Repair by connective tissue

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• Section 2
• Repair by connective tissue

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• Proliferation of fibroblasts and capillary
  buds and the subsequent laying down of collagen
  to produce a scar is the usual consequence of
  most tissue damage.

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• 1. Definition
• This is young connective tissue, which is rich
  in young fibroblasts and capillaries
• 2. Morphology
• (1) gross feature pink, soft, moist, and
  granular appearance.

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• (2) LM
• ? fibroblasts
• ? new capillaries capillary sprout and migrate
  toward the wound. The new capillary endothelial
  cells are swollen and capillary tubes are narrow.
  These new vessels have leaky interendotheial
  junctions. Allow the passage of proteins and red
  cells into the extravascular space, thus, new
  granulation tissue is often edematous.
• ? inflammatory cells

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Granulation tissue (Provided by prof. Song
W.Wong)
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Scar tissue
Scar tissue
(Provided by prof. Orr)
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3. Consequences
Granulation tissue
fibroblasts
New capillaries
Inflammatory cells
vascularity diminishing
collagen fibres
gradually
fibrocytes
Bonding and weaving
disappear
disappear
Scar tissue
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4. Function

• (1) anti-infection and protecting the surface of
  wound.
• (2) organization granulation tissue replace
  necrotic tissue, blood clot, and foreign bodies.
• (3) encapsulation
• (4) filling wound or loss of tissue.