Hamburg St' Petersburg cooperation in the field of HSCT'

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Hamburg - St. Petersburg cooperation in the field
of HSCT.

• The twinning experience and results

Prof. B. Afanasyev (St.Petersburg, Russia) Prof.
D.h.c. A. Zander (Hamburg, Germany),
29 Annual Meeting of EBMT, Istambul, 2003
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Symbol of St. Petersburg, Saint Peter and Paul
Cathedral
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St. Petersburg Pavlov State Medical University
(founded in 1897)
Main administrative building of SPSMU
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Status in the field of HSCT and haematology in
the beginning of cooperation between twin-towns
St-Petersburg and Hamburg. (1989-1990, first
visits of Professor Axel Zander)

• There were few special clinics in ex-USSR, which
  would be in accordance with international
  standards for BMT performing, especially
  allogeneic BMT.
• The therapy results of children and adults with
  leukemia and other haematological diseases were
  significantly worse as compare to the same
  results in the West. For example the surviving
  in children with ALL in ex-USSR varied among
  10-20, in the West 50-70.
• There were no labs in accordance with
  international standard for HLA-typing,
  cryobiology, molecular biology, etc.
• Ministry of Public Health of ex-USSR didnt
  finance BMT-programme completely.
• Actually, there were few in ex-USSR specialists,
  who is familiar to technologies of BMT and
  modern chemotherapy.
• The international cooperation in ex-USSR in the
  field of BMT and Haematology was minimal but
  interest for BMT was extremely high after
  Chernobyl accident
• Levels of living of population, including medical
  professionals, during the first years of
  Perestroika was extremely low.

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Activity of Prof. A. Zander, Prof. K. Winkler,
Prof. G. Janka-Schaub and there colleagues from
Germany for improving situation in the field of
HSCT and Haematology in Russia

• Educational Program
• Transfer and modification of different modern
  chemotheraputic protocols to practical usage in
  St. Petersburg
• Extension of activity for organizing of different
  international meetings with participation of
  Russian specialists
• Integration of Russian specialists into different
  International medical and scientific program
• Help for supplying in medical equipments and
  medicines

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Main results

• About 60 doctors, scientists and nurses got
  possibility to be trained in Hamburg and others
  clinics
• Improvement of results of treatment of patients
  with different hematological and oncological
  diseases in St. Petersburg
• Transfer of modern scientific and clinical
  technology to St. Petersburg
• Establishment of cooperation with Universities of
  European countries and USA
• Integration into EBMT, IBMTR/ABMTR

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Zhenya (10 y.o) consulted by Prof. T. Buechner
before Bone Marrow Transplantation
Zhenya with her sister-donor 10 years after BMT
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Joint Russian-Germany BMT Clinic (EUFETS-SPSMU)
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O S of children with ALL
Prof. G. Janka-Schaub (Hamburg) and Dr. E.
Boichenko (St. Petersburg (2003)
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Prof. G. Janka-Schaub (Hamburg) and Dr. E.
Boichenko (St. Petersburg (2003)
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Bone Marrow Transplantation Activity from 1990
to 2002 (EBMT CIC 725)
Auto-BMT 205 Allo-BMT 70 Total 275
Adults- 200 Children-75
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Hematopoietic Stem Cells Transplantation in SPSMU
2001-2002.
n 121
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Event Free Survival after auto-HSCT. ALL
patients, age lt21
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Event Free Survival after auto-HSCT. AML
patients (1-2 remissions)
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Event Free Survival after allo-HSCT. CML
patients, age lt21
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Compare of Event Free Survival after allo-HSCT.
Age lt21
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Overall Survival after unrelated allo-HSCT.
Children with leukemia, age lt 21
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Project of Raisa Gorbacheva Centre of Children
Hematology and Transplantology SPSMU
Architecture workshop of Miturev Ltd.
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Cornerstone Ceremony, September 2002
Prof., Dr.h.c. A. Zander. Nobel Prize Winner, Mr
M. Gorbachev
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Conclusions

• International cooperation played the key role in
  improving the situation in development of
  BMT-program not only in St.-Petersburg but in
  Russia generally.
• Performing the Outreach Meeting during EBMT
  meeting seems to be very useful for development
  of BMT program in so-call countries in
  transition

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Acknowledgements

• We would like to express deep gratitude to our
  colleagues and friends from different European
  countries and USA for providing access to modern
  medical and scientific technology for the sake of
  our patients.