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• Vicodin 750mg and Subutex 2mg

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Vicodin 750mg
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• This combination medication is used to relieve
  moderate to severe pain. It contains an opioid
  pain reliever (hydrocodone) and a non-opioid pain
  reliever (acetaminophen). Hydrocodone works in
  the brain to change how your body feels and
  responds to pain. Acetaminophen can also reduce a
  fever.
• Dosage-
• The dosage is based on your medical condition and
  response to treatment. In children, the dosage is
  also based on weight. Do not increase your dose,
  take the medication more frequently, or take it
  for a longer time than prescribed. Properly stop
  the medication when so directed.
• Pain medications work best if they are used as
  the first signs of pain occur. If you wait until
  the pain has worsened, the medication may not
  work as well.

3
Precautions-

• See also Warning section.Before taking this
  medication, tell your doctor or pharmacist if you
  are allergic to it or to other opioids (such as
  benzhydrocodone, hydromorphone, morphine,
  codeine) or if you have any other allergies.
  This product may contain inactive ingredients,
  which can cause allergic reactions or other
  problems. Talk to your pharmacist for more
  details.Before using this medication, tell your
  doctor or pharmacist your medical history,
  especially of brain disorders (such as head
  injury, tumor, seizures), breathing problems
  (such as asthma, sleep apnea, chronic obstructive
  pulmonary disease-COPD), kidney disease, liver
  disease, mental/mood disorders (such as
  confusion, depression, thoughts of suicide),
  personal or family history of a substance use
  disorder (such as overuse of or addiction to
  drugs/alcohol), stomach/intestinal problems (such
  as blockage, constipation, diarrhea due to
  infection, paralytic ileus), difficulty urinating
  (such as due to enlarged prostate), gallbladder
  disease, disease of the pancreas (pancreatitis).

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Side Effects-

• See also Warning section.Nausea, vomiting,
  constipation, lightheadedness, dizziness, or
  drowsiness may occur. Some of these side effects
  may decrease after you have been using this
  medication for a while. If any of these effects
  persist or worsen, tell your doctor or pharmacist
  promptly.
• Prevention-To prevent constipation, eat dietary
  fiber, drink enough water, and exercise. You may
  also need to take a laxative. Ask your pharmacist
  which type of laxative is right for you.To reduce
  the risk of dizziness and lightheadedness, get up
  slowly when rising from a sitting or lying
  position.

5
Overdose

• If someone has overdosed and has serious symptoms
  such as passing out or trouble breathing, give
  them naloxone if available, then call 911. If the
  person is awake and has no symptoms, call a
  poison control center right away. Symptoms of
  overdose may include slow/shallow breathing,
  nausea, vomiting, loss of appetite, sweating,
  stomach/abdominal pain, extreme tiredness, slow
  heartbeat, yellowing eyes/skin, dark urine, coma.

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Storage

• Store at room temperature away from light and
  moisture. Different brands of this medication
  have different storage needs. Check the product
  package for instructions on how to store your
  brand, or ask your pharmacist. Keep all
  medications away from children and pets. Do not
  flush medications down the toilet or pour them
  into a drain unless instructed to do so. Properly
  discard this product when it is expired or no
  longer needed. For more details, read the
  Medication Guide, or consult your pharmacist or
  local waste disposal company.

7
Subutex 2mg
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• SUBUTEX (buprenorphine) sublingual tablet is an
  uncoated oval white flat bevelled edged tablet,
  debossed with an alphanumeric word identifying
  the product and strength on one side. It contains
  buprenorphine HCl, a partial agonist at the
  mu-opioid receptor, and is available in two
  dosage strengths, 2 mg buprenorphine and 8 mg
  buprenorphine (as the free base, equivalent to
  2.16 mg buprenorphine hydrochloride USP and 8.64
  mg buprenorphine hydrochloride USP). Each tablet
  also contains lactose, mannitol, cornstarch,
  povidone K30, citric acid, sodium citrate and
  magnesium stearate.SUBUTEX is a prescription
  medicine used to treat adults who are addicted to
  (dependent on) opioid drugs (either prescription
  or illegal) as part of a complete treatment
  program that also includes counseling and
  behavioral therapy.

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Chemical Name

• Chemically, buprenorphine HCl is
  (2S)-2-17-Cyclopropylmethyl-4,5a-epoxy-3-hydroxy-
  6-methoxy6a,14-ethano-14a-morphinan-7a-yl-3,3-dim
  ethylbutan-2-ol hydrochloride. It has the
  following chemical structure

9
Dosage

• Under the Drug Addiction Treatment Act (DATA)
  codified at 21 U.S.C. 823(g), prescription use of
  this product in the treatment of opioid
  dependence is limited to healthcare providers who
  meet certain qualifying requirements, and who
  have notified the Secretary of Health and Human
  Services (HHS) of their intent to prescribe this
  product for the treatment of opioid dependence
  and have been assigned a unique identification
  number that must be included on every
  prescription.SUBUTEX is administered sublingually
  as a single daily dose.
• How supplied- SUBUTEX sublingual tablet is
  supplied as an uncoated oval white tablet in two
  dosage strengths
• buprenorphine 2 mg, and
• buprenorphine 8 mg

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Storage And Handling SUBUTEX sublingual tablet is
an uncoated oval white flat bevelled edged
tablet, debossed with an alphanumeric word
identifying the product and strength on one side
(B2 and B8 on 2 mg and 8 mg tablets
respectively), supplied in desiccated high
density polyethylene (HDPE) bottle NDC
12496-1278-2 (buprenorphine 2 mg/sublingual
tablet content expressed in terms of free base,
equivalent to 2.16 mg buprenorphine hydrochloride
USP) -30 tablets per bottle NDC 12496-1310-2
(buprenorphine 8 mg/sublingual tablet content
expressed in terms of free base, equivalent to
8.64 mg buprenorphine hydrochloride USP) -30
tablets per bottle Store at 25C (77F),
excursions permitted to 15-30C (59-86F). see
USP Controlled Room Temperature. Store SUBUTEX
securely and dispose of properly see Patient
Counseling Information.
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Side Effects-

• The following serious adverse reactions are
  described elsewhere in the labeling
• Addiction, Abuse, and Misuse see WARNINGS AND
  PRECAUTIONS
• Respiratory and CNS Depression see WARNINGS AND
  PRECAUTIONS
• Neonatal Opioid Withdrawal Syndrome see WARNINGS
  AND PRECAUTIONS
• Adrenal Insufficiency see WARNINGS AND
  PRECAUTIONS
• Opioid Withdrawal see WARNINGS AND PRECAUTIONS
• Hepatitis, Hepatic Events see WARNINGS AND
  PRECAUTIONS
• Hypersensitivity Reactions see WARNINGS AND
  PRECAUTIONS
• Orthostatic Hypotension see WARNINGS AND
  PRECAUTIONS
• Elevation of Cerebrospinal Fluid Pressure see
  WARNINGS AND PRECAUTIONS
• Elevation of Intracholedochal Pressure see
  WARNINGS AND PRECAUTIONS

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Overdose-

• Clinical Presentation- The manifestations of
  acute overdose include pinpoint pupils, sedation,
  hypotension, respiratory depression, and death.
• Treatment Of Overdose
• In the event of overdose, the respiratory and
  cardiac status of the patient should be monitored
  carefully. When respiratory or cardiac functions
  are depressed, primary attention should be given
  to the re-establishment of adequate respiratory
  exchange through provision of a patent airway and
  institution of assisted or controlled
  ventilation. Oxygen, IV fluids, vasopressors, and
  other supportive measures should be employed as
  indicated.