BTISNET - BIOTECHNOLOGY INFORMATION SYSTEM NETWORK Bindhu Sreekesh Scientist

1
BTISNET- BIOTECHNOLOGY INFORMATION SYSTEM
NETWORKBindhu SreekeshScientist
DNICCELLDepartment of Biotechnology, New Delhi
2
What is Bioinformatics

• Bioinformatics is a scientific discipline
  that compasses all aspects of biological
  information acquisition, processing, storage,
  distribution, analysis and interpretation.
• It is a multi disciplinary subject which
  combines the tools of Biology, Chemistry,
  Mathematics, Statistics and Computer Science to
  understand Life its processes.

3
Bioinformatics in India

• 1983
• Formation of Task Group on Bioinformatics by Dr.
  S. Ramachandran
• 1986Department of Biotechnology established
• 1987
• Biotechnology Information System Network
  (BTISnet)
• 1st grant of Rs.13.38 crores by DBT towards
  setting up of National Infrastructural Facility
  on Bioinformatics

4

• 1988
• Establishment of the first 9 DICs in India
• 1989 onwards.
• Establishment of DIC sub-centers

5
Current Status

• DICs 10
• Sub-DICs 48
• Center of Excellence 6

6
WHY BTISNET?

• Enormous growth of Biological data size
  information
• Recognized the importance of IT for advanced
  research
• Transfer and exchange of information, scientific
  knowledge, technology packages

7
OBJECTIVES

• To provide a national bioinformatics network
  designed to bridge the inter disciplinary gaps on
  biotechnology information and establish link
  among scientists in organizations involved in RD
  and manufacturing activities in the country.
• To build up information resources, prepare
  databases on biotechnology and to develop
  relevant information handling tools and
  techniques.
• To continuously assess information requirements,
  organize creation of necessary infrastructure and
  to provide information and computer support
  services to the national community of users
  working in biotechnology and allied areas.  
•  

8
OBJECTIVES

• To coordinate efforts to access Biotechnology
  information world wide including establishing
  linkages with some of the international resources
  of Biotechnology information (e.g. Databanks on
  genetic materials, published literature, patents,
  and other information of scientific and
  commercial value.
• Perform research into advanced methods of
  computer based information processing for
  analyzing the structure and function of
  biologically important molecules.  

9

• To evolve and implement programmes on education
  of users and training of information scientists
  responsible for handling of biotechnology
  information and its applications to biotechnology
  research and development.
• To promote international collaboration towards
  exchange of scientific information in
  biotechnology through the development of
  appropriate network arrangements.

10
HOW IT IS STRUCTURED
11
BTISNET
DICs
COEs
SDICs
12
(No Transcript)
13
CENTRES OF EXCELLENCE (CoEs)

• To undertake advanced research in frontier
  areas in Bioinformatics and computational biology
  and act as national hubs in bioinformatics for
  creating a platform for biotechnology
  development, technology transfer and
  commercialization.

14
1. Bose Institute 2. Indian Institute of
Science 3. Jawaharlal Nehru University 4. Madurai
Kamaraj University 5. University of Pune
15
RESEARCH ACTIVITIES PROPOSED TO BE UNDERTAKEN BY
THE COEs       

• Bose Institute, Calcutta
• Modelling of protein structures
• Molecular interactions and docking
• Drug design
• Chromosomal dynamics
• Stress biology of plants
• Functional genomics
• Host-pathogen interaction

16

• Indian Institute of Science, Bangalore
• Analysis of protein structures, motifs and
  recognition
• Peptide design
• Protein folding studies
• Structural biology of lectins, xylanase,
  phycocyanins, phospholipase etc
• Structural genomics
• Annotation and functional analysis of genomes
• Microarray informatics

17

• Jawaharlal Nehru University, New Delhi
• Building gene models
• Improved algorithms for first and last exon
  predictions
• Genome evolution
• Virtual screening and drug design
• Prediction of ligand binding site of proteins
• University of Pune, Pune
• Comparative and structural genomics
• Comparative structural genomics
• Metabolic pathway engineering
• Proteomics

18

•  (v) Madurai Kamraj University, Madurai
• Genomics, proteomics and structural
  bioinformatics of selected regulatory systems in
  Streptomyces, Salmonella etc
• Validation and annotation of databases of
  selected organisms
• Computational and experimental analysis of
  selected systems    

19
Priority Areas of the proposed Centres
Institution Priority Area
Bose Institute Molecular Modeling Genetic Engineering
Indian Institute of Science Structural Biology Bioinformatics
Jawaharlal Nehru University Computational Genomics
Madurai Kamraj University Genetic Engineering Structural Bioinformatics
University of Pune Computational Biology Genomics

•    

20
Sub DICs upgraded to DICs

• Anna University
• Kerala Agricultural University
• M.S. University, Baroda
• University of Calcutta
• Pondicherry University

21
NEW BIOINFORMATICS CENTRES

• Central Agricultural Research Institute, Port
  Blair
• College of Engineering, Raipur
• T.M.bahalpur University, Bahalpur
• Birla Institute of Technology, Ranchi

22

• DISTRIBUTED INFORMATION CENTRES (DICs)
• Anna University
• CCMB
• IARI
• IMT
• KAU
• MSU, Baroda
• NBRC
• NII
• Pondicherry University
• University of Calcutta

23

• DISTRIBUTED INFORMATION SUB CENTRES (SDICs)
• ACTREC
• Aligarh Muslim University
• AIIMS
• AAU
• BHU
• Barkatullah University
• Banasthali Vidyapith
• Bharathidasan University
• Birla Institute of Scientific Research
• Birla Institute of Technology
• Biotech Consortium Indian Ltd.
• Biotech Park in Biotechnology City
• CARI
• HPU
• NEHU
• CDRI
• IICB

24

• DISTRIBUTED INFORMATION SUB CENTRES (SDICs)
  (Contd..)
• PAU
• CIFA
• IISR
• RGCB
• CIMAP
• IIT, Delhi
• RRL, Jammu
• CPCRI
• IIT, Kharagpur
• SCST for Sikkim
• CSRTI
• IVRI
• T. M. Bhagalpur University
• CSKKV
• Institute of Life Sciences
• TNAU
• Dr. Y.S. Parmar Univeristy

25
DISTRIBUTED INFORMATION SUB CENTRES (SDICs)
(Contd..)

1. TNVASU
2. DAVV
3. MSSRF
4. TBGRI
5. Engineering College
6. NBRI
7. University of Agricultural Sc.
8. G. B. PantNagar Univer.
9. NDRI
10. University of Delhi
11. GNDU
12. NIO
13. University of Kashmir

26
Educational Activities of India in Bioinformatics

• Short-Term Training
• Nationwide trainings and workshops
• Presently around 100 organised per year in
  different areas
• More than 17000 trained so far
• Long-Term Training
• Advanced Diploma Courses in five Universities
• M.Sc., M.Tech., Ph.D. courses in Bioinformatics

27
1. Advanced Diploma Courses

1. MKU, Madurai
2. University of Pune
3. University of Calcutta
4. JNU, New Delhi
5. Pondichery University

2. Post-graduate Courses (M.Sc, M.Tech, Ph.D)

• JNU, New Delhi
• University of Pune
• Bose Institute
• Anna University
• National Brain Research Centre

28
3. Traineeship/ Studentship4. Short-term
Training and Workshop Programmes
29
Developmental Activities

• Database development
• Software Development
• R D Activities in Bioinformatics

30
BIOGRID INDIA

• ENOURMOUS GROWTH OF INFORMATION
• Dissemination of Biotechnology information to
  researchers in the country
• Human Resource Development
• RD activities in Bioinformatics
• Database sharing
• Course material sharing

31
BIOGRID INDIA
Internet
MK Univ., Madurai
IGIB, Delhi
South Campus, DU, Delhi
Service Providers VPN Network
IMT, Chandigarh
Deptt. Of Biotecdhnology, Delhi
Univ. of Pune
IIT, , Delhi
CDFD, Hyderabad
Router
NBRC, Gurgaon
NII, Delhi
IISc, Bangalore
JNU, Delhi
22nd September, 2005
23
32
INSTITUTIONS IN BIOGRID INDIA

1. JNU Bioinformatics Center, JNU
2. University of Delhi South Campus.
3. Madurai Kamraj University, Madurai.
4. Indian Institute of Science
5. National Institute of Immunology.
6. Institute of Microbial Technology
7. Department of Biotechnology
8. University of Pune
9. Institute of Genomics Integrative Biology,
   Delhi University Campus, Mall Road near Jubilee
   Hall Delhi.
10. National Brain Research Centre
11. Centre for DNA Fingerprinting and Diagnostics,
    Hyderabad.
12. Indian Institute of Technology, New Delhi.

33
INTEGRATION OF BIOTECHNOLOGY DATABASES ON BTISNET
BioGrid Nodes/ Server High Speed Network
Agricultural Biotechnology
Aquaculture Marine Biotechnology
Animal Biotechnology
Medicinal or Aromatic Plants
USERS
BIOTECHNOLOGY PORTAL
Biodiversity Databases
Molecular Biology
Medical Biotechnology
Mirror Sites on Major Databases
BTISNet Software package
34
Achievements

• Emphasis on infrastructure creation and human
  resource development
• Biotechnology in India has greatly benefited from
  the capacity building in Bioinformatics
• Dedicated virtual private network connecting the
  major centres sharing of data as well as
  computing resources
• Biogrid India (VPN)
• Centres of Excellence in Bioinformatics

35
DBT INFRASTRUCTURE
Local Area Network LAN Website
http//www.dbtindia.nic.in
http//www.btisnet.nic.in List servers
btis.dbt_at_lsmgr.nic.in noticeboard.dbt_at_lsmgr.
nic.in Library FTS NAS
36
Future plans

• Extension of high speed and large bandwidth
  network connectivity to other BTISnet centers and
  DBT institutions.
• Augmentation of infrastructure at the BTISnet
  centers to cope up with enhanced IT applications
  in Biotechnology.
• Mirroring of more biological databases, useful to
  the researchers.

37

• Cataloging of BTISnet products to promote sharing
  of information resources over the network.
• Support to RD projects in Bioinformatics as well
  as projects aimed at creating bioinformatics
  resources on net.
• Publication of Bioinformatics textbooks and
  monographs.
• Setting up of a Digital/Electronic Library for
  effective delivery of information to the end
  users.
• Establishing a video conferencing facility

38
THANK YOU