Senior Director, New Product R

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BioPhotonic ScannerClinical Applications
Carsten R. Smidt, Ph.D., FACN

• Senior Director, New Product RD

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What Do We Measure?

• Carotenoid antioxidants in stratum corneum

Carotenoids protect skin cells (DNA) from
harmful UV Light
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What Do We Measure?

• Skin Carotenoids Reflect Dietary Carotenoids
• The dietary assessment tool of the future
• Monitor fruit vegetable intake
• markers of fruit vegetable intake
• More convenient more accurate than blood
  carotenoids by HPLC
• Blood Short-term (last meals) transport
• Skin Long-term (last few weeks, months) site
  of action

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Why Do We Need Markers of Fruit Vegetable
Intakes?
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Skin Carotenoids

• The future of dietary health assessments
• Assess the efficacy of dietary changes
• Assess the efficacy of LifePak supplementation

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NSE In-House Study

• May - June 2002
• 1,266 employees, family friends
• Diet Lifestyle Questionnaire
• BioPhotonic Measurement
• Optional Free Radical Urine Test

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Mean 19,281 Std.Dev. 8,769 N 1,266
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What the Readings Mean

• Under 10 K Very Low Protection.
• Common reading for people eating unhealthy diets
  low in fruits and vegetables, and not taking
  antioxidant supplements.
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• 10 to 17.5 K Low Protection
• Common reading for people on average American
  diets and not taking antioxidant supplements.
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• 17.6 to 25 K Moderate Protection
• Common reading for people on better diets and/or
  taking antioxidant supplements.
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• Above 25 K High/Optimum Protection
• Common reading for people on healthy diets high
  in fruits and vegetables and/or taking highly
  effective antioxidant supplements.

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V. Low Low Mod. High/Optimum
Mean 19,281 Std.Dev. 8,769 N 1,266
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Gender Differences
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V. Low Low Mod. High
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Free Radical Test
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V. Low Low Mod. High
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Fruit Vegetable Intake
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LifePak Usage
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V. Low Low Mod. High
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LifePak Usage

• LifePak users have equal or higher scores than
  people on healthy diets (6 fr. veg.)
• 26,342 Six or more servings of fruits
  vegetables
• 28,848 LifePak, twice daily
• LifePak users score in the optimum range above
  25,000 units

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NSE Prospective LifePak Supplementation Study

• 30 employees who have not taken antioxidant
  supplements or LifePak within the last 3 months.
• 12 weeks on LifePak
• Measure BioPhotonic response every 4 weeks.
• Diet Lifestyle Questionnaire

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V. Low Low Mod. High
p lt 0.01
p lt 0.01
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n 25
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Individual Variability

• BioPhotonic measurements vary
• Your Genetic ability to absorb carotenoids
• non-responders, weak strong responders
• Your diet Fruit and vegetable consumption
• Your environment Oxidative stress weakens
  antioxidant network and reduces skin carotenoids

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Non-Responders

• Less than 1 out of 20 people
• No change with LifePak?
• Dont worry You will absorb all other
  antioxidants in LifePak
• based on two double-blind clinical studies

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LifePak Clinical StudyFASEB Journal 1999
Vol.13(4) A546
Serum Vitamin E
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LifePak Clinical StudyFASEB Journal 1999
Vol.13(4) A546
Serum Vitamin C
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LifePak Clinical StudyFASEB Journal 1999
Vol.13(4) A546
Inhibition of LDL Oxidation
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LifePak 40 Antioxidants

• 6 Carotenoids (15 mg total)
• 6 mg beta-carotene
• 5 mg lycopene
• 2 mg lutein
• 2 mg alpha-carotene
• beta-cryptoxanthin and zeaxanthin
• All 8 forms of natural vitamin E 300 IU
• Buffered vitamin C 500 mg

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LifePak 40 Antioxidants

• Selenium, Copper, Zinc, Manganese
• Flavonoids
• 6 Catechins (140 mg Tegreen 97)
• Quercetin, naringenin, hesperidin
• 3 Soy isoflavones
• Over 10 grape seed polyphenols
• Alpha-Lipoic Acid 30-50 mg

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Conclusion

• LifePak BioPhotonic Scanner
• The ideal tool to measure LifePaks antioxidant
  effects in your own body

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Future Studies

• Further validation of the BioPhotonic Scanner as
  dietary assessment tool
• to measure fruit vegetable consumption
• to assess overall antioxidant nutrition
• to assess skin and eye health

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Whats Your Score???