How Patients Can Benefit From Molecular Imaging

1
How Patients Can Benefit From Molecular Imaging

• Paula M. Jacobs, Ph.D
• Vice President
• Advanced Magnetics, Inc

2
How Patients Can Benefit From Molecular Imaging

• Probe basic biological and disease processes in
  animal models
• Identify therapeutic targets
• Identify prognostic factors
• Provide new clinical imaging agents for
• Diagnosis
• Therapeutic stratification
• Monitor response to therapy

3
MR Agent Development

• 50 M minimum and at least 10 years to develop a
  single diagnostic indication
• Reimbursement now around 45/dose
• Might be able to charge 100-200/dose
• About 1 million patients a year to even think
  about breaking even
• Example 10-12,000 new high grade glioma
  patients each year

4
Barriers to clinical availability of imaging
agents

• Small potential patient populations but ever
  increasing regulatory requirements
• Expensive pre-clinical manufacturing investment
  before trials
• Unpredictable regulatory climate
• Difficult reimbursement climate
• ? Poor commercial viability

5

• What can we do to make these targeted imaging
  agents available to small but important patient
  populations?