Quotes of the day

1
Quotes of the day

• Now I know what a statesman is he's a dead
  politician. We need more statesmen.
• Bob Edwards
• Ninety percent of the politicians give the other
  ten percent a bad reputation.
• Henry KissingerUS (German-born) diplomat
  scholar (1923 - )
• An honest politician is one who, when he is
  bought, will stay bought.
• Simon CameronUS financier politician (1799 -
  1889)

2
Smooth muscle the problem

• Regulate dimensions, pressure and motility for
  hollow organs in the absence of skeletal support.
• Coordinated regulation
• Sustained activity with low energy expenditure

3
Tonic vs phasic activity
4
Orientation contributes to function
Seminiferous duct
arteriole
intestine
5
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6
Compare contractile filament orientation to
sarcomeres in skeletal muscle
Sparse sarcoplasmic reticulum Absence of t tubules
7
Orientation of contractile elements leads to
three dimensional contraction
8
Regulation
Compare to excitation of motor endplate of
skeletal muscle.
9
Single unit vs multiunit
10
Calmodulin rather than troponin as the regulatory
calcium binding protein
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12
Caldesmon regulates actin availability
13
Activation of PKG inhibits contraction
14
In tonic contraction, force is sustained for long
periods of time Energy cost?
15
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16
Quotes of the day

• It usually takes more than three weeks to prepare
  a good impromptu speech.
• Mark TwainUS humorist, novelist, short story
  author, wit (1835 - 1910)
• I wish people who have trouble communicating
  would just shut up.
• Tom LehrerUS humorist, singer, songwriter
  (1928 - )

17
Velocity is dependent upon phosphorylation over a
wide range of phosphorylation levels, but stress
is maximal at about 30 phosophorylation
18
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