMSA , EDTA , DMPS ,PCA RX
Natural Liver Detox Support e.g. Glutathione
, Methylcobalamin/methyl B12,
Alpha Lipoic Acid N-Acetyl Cysteine,
TTFD/Allithiamine Herbals (garlic, cilantro,
chlorella, spirulina) RNA Therapy - Home
opathic - Far infra-red Sauna
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.
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WEYOU CAN DO IT

• Listen, learn and ask questions
• Read the book DAN MANUAL
• Seek professional help
• Each child with autism is an individual
• Proceed carefully
• One step at a time
• Keep records
• Their might be regression
• You can do it
• Talk to, and reassure the kids, they are
  listening.
  
• Let others/parents educate you
• HARD QUESTION - Have we done every thing we can
  for this child? DONT EVER LOOSE HOPE

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THANK YOU ALL SPECIAL THANKS
TO FILOMENA AREC FOR SPONSORING MY
TRIP FROM NIGERIA TO SWEDEN WE AT OLG HEALTH FO
UNDATION AUTISM CENTRE NEED YOUR HELP WITH FUN
DING.WE HAVE OVER 50 CHILDREN WE HAVE CONSULTED
FOR WHO ARE AUTISTIC BUT WE CANNOT PROVIDE ANY
CARE DUE TO LACK OF FUNDING ..PLS HELP US WITH
FUNDING OR DIRECTIONS TO OTHERS WHO CAN HELP FUN
D US. Our website www.olgautismnigeria.org and
Yahoo group defeatautisminnigeria_at_yahoogroups.co
m My Email dorisizuwah_at_yahoo.com or dorisi_at_olga
utismnigeria.org or info_at_olgautismnigeria.org