Moth Olfactory Reception

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Moth Olfactory Reception

• Pheromone Binding Proteins, Signal Specificity,
  and High Speed Behavior

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Overview Olfaction

• The pheromone blend

• Olfactory receptor neurons

• Whens the wizard getting back to you about
  that brain? or
• The Story of Glomeruli
• Interneurons and Ganglia
• Motor neurons
• Optomotor anemotaxis

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Focus

• How do airborne signals translate into action
  potentials in neurons?
• How does a pheromone molecule penetrate the
  sensillum lymph?
• Is odorant reception general or specific?
• How are pheromones received by ORNs?
• What happens to the pheromone molecule itself?

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Summary

• Pheromone molecules are received and transported
  through the hemolymph by PBPs
• PBPs undergo a conformational change and release
  pheromone to ORNs
• Pheromone in hemolymph is rapidly degraded by
  enzymes like APolPDE

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References

• Gräter, F., Xu, W., Leal, W., and Grubmüller, H.
  2006. Pheromone discrimination by the
  pheromone-binding protein of Bombyx mori.
  Structure 14 1577-1586.
• Gräter, F., de Groot, B.L., Jiang, H., and
  Grubmüller, H. 2006. Ligand-release pathways in
  the pheromone-binding protein of Bombyx mori.
  Structure 14 1567-1576.
• Konstantopoulou, M.A., Pratsinis, H., Kletsas,
  D., and Mazomenos, B.E. 2006. Pheromone-binding
  protein and general odorant-binding protein of
  Sesamia nonagrioides sex- and diel-dependent
  expression. Entomologia Experimentalis Et
  Applicata 119 129-136.
• Ishida, Y. and Leal, W. 2005. Rapid inactivation
  of a moth pheromone. Proceedings of the National
  Academy of Sciences 102 14075-14079.
• Leal, W., Chen, A.M., Ishida, Y., Chiang, V.P.,
  Erickson, M.L., Morgan, T.I., and Tsuruda, J.M.
  2005. Kinetics and molecular properties of
  pheromone binding and release. Proceedings of the
  National Academy of Sciences 102 5386-5391.
• Zubkov, S., Gronenborn, A.M., Byeon, I.-J., L.,
  and Mohanty, S. 2005. Structural consequences of
  the pH-induced conformational switch in A.
  polyphemus pheromone-binding protein mechanisms
  of ligand release. Journal of Molecular Biology.
  354 1081-1090.