Be a Champion

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• Be a Champion
• 2005 Workshop

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Richard Higbee Vice President Global Marketing
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Our Promise

• We promise you will leave with . . .
• A Clear Understanding of the Pharmanex Vision and
  Strategy
• A Conviction That Pharmanex Products Change Lives
• Key Message Points That Will Help You Build Your
  Business

Business Take-aways
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The Pharmanex Strategy

• Our strategy is to leverage science in order to
  create the most innovative sponsoring products in
  the dietary supplement and functional foods
  industry.

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Michael Chang, Ph.D.
Joseph Chang, Ph.D.
Chief Scientific Advisor, Pharmanex Fellow
President of Pharmanex
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First Pharmanex office
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Homestead
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USA Today Circa 1997
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Pharmanex Pharma-Next

• Next Generation Pharmaceutical

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I See a Future
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I See a Future

• You as ambassadors of good health

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I See a Future

• You as ambassadors of good health
• The world knowing their antioxidant score

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Extraordinary Science

• Personalized
• Revolutionized
• Simplified

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Extraordinary Science

• Personalized
• Revolutionized
• Simplified

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Body Fat and Antioxidant Protection
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• Breaking News
• Landmark Scanner Study

Skin Carotenoid Score Antioxidant Protection
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Extraordinary Science

• Personalized
• Revolutionized
• Simplified

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Lighter Smaller Faster
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Global Rollout

• China, Europe, US Markets
• February 2006
• Other markets soon after!
• Learn more in your regional meeting

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I See a Future

• A Winning Strategy

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I See a Future

• A Winning Strategy
• Simplicity

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Extraordinary Science

• Personalized
• Revolutionized
• Simplified

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Now is the time to Scan the World!
10 Million People by 2007
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Michaels Business Take-aways

• Original Pharmanex Slogan
• Pharmaceutical companies improve health with
  medicines, Pharmanex improves health without
  medicine
• Pharmanex is derived from Pharma-next or Next
  Generation Pharmaceutical

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Joes Business Take-aways

• 10M by 2007
• The scanner is the gold standard for overall
  antioxidant protection
• We must SCAN THE WORLD

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Major Accomplishments

• Global Product Rollout
• BioPhotonic Scanner
• TRA
• Marine Omega
• Estera
• Stevie Award NBJ Award
• Product Certifications
• China Manufacturing
• Scanner Oxidative Stress Study

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Science Tradition
Mark R. Bartlett Ph.D. Sr. Director Pharmanex
New Product Development
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Fruit Phytonutrients

• At least 1,000 phytochemicals identified with
  cell protective effects
• Very few (25) studied
• Fruits and vegetables more than meets the eye
• We dont eat enough fruits and vegetables

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3 years agoPharmanex began Searching the
World for Superfruits

• RD evaluated hundreds of fruits for
• Extraordinary antioxidant power (Scanner)
• Extraordinary nutritional contents
• Quality of scientific efficacy data
• Impeccable safety data
• History of traditional folklore usage

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Why the long search and Why the long list?
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Free Radicals Sources

• Environmental pollution (smog, ozone, NO2)
• Radiation exposure
• sunlight (UV-light), X-rays, etc.
• Smoking
• 10,000,000,000,000,000 free radicals/cigarette!

• Eating and Breathing metabolism in your
  mitochondria

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Mitochondria The Energy Furnaces of the body
Free Radicals
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Pharmanex Research Centerswere involved

• Provo RD Center
• Shanghai RD Center
• Beijing RD Center

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years of searching

• Almost all failed Selection criteria
• All but Four (g3) very special fruits

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Gâc - Fruit From Heaven

• Indigenous to Southern Asia
• Bangladesh, Burma, Cambodia, China, India, Japan,
  Laos, Malaysia, Philippines, Thailand, and
  Vietnam
• Traditionally used internally and externally
• Topical wound healing
• Internally eye health, and to promote growth in
  children

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• Antioxidants in Gâc Pulp

• Extraordinarily rich in antioxidants, esp.
  lycopene, beta-carotene, vitamin E
• Unique fatty acids ? Lipocarotenes

Pulp (aril)
Fruit flesh (mesocarp)
Seeds
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Pharmanex Research Centers
3 Years of Searching and RD
3 1 Superfruits

• Gâc fruit (Chinese Bitter Cucumber)
• Chinese Lycium (Wolfberry)
• Cili fruit
• Siberian Pineapple (Seabuckthorn)

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• Gac Fruit Lycopene Content

70 x more than tomatoes!
mcg/g wet weight Ishida et al., J Agric Food Chem
52274, 2004
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• Gac Fruit Beta-Carotene Content

10 x more than carrots!
mcg/g wet weight Ishida et al., J Agric Food Chem
52274, 2004
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Gâc Fights Vitamin A Deficiency

• a Leading cause of blindness in the world
• In So. Asia, Gâc discovered as potent indigenous
  source of highly bioactive provitamin A
  (b-carotene)
• 10 years of research by Dr. Le Vuong, Univ. of
  California, Davis, Nutrition Department

Vuong LT et al., Am J Clin Nutr 200275872-879.
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• Zeaxanthin in Chinese Lycium Fruit

40 x more than yellow corn!
mcg/g wet weight
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• Vitamin C in Cili Fruit

60 x more than oranges!
mg/100g wet weight
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Lipocarotenes

• Natures unique nutrient delivery system in
• Gâc
• contain fatty acids (unique among fruits)
• with carotenoids vitamin E pre-dissolved
• Gâc carotenes 40 improved uptake

compared to beta-carotene powder. Vuong LT et
al., Am J Clin Nutr 200275872-879.
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Vulnerable to Oxidation
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Internal Antioxidants
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Proprietary

• Patent pending, 100-juice formula
• First juice with Gâc worldwide
• Pharmanex bought world supply of Gâc
  Cili(2004/2005 season)

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• will increase your scanner score!
• 4,000 7,000 units _at_ 4 fl oz / day (8 weeks)
• 12,000 20,000 units with LifePak
• Use to take LifePak!

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EFFECT OF AND OTHER JUICES ON ANTIOXIDANT
STATUS AS MEASURED BY THE BIOPHOTONIC SCANNER
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Purpose

• To compare the effects of , XanGo and
  Tahitian Noni juices on antioxidant status

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Study Design

• Subjects (N34) were randomly assigned to 1 of 3
  groups
• Subjects consumed 3 fluid oz twice per day, with
  breakfast and with dinner for 8 weeks
• Comparable Daily Intakes
• 6 fl oz (Maximum recommended intake)
• 6 fl oz Tahitian Noni (6xs Recommended dose)
• 6 fl oz XanGo (2xs Recommended dose)

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Increased Antioxidant Network Scores 9,500 in 8
Weeks
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Lipocarotenes in are More Bioavailable
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• Increased Antioxidant Scores 4xs More
  than XanGo or Noni

plt0.05 compared to wk 0 plt0.05 compared to
other juices
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Conclusions

• dramatically increases antioxidant scores.
• Lipocarotenes in g3 are 55 more easily
  absorbed.
• has 4xs the antioxidant potential of either
  XanGo or Tahitian Noni Juice.

Preliminary, unpublished data.
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Thanks to
Angela Mastaloudis, Ph.D. Associate Senior
Scientist
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Marks Business Take-aways

• Scanner Developed was developed because of
  the scanner
• SCS Certified Guaranteed to Increase Antioxidant
  Score
• Superfruit A fruit that contains unusually high
  amounts of antioxidants
• Lipocarotenes Natures unique delivery system
• First to Market Proprietary, Patent Pending,
  100 Juice, World supply of Gâc and Cili
• Tahitian Noni XanGo Lose Noni and XanGo
  lose to g3 in scanner study

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The Power of Nanotechnology

• Carsten R. Smidt, Ph.D., FACN
• Vice President, Global RD

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What is Nanotechnology?
Example Nano-Electronics
Nano-Switch

• Nanotube Wires

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A Matter of Size
Red Blood Cell
6000 nanometers
100 nanometers
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What is Nanotechnology?

• A Matter of Size 1 -100 nanometers
• Most molecules are 1 to 100 nm in size
• Function at the Molecular Level
• Nanotechnology is the science of manipulating
  substances at the molecular level

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Pharmanex Nanotechnology

• To increase intestinal uptake of poorly absorbed
  fat-soluble nutrients
• Carotenoids (lycopene, alphabeta-carotenes,
  zeaxanthin, astaxanthin)
• Coenzyme Q10

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Reasons for Poor Absorption

• Poor intestinal solubility
• Requires fat for dissolution (e.g.,
  Lipocarotenes)
• Aggregation into large particles
• not easily digested and absorbed

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The Nanotechnology Difference

• Small nano-particles are easily dispersed and
  absorbed

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NanoCoQ10
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What is CoQ10?

• Coenzyme Q10, CoQ10, or ubiquinone
• fat-soluble, vitamin-like nutrient that catalyzes
  energy production in cells
• found in all cell membranes, nuclei and
  mitochondria
• produced in the bodydecreasing with age

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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CoQ10 Health Benefits

• Helps produce cellular energy, ATP
• Provides powerful protection against free radical
  damage inside the cell (mitochondria)
• Strengthens heart muscle - supports circulation
• Maintains existing normal blood pressure
• Skin health (anti-aging benefits)

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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Regular CoQ10 Products

• Not easily absorbed into the body
• High dose needed to achieve meaningful benefits
• NanoCoQ10 uses molecular nano-encapsulation to
  significantly improve absorption

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CoQ10 Absorption by Human Intestinal Cells
300.0
5-fold increase in absorption! 30 mg 150 mg
250.0
200.0
pmol/mg protein
150.0
100.0
50.0
0.0
Chewable A
Chewable B
Chewable C
CoQ10
Nano-CoQ10
powder
powder
Preliminary, laboratory data
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Summary

• Breakthrough nanotechnology
• Highly bioavailable CoQ10
• Heart protection
• Helps produce cellular energy
• Antioxidant protection
• Use with Celltrex CoQ10 Complete
• CoQ10 PowerPack
• More at the Nu Skin workshop!

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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Introducing
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lifepak nano Nano-Antioxidants

• Nano-CoQ10

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lifepaknano Nano-Antioxidants

• New, broader-spectrum nano-carotenoid formula
• alpha-carotene
• beta-carotene
• lycopene
• lutein
• zeaxanthin (new) Eye health benefits
• astaxanthin (new) Immune response
• plus LipoNutrients (proprietary process)

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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lifepaknano Omega-3 Lipids

• Delivers MarineOmega benefits
• 600 mg EPA, 400 mg DHA
• Antarctic Krill oil
• Helps normalize omega 6/3 ratio in diet
• helps maintain normal inflammatory response
• promotes cardiovascular health
• supports brain nervous system

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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lifepaknano Vitamin E Formula

• Gamma-tocopherol
• synergistic antioxidant effects with
  alpha-tocopherol (neutralizes different free
  radicals)
• helps maintain normal inflammatory response
• New vitamin E formula in lifepak nano
• 200 IU alpha-tocopherol (134 mg)
• 75 mg gamma-tocopherol
• 26 mg beta- and delta-tocopherols
• 235 mg total vitamin E (201 mg in LifePak
  Prime)

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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lifepak nano Mineral Sources

• 600 mg Calcium, with new patented dicalcium
  malate (soluble, organic Ca)
• 300 mg Magnesium, 100 amino acid chelate
• Plus 6 other bone nutrients D, K, P, B, Si,
  resveratrol
• Advantage More efficient absorption and better
  GI tolerance than Ca and Mg in LifePak Prime or
  LifePak Women

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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lifepak nano Red Wine Actives

• 1-2 glasses of red wine a day keep the doctor
  away (French Paradox)
• Cardiovascular benefits attributed to red wine
  polyphenols
• Resveratrol
• Proanthocyanidins
• Quercetin
• lifepak nano 2 glasses red wine a day!

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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New Packet Design

• Unique 2-chamber design
• Separates soft-gels from hard shell capsules for
  optimum stability
• New film with stronger protection and oxygen
  barrier (as in LifePak Japan)

Phytonutrients
Minerals
Vitamins
proprietary CR-6 LipoNutrients
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New Health Benefits

• Helps maintain a healthy balance of pro- and
  anti-inflammatory signals (prostaglandins) in the
  body
• Cardiovascular health (designed to lower
  C-reactive protein)
• Joint health and mobility
• Expanded cell rejuvenation anti-aging benefits
• CR6-LipoNutrients, red wine benefits, 60
  antioxidants, incl. nano-antioxidants
• Complete bone support (8 nutrients)
• New eye health benefits (lutein zeaxanthin)
• Improved gastro-intestinal tolerance
• plus the benefits of LifePak Prime

Theses statements have not been evaluated by the
Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any
disease.
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lifepak nano Study
60 Antioxidants Ongoing placebo-controlled
clinical study

• 57 subjects
• 20 week study

LifePak
Placebo
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For All Adults (age 18-121)
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Cutting-Edge Science!
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Broadest Health Benefits!
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The New Dimension!
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The Power of Nanotechnology

• Visit our PRODUCT SHOWCASE!
• Win an iPod nano with lifepak nano!
• Purchase CoQ10 PowerPack and g3!

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Carstens Business Take-aways

• Nano Technology means increased absorption
• CR6-LipoNutrients Technology is proprietary and
  patent-pending
• Gentle to the stomach
• Guaranteed to increase antioxidant score
• Do You NANO?

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Now is the Time

• The FUTURE is literally in your hands and in the
  hands of the people you scan
• Joe Chang

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• Be a Champion
• 2005 Workshop