A progressive, universally prevalent physiologic process producing measurable changes in the structure and decremental alteration in the function of tissues and organs.
(Miller, Anesthesia (4th ed.)
5
Physiologic or functional age is not always consistent with chronological age
Chronological age remains the best predictor of age related changes in organ systems or proximity to death
6 Body Composition Changes
Anatomic
increased lipid fraction
loss of muscle mass
Implication
increased half life for lipid soluble drugs
decreased O2 consumption, heat production
decreased cardiac output
7 Nervous System Changes
Anatomic
loss of neurons
reduced neurotransmitter activity
Implication
deafferentation
neurologic atrophy
decreased anesthetic requirement
8 Cardiovascular Changes
Anatomic
Decreased arterial elasticity
Ventricular hypertrophy
Reduced adrenergic responsiveness
Implication
Increased resistance to ejection
wide pulse pressure
decreased maximal cardiac output
9 Pulmonary Changes
Anatomic
Loss of lung elasticity
Increased thoracic stiffness
Reduced alveolar surface area
Implication
Increased residual volume
Loss of vital capacity
Impaired gas exchange
Increased work of breathing
10 Reduced Oxygenation
PaO2 102 - Age
3
11 Hepatic Changes
Anatomic
Reduced tissue mass
Implication
Reduced hepatic blood flow
Reduced drug metabolism
12 Renal Changes
Anatomic
Reduced vascularity
Tissue atrophy
Implication
Decreased plasma flow
Decreased GFR
Decreased drug clearance
Decreased ability to handle salt and water loads
13 Common Procedures in Patients Over Age 65
Thoracic or cardiac
Orthopedic
Craniotomy
Genito urinary
14 Common Procedures in Patients Over Age 65 (Contd)
Gynecologic
Cataract
Hernia repair
Pacemaker insertion
15 Special concerns for the geriatric patient 16 Skin
Loss of connective tissue
Bruise easily
Removing tape an electrodes may tear the skin
Tourniquets and BP cuff may cause a bruise
Heating pad may cause burn
17 Joints and Pressure Points
Lithotomy position
Nerve stretch injury
Dislocation of prosthetic hip
Lateral or Prone
Brachial plexus injury
Neck injury
Eye injury
18 Difficult Airway
Stiff neck and jaw
Dental deterioration
Difficult mask fit
Risk for aspiration
19 Dose and Duration of Drugs
Altered body composition
Decreased blood volume
Decreased muscle mass
Decreased plasma proteins
Slower circulatory time
Reduced metabolism and clearance
20 Why are they always cold when they get to the recovery room? 21 Surgical Patients Are
Undressed
Placed in a cold room
Washed with a cool liquid
Vasodilated
22 Altered Body Temperature
BMR decreased 1 per year after age 30
Decreased thermogenesis capability
23 Is Hypothermia Harmful?
Shivering requires energy
May cause myocardial ischemia
Drug metabolism is slowed
Note Expect elderly patients to be cold and plan to warm them
24 The Elderly Patient in the PACU 25 Complications to anesthesia may occur in almost 25 of patients in the PACU 26 Common PACU Complications
Pain
Nausea
Respiratory
Cardiovascular instability
27 PACU Complications (Contd)
Temperature changes
Fluid and electrolyte imbalance
Drug interactions
Cerebral dysfunction
28 Postoperative Pain
75 of postsurgical patients are undertreated for pain
Early pain management reduces other immediate postoperative problems
Strategies for postoperative pain control should be made prior to surgery
29 Geriatric Pain Control
Local infiltration
Intravenous narcotics
Bolus
PCA
Epidural narcotics
Non-Steroidal anti-inflammatory drugs
30 Complications to Pain Control
Over sedation
Respiratory depression
Agitation
Urinary retention
31 Nausea and Vomiting
Most common cause for admission of outpatient
Primary causes
The surgical procedure
Anesthetic agents
Premature administration of liquids
Motion
Pain
32 Prevention of Nausea
Delayed oral intake
Delayed motion
Pain control
Anti-Emetic drugs
33 Respiratory Considerations
Oxygen saturation of 90 or less occurs in 55 of PACU patients
Up to 95 of these episodes go unrecognized by the staff
Elderly patients tend to have a lower PaO2
34 Risk Factors for Hypoxemia
Duration of anesthesia
Surgical site
Age of patient
History of smoking
Type of anesthesia
35 Other Respiratory Complications in the Elderly
Bronchospasm
COPD
Allergy/anaphylaxis
Pulmonary embolism
Resuscitation
Pulmonary edema
Aspiration
36 Cardiovascular Problems
Hypotension
Residual anesthetic effect
Lack of stimulation
Fluid imbalance
hypovolemia
hypervolemia
Post-op epidural
Myocardial ischemia
37 Cardiovascular Problems (Contd)
Hypertension
Common in patients with arteriosclerosis
Exaggerated response to pain
All patients deserve pain control
Pain may worsen ischemia
Consider PCA
Consider full bladder
38 Cardiovascular (Dysrhythmias)
Causes
Increased sympathetic activity
Hypoxia
Hypercarbia
39 Dysrhythmias
Usually OK if rate 50 -90 and BP remains normal
Watch for
Bigeminy
Coupled PVCs
Re-entry phenomenon
May need to rule out MI
40 Fluid and Electrolyte Imbalance
Common problems in the elderly
Third space shift
Chronic anti-hypertensive treatment
TURP syndrome (hyponatremia)
41 Drug Interactions in PACU
Neuromuscular blocking effects of antibiotics are potentiated by Verapamil
Diuresis hypokalemia
Digitalis Toxicity
Clearance of Dilantin is reduced in the presence of the blockers
42 Drug Interactions in PACU (Contd)
Effects of Benzodiazepines and Propranolol are increased by Ranitidine
Beta Blockers or Digitalis combined with calcium channel blockers may lead to heart block
Ketamine plus Epinephrine may cause dysrhythmias
43 Drug Interactions in PACU (Contd)
The hypotensive effect of Labetalol is enhanced by Cimetidine and Halothane
Dilantin enhances the breakdown of Demerol
Propranolol plus Neostigmine enhances bradycardia
44 Mental Status Changes
Anatomic changes
Reduced brain mass
Cerebral sulci size increases
Neuronal loss 50,000 per day
Those producing neurotransmitters have the greatest loss
Decreased short term memory, auditory and visual acuity
45 Post-Op Mental Deterioration
Drug interaction or side effect
Depression
Cerebral vascular insufficiency
Metabolic imbalance
46 Summary
Elderly patients commonly have co-existing disease
Despite our best effort, elderly patients commonly arrive in the PACU cold with abnormal BP and/or respirations
47 Summary (Contd)
All patients deserve pain control
With a little extra care, elderly patients can be safely managed throughout the perioperative period
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