SureGene LLC: Mission Statement

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SureGene LLC Mission Statement
SureGene, LLC is committed to improving the
lives of sufferers of psychiatric illnesses and
their family members by removing the guesswork
from diagnosis and treatment of these oppressive
diseases
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SureGenes Business Model

• Create genetic tests for mental illnesses
• Select and support marketing partner(s)
• Create a one-stop shop of genetic testing for
  psychiatric illnesses
• Establish IP position in schizophrenia
• Expand to bipolar and other indications

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SureGenes History

• Pre-SureGene
• Basic research - 10 years and 5.3 million
• Utilized unparalleled sample set
• Founders met in 1999

• SureGene
• 2004 company officially formed
• 2005 first worldwide patent filed
• 1.0 million in company funding to date

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SureGenes Competitive Advantage Locus-Lock

• Whole genome QTL scan on normal population
• Focus on endophenotypes
• Identify high impact targets
• Confirm in familial cases
• Replicate in case controls
• Deliver test to partner

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Locus-Lock Schizophrenia

• Identified large number of potential genes for
  schizophrenia
• COMT, DISC1, NRG1, DTNBP1 examined but all ranked
  low in terms of impact as QTLs
• Confirmed and replicated 6 novel high-impact
  genetic regions in clinical samples
• Patents have been filed or are in-process for all
  6 regions

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SureGenes Product PipelineAssureGeneTM Test
for Schizophrenia
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The FITness Test Valuing Diagnostics
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The FITness Test AssureGeneTM Test for
Schizophrenia
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Management Team CEO - Tim Ramsey, MS, MBA

• Strategy Consultant and CFO Neuroscience
  Discovery, Eli Lilly
• Co-authored white paper on biomarker strategy
• Personalized medicine expert
• Participated on all pre-phase III neuroscience
  drug development teams
• Valued all pre-phase III neuroscience assets
• 16 years of entrepreneurial experience including
  3 biotech start-ups
• MBA University of Chicago
• MS in Biochemistry and Molecular Biology
  University of Louisville School of Medicine

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Management Team CSO - Mark Brennan, Ph.D.

• Lead inventor of AssureGeneTM and sole inventor
  of Locus-LockTM
• Co-founded Center for Genetics and Molecular
  Medicine at University of Louisville
• Earned 7.8 million in grant funding
• Including 498,000 Phase I SBIR from NIMH for
  SureGene
• Ph.D. in Genetics from Indiana University

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Scientific Advisory Board Chairman - Herbert
Meltzer, MD

• 700 publications for schizophrenia and related
  disorders
• Leading investigator for the first atypical
  antipsychotic, Clozapine
• Director of the research grant review program for
  the National Alliance for Research in
  Schizophrenia and Depression (NARSAD)
• Awards
• In 2005, the American Psychiatric Association
  presented Meltzer with its prestigious Award for
  Research in Psychiatry, a lifetime achievement
  award
• Daniel Efron Research Award of The American
  College of Neuropsychopharmacology

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SureGene
Contact Information Timothy L. Ramsey,
CEO SureGene, LLC 1044 E. Chestnut St, Suite
7 Louisville, KY 40204 Email tim.ramsey_at_suregene
.net Phone [phone]