Title: Outline of talk
1Golden Hour Lung Protective Strategy from Birth
- Proper pressures in the DR
- Proper FiO2 in the DR (blended)
- Surfactant in the DR
- CPAP in the DR
- Consistent CPAP in the NICU
- Reduced SIMV in the NICU
2(No Transcript)
3good judgement
informed jugement
4Neo-Puff in the DR
- manual ventilation of
- babies lt30 weeks gest.
- Used for all transport
- ventilation for all babies
5Neo-Puff Infant Resuscitator
- easy to use,
- manually operated
- gas-powered.
6Controlled and Precise Peak Inspiratory Pressure
(PIP) The Neopuff Infant Resuscitator will
inflate the babys lungs provide optimum
oxygenation by delivering consistent PIP with
each breath, limiting the risks associated with
under or over inflation at uncontrolled
pressures. Consistent and Precise Positive End
Expiratory Pressure (PEEP) The Neopuff Infant
Resuscitator maintains Functional Residual
Capacity (FRC) by providing a consistent PEEP
throughout the resuscitation process.
7 The desired PIP is set by turning the
inspiratory pressure control. The desired
PEEP is set by adjusting the T-piece aperture.
8(No Transcript)
9(No Transcript)
10Pressure/Volume
11Over Weaning damages too
12Ventilator-Associated Lung Injury
- Barotrauma (air leak)
- Oxygen toxicity
- Ventilator associated pneumonia
- Over-distention
- De-recruitment
13Biochemical Injury Biophysical
Injury
- Shear
- Overdistention
- Cyclic stretch
- Inc. intrathoracic pressure
Cytokines, prostanoids, Leukotrienes, reactive
oxygen species, protease
- Inc alveolar cap permeability
- Dec cardiac output
- Dec organ perfusion
- Tissue injury secondary to
- Inflamatory mediators/cells
- Impaired O2 delivery
- bacteremia
Distal Organs
neutrophil
Slutsky and Tremblay Am J Respir Crit Care Med
1998 157 1721-1725
Death
MOSF
14normal lungs
20 min of 45 cm H2O
5 min of 45 cm H2O
Dreyfuss, Am J Respir Crit Care Med
1998157294-323
1514/0 45/10
45/0
Webb and Tierney, Am Rev Respir Dis 1974
110556-565
16(No Transcript)
17esophagealintubation
18- Pulmonary
- Interstitial
- Emphesema
- to Pneumo-
19(No Transcript)
20Assessment
- Chest x-ray AP
- 8 rib conventional
- 9-10 rib Hi-Fi
- Rise fall of chest (slight per NRP)
- Listen to breath sounds
- Vt 5-7 ml/kg (3-5 spont.)
- follow ABGs
21Pressure Wave
- To Increase Mean Airway Pressure
- 1. Increase flow
- 2. Increase peak pressure
- 3. Lengthen inspiratory time
- 4. Increase PEEP
- 5. Increase Rate
22(No Transcript)
23TYPES OF MECHANICAL VENTILATION
- negative pressure ventilation
- positive pressure ventilation
- high-frequency ventilation
- non-invasive positive pressure ventilation
24Body Box
25Outline
- Respiratory mechanics and gas exchange
- Factors affecting oxygenation and carbon dioxide
elimination during mechanical ventilation - Blood gas analysis
- Ventilatory management basics and specifics
- High frequency ventilation the basics
26Overview
- Mechanical ventilation is an integral part of
neonatal intensive care, and has led to increased
survival of neonates over the last 3 decades - Advances in knowledge of neonatal respiratory
physiology have led to optimization of techniques
and strategies - Conventional mechanical ventilation (CMV) is most
often used, despite the advent of HFV and SIMV
27Overview
- Respiratory failure in neonates has significant
morbidity and mortality (although less than in
the past) - Optimal ventilatory management will reduce the
risk of chronic lung disease - Optimal ventilatory management should be
individualized and be based upon the
pathophysiology and certain basic concepts of
mechanical ventilation
28Concepts
- Goal of mechanical ventilation to improve gas
exchange and to sustain life without inducing
lung injury - Factors that should influence ventilator
adjustment decisions - Pulmonary mechanics
- Gas exchange
- Control of breathing
- Lung injury
29Pulmonary mechanics
- Compliance
- Property of distensibility of the lungs and chest
wall - Change in volume per unit change in pressure
- C D Volume
- D Pressure
- Neonatal lung
- Normal 0.003-0.006 L/cm H2O
- with RDS 0.0005-0.001 L/cm H2O
30Pulmonary mechanics
- Resistance
- inherent capacity of the air conducting system
(airways and ETT) and tissues to resist airflow - Change in pressure per unit change in flow
- R D Pressure
- D Flow
- Total cross-sectional area of airways
- Resistance Length of the airways
- Flow rate
- Density and viscosity of gas
31Pulmonary mechanics
- Location of airway resistance
-
- 0 5 10 15 20
- Distal airways contribute less to resistance due
to increased total cross-sectional area - Small ETT and high flow rates can increase
resistance markedly
Resistance
Distal --gt
Airway Generation
32Pulmonary mechanics
- Laminar flow (Distal airways)
- Driving pressure proportional to flow
- R 8 n l (n viscosity l length r
radius) - p r4
- Turbulent flow (Proximal airways)
- Driving pressure proportional to square of flow
- Reynolds number (Re) 2 r V d (d density)
- n
33Pulmonary mechanics
- A pressure gradient between the upper airway and
alveoli is necessary for gas flow during
inspiration and expiration - The pressure gradient is required to overcome the
elasticity, resistance, and inertance of the
respiratory system - Equation of motion P 1 V R V I V
- C
ElasticityResistanceInertance
34Pulmonary mechanics
- Time constant
- The time taken for the airway pressure (and
volume) changes to equilibrate throughout the
lung is proportional to the compliance and
resistance of the respiratory system - Time constant Compliance x Resistance
35Pulmonary mechanics
- change in pressure in relation to time
- Almost full equilibration 3-5 time constants
99
98
95
100
86
80
63
Change in pressure ()
60
40
20
0
1 2 3 4 5 Time constants
36Pulmonary mechanics
- Healthy term neonate
- C 0.004 L/cm H2O R 30 cm H2O/L/sec
- T 0.004 x 30 0.12 sec
- Time constants Time (sec) equilibration
- 1 0.12 63
- 2 0.24 86
- 3 0.36 95
- 5 0.60 99
- RDS Shorter time constant
37Pulmonary mechanics
- Application of the concept of time constant
- Short TI decreased tidal volume delivery
- Inadequate TE Gas trapping ( FRC,
inadvertent PEEP) - Heterogeneous lung disease (BPD) different
regions of the lung have different time
constants tendency for atelectasis and
hyperexpansion to co-exist
38Gas exchange
- Total minute ventilation tidal vol x freq
- VE VT x f
- Alveolar ventilation (VA) Useful (fresh gas)
portion of minute ventilation that reaches gas
exchange units excludes dead space (VD) - VA (VT-VD) x f
- Alveolar ventilation equation
- VA (L/min) VCO2 (ml/min) x 0.863 (BTPS
PACO2 (mm Hg)
corr.) -
39Gas exchange
- Alveolar gas equation
- If R1, each molecule of O2 removed from alveoli
is replaced by one molecule of CO2 - PAO2 PIO2 - PACO2
- Average normal value for R 0.8
- PAO2 FIO2 x (PB-PH2O) - PACO2x FIO2 1- FIO2
- R
- PaCO2 effective PACO2
- True PACO2 PETCO2
40Gas exchange
- Ventilation-Perfusion matching
- matching of gas flow and blood flow required for
successful gas exchange - VA Alveolar ventilation
- Q Pulmonary blood flow (Fick method O2)
- 0.863 x R x (CaO2 - CVO2)
- PACO2
- V/Q mismatching usually relevant to effect on
alveolar-arterial PO2 difference (A-a)DPO2
41Gas exchange
0.2
v
0.5
1.0
V/Q 0
1.5
PCO2
Ideal V/Q 0.84
0 20 40 60
I
8
V/Q
40 60 80 100 120 140 160
P O2 (mm Hg)
42Gas exchange
- Causes of hypoxemia
- V/Q mismatch
- Right to left shunt (venous admixture)
- Hypoventilation (e.g. in apnea)
- Diffusion abnormalities
- Causes of hypercapnia
- Hypoventilation
- Severe V/Q mismatch
43Gas exchange
- Factors involved in gas exchange during
mechanical ventilation - Oxygenation
- Carbon dioxide elimination
- Gas transport mechanisms
- Patient - ventilator interactions
44Gas exchange
- Factors affecting oxygenation
- Mean airway pressure (MAP) affects V/Q
matching. MAP is the average airway pressure
during respiratory cycle - MAP K (PIP-PEEP) TI / (TITE) PEEP
- Oxygen concentration of inspired gas (FIO2)
45Gas exchange
- MAP increases with increasing PIP, PEEP, TI to TE
ratio, rate, and flow
PIP
Pressure
Flow
Rate
TI
PIP
PEEP
PEEP
Time
TI
TE
46Gas exchange
- Relation of MAP to PaO2 not linear is like an
inverted U - Low MAP
- Atelectasis--gt very low PaO2
- High MAP
- hyperinflation--gt V/Q mismatch intrapulmonary
shunt, hypoventilation due to distended alveoli - decreased cardiac output --gt decreased oxygen
transport despite adequate PaO2
47Gas exchange
- For the same change in MAP, changes in PIP and
PEEP improve oxygenation more than changes in IE
ratio - Reversed IE ratios increase risk of air-trapping
- PEEP levels higher than 6 cm H2O may not improve
oxygenation in neonates - Attainment of optimal MAP may allow weaning of
FIO2 - Atelectasis may lead to sudden increase in
required FIO2
48Gas exchange
- Carbon dioxide elimination
- Proportional to alveolar ventilation (VA) which
depends on tidal volume (VT) and frequency (rate)
- VT changes more effective (but more barotrauma)
dead space constant, so proportion of VT that is
alveolar ventilation increases to a greater
degree with increases in VT - VT 4 --gt 6cc/kg (50 ) with dead space of 2
cc/kg increases VA from 2 (4-2) to 4 (6-2)
cc/kg/breath (100 )
49Gas exchange
- Clinical estimation of optimal TI and TE
Short TI Optimal TI Long TI
Inadeq VT Short insp. plateau Long plateau
Chest Wall Motion
Time
Short TE Optimal TE
Long TE
Air trapping Short exp. plateau Long exp.
plateau
Chest Wall Motion
50Gas exchange
- Synchrony vs. Asynchrony fighting
- Synchrony augments ventilation, improves CO2
elimination, decreases hypoxic episodes - Asynchrony leads to poor tidal volume delivery,
and impairs gas exchange - Active exhalation (exhalation during ventilator
breath) increases risk of hypoxic episodes
51Blood gas analysis
- Arterial blood gas analysis the gold standard
- Interpretation
- pH Is it normal, acidotic, or alkalotic?
- PCO2 Is it normal, (respiratory acidosis), or
(respiratory alkalosis)? - HCO3 Is it normal, (metabolic acidosis), or
(metabolic alkalosis)? - Simple disorder or mixed? Compensated or not?
- PO2 Normal, hypoxia, or hyperoxia?
52Blood gas analysis
- Normal values (1 hr age, not ventilated)
- Preterm pH 7.28-7.32, PCO2 35-45, PO2 50-80
- Term pH 7.30-7.35, PCO2 35-45, PO2 80-95
- Target values
- RDS pH gt 7.25, PCO2 45-55, PO2 50-70
- BPD pH gt 7.25, PCO2 45-70, PO2 60-80
- PPHN pH 7.50-7.60, PCO2 25-40, PO2 80-120
- Remember! O2 content determined mostly by SpO2
and Hb.
53Blood gas analysis
- Common errors
- Infrequent ventilator adjustments made only when
ABG (q4/q6) is obtained. In acute phase of RDS or
PPHN, adjustments should be made with chest rise,
SpO2, TcPO2/PCO2 trends - Room air contamination PCO2, PO2(if lt150
torr ). Amount in butterfly set sufficient ! - Liquid heparin /saline contamination pH same,
but lower PCO2 (mimics compensated metabolic
acidosis)
54Ventilatory management
- Indications
- Clinical Absolute Apnea (intractable), gasping,
cyanosis not responsive to O2 by hood - Relative Severe tachypnea / retractions
- Laboratory (while on CPAP or FiO2 gt 0.7)
- pH lt 7.25 with PCO2 gt 60
- (or) PO2 lt 45- 50 and / or SpO2 lt 85
- Other Surgical procedures, compromised airway
55Ventilator settings
- PIP
- affects MAP (PO2) and VT (PCO2)
- PIP required depends largely on compliance of
respiratory system - Clinical gentle rise of chest with breath,
similar to spontaneous breath - Minimum effective PIP to be used. No relation to
weight or airway resistance - Neonate with RDS 15-30 cm H2O. Start low and
increase.
56Ventilator settings
- PEEP
- affects MAP (PO2), affects VT (PCO2) depending on
position on P-V curve - older infants (e.g. BPD) tolerate higher levels
of PEEP (6-8 cm H2O) better - RDS minimum 2-3, maximum 6 cm H2O.
Volume
PEEP PIP
Pressure
57Ventilator settings
- Rate
- affects minute ventilation (PCO2)
- In general, rate ---gt PCO2
- Rate changes alone do not alter MAP (with
constant IE ratio) or change PO2 , unless PVR
changes with changes in pH - However, if rate --gt TE lt 3TC --gt gas
trapping--gt decreased VT--gt PCO2 - Minute ventilation plateaus, then falls with
rate
58Ventilator settings
- TI and TE
- Need to be 3-5 TC for complete inspiration and
expiration (Note TC exp TC insp) - Usual ranges TI sec TE sec
- RDS 0.2-0.45 0.4-0.6
- BPD 0.4-0.8 0.5-1.5
- PPHN 0.3-0.8 0.5-1.0
- Chest wall motion / VT may be useful in
determining optimal TI and TE
59Ventilator settings
- I E Ratio
- When corrected for the same MAP, changes in IE
ratio do not affect gas exchange as much as
changes in PIP or PEEP - Changes in TI or TE do not change VT or PCO2
unless they are too short (lt 3 TC) - Reversed IE ratio No change in mortality or
morbidity noted in studies. Not often used. May
improve V/Q matching and PO2 at risk of
venous return and gas trapping
60Ventilator settings
- FiO2
- affects oxygenation directly
- with FiO2 lt0.6-0.7, risk of oxygen toxicity less
than risk of barotrauma - to improve oxygenation, increase FiO2 to 0.7
before increasing MAP - during weaning, once PIP is low enough, reduce
FiO2 from 0.7 to 0.4. Maintenance of adequate MAP
and V/Q matching may permit a reduction in FiO2
61Ventilator settings
- Flow
- affects pressure waveform
- minimal effect on gas exchange as long as
sufficient flow used - increased flow--gt turbulence
- higher flow required if TI short, to maintain TV
- flow of 8-10 lpm usually sufficient
- change of flow may affect delivery of NO or
anesthesia gases
62Ventilatory management
- RDS
- Pathology decreased compliance, FRC
- Once diagnosis established, and if PO2lt50 on 40
oxygen CPAP (or) early intubation and
surfactant. (Prophylactic CPAP for ELBW not
useful) - Ventilation if FiO2 gt 0.7 required on CPAP
- Surfactant q 6 hrs if intubated and FiO2 gt
0.3-0.4 (Survanta / Infasurf / Curosurf better
than Exosurf). Usually 1-2, rarely 4 doses
required.
63Ventilatory management
- RDS (continued)
- Use lowest PIP required
- moderate PEEP (4-5 cm H2O)
- permissive hypercarbia (PaCO2 45-55 mmHg instead
of 35-45 is safe, and need for ventilation in
first 4 days) - limited use of paralysis, aggressive weaning
- chest PT not useful, maybe dangerous in acute
phase (increases IVH)
64Ventilatory management
- Chronic lung disease / BPD
- usually heterogeneous lung disease - different
areas of lung with different time constants - increased resistance, frequent exacerbations
- higher PEEP often helpful (4-7 cm H2O)
- longer TI and TE, with low rates
- hypercarbia and compensated respiratory acidosis
often tolerated to avoid increased lung injury
65Ventilatory management
- PPHN
- ventilator management controversial
- FiO2 adjusted to maintain PaO2 80-100 to minimize
hypoxia-mediated pulmonary vasoconstriction - ventilatory rates and pressures adjusted to
maintain mild alkalosis (pH 7.5-7.6), usually
combined with bicarbonate infusion - avoid low PaCO2 (lt20 mm Hg) to prevent cerebral
vasoconstriction
66Volume Guarantee
67Pressure Support VentilationWorking Principle of
Breath Termination
Erin Browne
68Flow SensorMeasurement Principle
T 400C no gas flow with gas flow
- Two tiny platinum wires are heated to 400C
- Gas flow cools the wire down
- From the amount of cooling the amount of gas
flowing can be calculated
69Endotracheal Tube Leak
70Lung Function MonitoringClinical Applications
- Identification of Lung Overdistention
- Prediction of successful extubation
- Prediction of risk of BPD development
- Response to Surfactant or Brochodilators
- Teaching tool
- Titration of optimal PEEP
- Trend in development of disease
- Check of compliance during HFV
- recognition of recovery from suctioning
71(No Transcript)
72(No Transcript)
73O S C I L L A T O R
74(No Transcript)
75High frequency ventilation
- Techniques
- HFPPV HFJV HFFI HFOV
- VT gtdead sp gt or lt ds gt or ltds
ltds - Exp passive passive passive
active - Wave- variable triangular triangular
sine wave - form
- Entrai- none possible none none
- ment
- Freq. 60-150 60-600 300-900
300-3000 -
(/min)
76High frequency ventilation
- HFPPV
- conventional ventilators with low-compliance
tubing - ventilatory rates of 60-150/min
- not very effective minute ventilation decreases
with high frequencies - ventilator and circuit design are not optimal for
use at frequencies
77High frequency ventilation
- HFJV (e.g. Bunnell Life Pulse HFJV)
- adequate gas exchange with lower MAP
- Servo pressure reflects volume ventilated
- increases with improving compliance or
resistance or by peri-ET leaks - decreased by worsening compliance, resistance,
obstruction, or pneumothorax - Larger babies 300 bpm smaller ones 500 bpm
78High frequency ventilation
- HFJV (contd.)
- MAP controls PaO2, DP (and frequency) control
PaCO2. (MAP controls lung volume. PaO2 will not
respond to increased MAP if FRC normal) - smaller TV (DP) with higher PEEP better than
larger TV with lower PEEP (--gt hypoxia with
hypocarbia) - Optimal PEEP no drop in SpO2 when CMV off
- Parallel conventional ventilation recruits
alveoli (use low rate 1-3 bpm 0-1 bpm if air
leak)
79High frequency ventilation
- HFOV (e.g. Sensormedics 3100A)
- Generally used at more MAP than CMV optimal MAP
difficult to determine as CXR rib space
counting not very accurate - Frequency 5-10 Hz better for CO2 elimination
10-15 Hz better for improving oxygenation - maybe useful in airleak syndromes
- maybe useful in PPHN may decrease need for ECMO
esp. if combined with NO
80High frequency ventilation
- HFFI (e.g. Infant Star with HFFI module)
- active expiration in Infant Star model makes
operation more like HFOV - clinical studies have not shown it to be superior
to conventional ventilation - more convenient single ventilator for CMV and
HFV makes initiation and weaning easier
81High frequency ventilation
- Uses of HFOV/ HFJV/ HFFI
- rescue for severe RDS
- air leak syndromes (pneumothorax, PIE)
- PPHN
- Primary use controversial risk of hypocarbia
(--gtPVL) higher, and reduction of BPD or airleaks
seen in some, but not all, studies.
82Summary
- The practice of the art of mechanical
ventilation lies in the application of the
underlying science and physiologic concepts to
the specific clinical situation - An individualized flexible approach aimed at
maintaining adequate gas exchange with the
minimum of ventilatory support, both in magnitude
and duration, should optimize the possible outcome
83Combining IMV and HFV
84(No Transcript)
85(No Transcript)
86(No Transcript)
87(No Transcript)
88(No Transcript)