Title: Mechanism of Hormone Action
1Mechanism of Hormone Action
2Mechanism of Hormone Action
3Receptor Structure
4Mechanism of Hormone Action
Protein Hormones (cAMP second messenger)
G
Plasma Membrane
Receptor
Protein Kinase A (PKA)
S-ER Steroid Synthesis
Mitochondria
Nucleus
DNA
Protein
R-ER Protein Synthesis
Synthesis
(Enzymes)
5Mechanism of Hormone Action
Protein Hormones (cAMP second messenger)
G
Plasma Membrane
Receptor
Protein Kinase A (PKA)
S-ER Steroid Synthesis
Mitochondria
Nucleus
DNA
Protein
R-ER Protein Synthesis
Synthesis
(Enzymes)
6Mechanism of Hormone Action
Protein Hormones (cAMP second messenger)
G
Plasma Membrane
Receptor
Protein Kinase A (PKA)
S-ER Steroid Synthesis
Mitochondria
Protein
R-ER Protein Synthesis
Synthesis
(Enzymes)
7Mechanism of Hormone Action
Protein Hormones (cAMP second messenger)
G
Plasma Membrane
Receptor
Protein Kinase A (PKA)
S-ER Steroid Synthesis
Mitochondria
Cholesterol
Pregnenolone
Cholesterol
Protein
R-ER Protein Synthesis
Synthesis
(Enzymes)
8Mechanism of Hormone Action
Protein Hormones (cAMP second messenger)
G
Plasma Membrane
Receptor
Protein Kinase A (PKA)
S-ER Steroid Synthesis
Mitochondria
Cholesterol
Pregnenolone
Cholesterol
Protein
R-ER Protein Synthesis
Synthesis
(Enzymes)
9cAMP Second Messenger Hormones
- Anterior Pituitary Hormones
- LH, FSH, Prolactin
- STH, ACTH, TSH
- Placental Hormones
- HCG, eCG
10Protein Hormones (Ca2 Second Messenger)
Plasma Membrane
Receptor
Ca2
Endoplasmic Reticulum
Plasma Membrane
11Protein Hormones (Ca2 Second Messenger)
Plasma Membrane
Receptor
Ca2
Endoplasmic Reticulum
Plasma Membrane
12Protein Hormones (Ca2 Second Messenger)
Plasma Membrane
Receptor
Ca2
Endoplasmic Reticulum
Plasma Membrane
13Protein Hormones (Ca2 Second Messenger)
Plasma Membrane
Receptor
Ca2
Endoplasmic Reticulum
Plasma Membrane
14Protein Hormones (Ca2 Second Messenger)
Plasma Membrane
Receptor
Ca2
Endoplasmic Reticulum
Plasma Membrane
15Calcium Second Messenger Hormones
- GnRH
- triggers release of LH in anterior pituitary
- Oxytocin
- triggers contractions of smooth muscle
- PGF2?
- triggers apoptosis of cell
- inhibition of progesterone synthesis
16Steroid Hormone Action
Cell Membrane
Cytoplasm
Nucleus
DNA
17Steroid Hormone Mechanism
- Estradiol
- Testosterone, Dihydrotestosterone
- Cortisol
18Feedback Loops
Neuro-secretory Cells
Hypothalamus
Releasing Hormones
Polypeptides
Portal Vein
-
Anterior Pituitary
-
Gonadotropins FSH, LH
Proteins
Blood Stream
Gonads
Why only effects on
Receptor on Cell Surface
target organs
Cyclic AMP inside cell
Testosterone
Steroid Hormone Production
Estradiol
Progesterone
Blood Stream
Bound to Protein
19Endocrine Feedback Loops
- Negative
- gonadal steriods
- Testosterone, Progesterone, Estradiol
- Protein hormones
- inhibin
- Positive
- Gonadal steroids
- estradiol