Bioinorganic Chemistry of Other Metals

1
Bioinorganic Chemistry of Other Metals

• Co, Mo, Mn
• Heavy Metals Pt, Hg, Pb, As, Cd

2
Heavy Metal Toxicity

• Membrane Transport
• Metal Binding and Storage
• Chemical Transformation

3
Mechanisms of Metal Toxicity

• Blocking the essential biological functional
  groups of biomolecules
• Displacing the essential metal ion in
  biomolecules
• Modifying the active conformation of biomolecules

4
Metal Complexes as Probes of Structure and
Reactivity

• Isomorphous replacement ???????
• 1. size,coordination number and geometry
• 2. kinetic and thermodynamic binding
  parameters
• 3. appropriate physico-chemical property of
  the
• probe ion that may be readily monitored
• K and Tl Mg 2, Mn 2, and Ni 2 Ca 2
  and Mn 2 Zn 2 and Co 2

5
Chapter 4 Biotransformation of Nonmetallic
Inorganic Compounds

• Bioinorganic Chemistry of Oxygen
• Nitrogen Compounds
• Sulfur Compounds
• Phosphorus Compounds

6
Bioinorganic Chemistry of Oxygen
Oxido-Reductase

• Oxidase SH2 O2 A H2O2
• Peroxidase SH2 H2O2 S H2O
• Catalase 2 H2O2 H2O O2
• Superoxide dismutase 2O2 2H H2O2 O2
• Oxygense
• Dioixygenase SH2 O2 SOOH2
• Monooxygenase R3C O2 AH2 R3C-OH A
  H2O

7
Nitrogen Compounds The
Nitrogen Cycle organic nitrogen
compounds NH3
N2 N2O NO2-
NO3
8
Sulfur Compounds SO42- SO32-
HS-R, R-S-S-R
H2S
9
Phosphorus Compounds H3PO4 H3PO3
H3PO2 PH3
10
Chapter 5 The Frontier of Bioinorganic Chemistry

• Small molecule activation by metalloproteins
• Biomineralisation
• Mixed-valence metal clusters in biology
• Metals in medicine

11
ltCurrent Opinion in Chemical Biologygt
Bio-inorganic Chemistry
Vol 4 No 2 April 2000

• Metal ions special delivery
• Channels and pumps
• Metallic signals through folding
• Biomineralization
• Metal clusters
• Metals and neuroscience
• Electron transfer
• Metaloenzymes, including models