SUPERFICIAL FUNGAL INFECTION DERMATOPHYTOSIS

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SUPERFICIAL FUNGAL INFECTION DERMATOPHYTOSIS

• THREE GENERA KNOWN TO CAUSE DISEASE
• -TRICOPHYTON
• - MICROSPORUM
• - EPIDERMOPHYTON

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EPIDEMIOLOGY

• GEOPHILIC - M.GYPSEUM
  
  M.
  FERRUGINEUM
  - T. TERRESTRE
  
  -
  T.VIOLACEUM
• ZOOPHILIC -
  - M. CANIS CAT, DOGS,SHEEPS
  
  - T. EQUINUM CATS, DOGS,CATTLES
  - T.
  VERRUCOSUM CATS , DOGS, CATTLES,SHEEPS
• ANTHROPOPHILIC -
  -E. FLOCCOSUM
  
  M. AUDOUINII
  
  
  T. MENTAGROPHYTES
  
  T. RUBRUM
  
  T. TONSURANS

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PATHOGENESIS

• FUNGI MUST OVER COME -
  EFFECT OF UV LIGHT
  
  TEMPERATURE VARIATION
  COMPITION
  WITH NORMAL FLORA
  -FUNGISTATIC AGENTS
• FATTY ACIDS,SPHINGOSINES
• - EPIDERMAL GROWTH
• DTH IMMUNE RESPONSE

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TINEA CAPITIS
ECTOTHRIX ENDOTHRIX
YELLOW- GREEN FLUORESCENCE DULL GRAY-GREEN FLUORESCENCE
M.AUDOUINII M.CANIS M.FERRUGINEUM T.SCHOENLEINII
NO FLUORESCENCE NO FLUORESCENCE
M.GYPSEUM T.MENTAGROPHYTES T. RUBRUM T.TONSRANS T. VIOLACEUM

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ORGANISMS ASSOCIATED WITH CLINICAL TYPES OF TINEA
CAPITIS
INFLAMMATORY ZOOPHILIC GEOPHILIC NONINFLAMMATORY ANTHROPOPHLIC ECTOTHRIC BLAK DOT ANTHROPOPHILIC ENDOTHRIX FAVUS
M.AUDOUINII M. CANIS M. GYPSEUM T.MENTAGROPHYTE T.TONSURANS T. VERRUCOSUM M.AUDOUINII M. CANIS M.FERRUGINEUM T.TONSURANS T.TONSURANS T.VIOLACEUM M.GYPSEUM T. SCHOENLEINII T.VIOLACEUM
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TINEA CAPITIS
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TINEA CAPITIS
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TINEA CAPITIS
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BLACK DOT TINEA CAPITIS
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INFLAMMATORY T. CAPITIS
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TINEA BARBAE

• INFAMATORY TYPE- T. MENTAGROPHTE, T.
  VERRUCOSUM
• SUPERFICIAL TYPE - ANTHROPOPHILIC T.
  VIOLACEUM,T.RUBRUM
• CIRCINATE TYPE

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TINEA BARBAE
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TINEA FACEII
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TINEA FACEII
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TINEA BARBE
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TYPICAL TINEA CORPORIS
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TINEA CORPORIS
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INFLAMMATORY T. CORPORIS
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TINEA CORPORIS
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TINEA CORPORIS
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TINEA CORPORIS
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TINEA CORPORIS
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TINEA UNGUIUM
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TINEA UNGUIUM
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TINEA UNGUIUM
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TINEA MANUM
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TINEA MANUM
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TINEA MANUM
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TINEA CRURIS
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TINEA CRURIS
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TINEA CRURIS
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TINEA CRURIS
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TINEA CRURIS
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TINEA PEDIS

• CHRONIC INTERTRIGINOUS TYPE
• CHRONIC HYPERKERATOTIC TYPE
• VESICULOBULLOUS TYPE
• ACUTE ULCERATIVE TYPE

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TINEA PEDIS
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TINEA PEDIS
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TINEA PEDIS
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TINEA PEDIS
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TINEA PEDIS
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KOH MOUNT
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ENDOTHRIX FUNGUS
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ECTOTHRIX FUNGUS100X
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TREATMENT

• SYSTEMIC THERAPY
• TOPICAL THREAPY

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SYSTEMIC ANTIFUNGALS

• ALLYLAMINS
• INHIBITS SQUALENE EPOXIDASE BLOCKING BIOSYNTHESIS
  OF ERGOSTEROL
• FUNGICIDAL
• 3 TO 6 mg/kg OD
• CONTRAINDICATED IN PREGNANCY LACTATION
• TRIAZOLES ITRACONAZOLE, FLUCONAZOLE
• INHIBIT 14 alfa DEMETHYLASE ENZYME IN
  CELL MEMBRANE USEFUL FOR CONVERSION OF SQUALENE
  TO ERGOSTEROL
• .
• IMIDAZOLE KETOCONAZOLE
• GRISEOFULVIN DISRUPS MICROTUBULE MITOTIC
  SPINDLE FORMATON THUS ARREST MITOTIC AT METAPHASE
  STAGE

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TREATMENT
TOPICAL -ALLYLAMINES
TERBINAFINE,NAFTIFINE -BENZYLAMINE
- BUTENAFINE
-IMIDAZOLES CLOTRIMAZOLE, MICONAZOLE,
KETOCONAZOLE -TOLNAFTAE
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THANK YOU.,