Asymmetric Metathesis of Olefins with Molybdenum Imido Alkylidene Complexes

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Asymmetric Metathesis of Olefins with Molybdenum
Imido Alkylidene Complexes

• rrs_at_mit.edu
• richard.schrock_at_chem.ox.ac.uk

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Synthesis of a Substituted Binaphtholate Ligand
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Some of the things to come
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The First Nitrogen-Containing Substrates
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Synthesis of Supported Catalyst
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Diolate Failures
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Asymmetric Metathesis Publications"Chiral
Mo-Binol Complexes Synthesis, Structure,
Activity. Efficient Enantioselective
Six-Membered Ring-Synthesis Through Catalytic
Metathesis"Zhu, S. S. Cefalo, D. R. La, D. S.
Jamieson, J. Y. Davis, W. M. Hoveyda, A. H.
Schrock, R. R. J. Am. Chem. Soc. 1999, 121,
8251."Tandem Catalytic Asymmetric Ring-opening
Metathesis/Cross Metathesis"La, D. S. Ford, J.
G. Sattely, E. S. Bonitatebus, P. J. Schrock,
R. R. Hoveyda, A. H. J. Am. Chem. Soc. 1999,
121, 11603."Catalytic Asymmetric Tandem
Ring-Opening Metathesis / Ring-Closing
Metathesis" Weatherhead, G. S. Ford, J. G.
Alexanian, E. J. Schrock, R. R. Hoveyda, A. H.
J. Am. Chem. Soc. 2000, 122, 1828."Synthesis of
Molybdenum Imido Alkylidene Complexes that
Contain 3,3'-Dialkyl-5,5',6,6'-tetramethyl-1,1'-bi
phenyl-2,2'-diolates (Alkyl t-Bu or Adamantyl).
Catalysts for Enantioselective Olefin Metathesis
Reactions" Alexander, J. B. Schrock, R. R.
Davis, W. M. Hultzsch, K. C. Hoveyda, A. H.
Houser, J. H. Organometallics 2000, 19,
3700."Modular Mo-based catalysts for efficient
asymmetric olefin metathesis. Catalytic
enantioselective synthesis of cyclic ethers and
acetals"Weatherhead, G. S. Houser, J. H. Ford,
J. G. Jamieson, J. Y. Schrock, R. R. Hoveyda,
A. H. Tet. Lett., 2000, 49, 9553-9559."Catalytic
Asymmetric Olefin Metathesis"Hoveyda, A. H.
Schrock, R. R. Chem. Eur. J. 2001, 7,
945-950."Enantioselective synthesis of
Unsaturated Cyclic Tertiary Ethers by
Mo-Catalyzed Olefin Metathesis" Cefalo, D. R.
Kiely, A. F. Wuchrer, M. Jamieson, J. Y.
Schrock, R. R. Hoveyda, A. H. J. Am. Chem. Soc.
2001, 123, 3139-3140."A Readily Available and
User-Friendly Chiral Catalyst for Efficient
Enantioselective Olefin Metathesis" Aeilts, S.
L. Cefalo, D. R. Bonitatebus, Jr., P. J.
Houser, J. H. Hoveyda, A. H. Schrock, R. R.
Angew. Chem., in press.
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