Complete 2012-13 Induced Pluripotent Stem Cell Industry Report

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Complete 2012-13 Induced Pluripotent Stem Cell
Industry Report 

• Bharat Book Bureau

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Summary

• Stem cell research and experimentation has
  been in process for well over five decades. Stem
  cells have the unique characteristics whereby
  they are able to divide and replicate repeatedly
  in addition to their being unspecialized with
  the ability to differentiate into specialized
  cell types. The possibilities that arise with the
  perfecting of cell replication has caused this
  area of exploration to remain on the forefront of
  scientific research, with ongoing hope that cures
  and treatment of diseases as well as reparative
  cell therapy, tissue regeneration and
  pharmacological testing on cell-specific tissue
  will one day become viable options within the
  medical community. Diseases such as Huntingtons
  Chorea, Parkinsons Disease, and spinal cord
  injuries are just some examples of potential
  clinical applications where stem cells can offer
  potential benefits in halting or even reversing
  medical conditions that previously had no
  positive outcome potential and induced
  pluripotent stem cells represent a preferred cell
  type for this type of disease reversal research.

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• Traditionally, scientists have worked with
  both embryonic and adult stem cells. While the
  appeal of embryonic cells has been their ability
  to differentiate into any type of cell, there has
  been significant ethical, moral and spiritual
  controversy surrounding the use of embryonic
  cells for research. Although adult stem cells can
  differentiate slightly, they are typically
  limited to differentiation within their original
  tissue type, creating narrow options for their
  use

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• Discovery
• Groundbreaking experimentation in 2006 led to
  the introduction of induced pluripotent stem
  cells (iPSC). These are adult cells which are
  isolated and then transformed into embryotic-like
  stem cells through the manipulation of gene
  expression as well as other methods. Research and
  experimentation using mouse cells at Kyoto
  University in Japan was the first instance where
  there was successful generation of the iPSC. In
  2007, a series of follow-up experiments were done
  at Kyoto University in Japan where human adult
  cells were transformed into iPSC cells.

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• While there is excitement at the prospect of
  what such artificially remanufactured cells can
  contribute to medical advances, there have been
  issues along the way which have proven to be
  prohibitive. By 2010, there were a number of
  private industries ready to capitalize on this
  breakthrough technology. One such company,
  Advanced Cell Technology in Worcester,
  Massachusetts, discovered some problematic issues
  as they conducted experiments prior to applying
  for U.S. Food and Drug Administration approval to
  utilize iPSC in therapeutic capacities. Concerns
  such as premature cell death, mutation into
  cancer cells and low proliferation rates were
  some of the problems that surfaced.

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• Research Advances
• Continued research and experimentation has
  resulted in numerous advances and triumphs over
  the last few years. According to Circulation
  Research (2012), the University of Michigan
  developed innovative methods to use bioengineered
  stem cells derived from skin biopsies to create
  cardiac muscle cells. This accomplishment has
  allowed advanced research to take place in
  treating medical therapies and drug treatments in
  diseased heart muscle.

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• Advances will continue to be perfected in the
  areas of reprogramming adult cells in appropriate
  conditions that will result in minimal negative
  outcomes. Original techniques, such as viral
  induced transcription processes, are being
  replaced with newer technology as private
  industries join with the scientific community to
  develop safe and efficient methods. With
  sustained research and experimentation,
  established guidelines related to safety and
  efficacy can be developed. Induced pluripotent
  stem cells are a promising therapy for many
  previously incurable medical diseases.

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• Market Metrics - iPSC Research Products
• For this reason a large and thriving
  research products market has grown into existence
  for this cell type. Induced pluripotent stem
  cells (iPSC) are now sold by 53.4 of U.S.
  research product companies, and 38.7 of research
  product companies worldwide. Annual growth in the
  number of iPSC research product sold worldwide
  has been growing at a rate of 14.7 per year for
  the past five years. In addition, 31 of all stem
  cell researchers identify as having using iPSC
  for a research project. It is clear that iPSC are
  a vital research trend within the scientific
  community. Therapeutic applications of iPSC are
  considered, but within the context of the
  research product opportunities these trends
  represent.

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• Perhaps the most distinctive feature of this
  report are the breakthrough findings discovered
  as a result of surveying 293 researchers that
  identify as having induced pluripotent stem cells
  as their core research focus. Of the 293
  respondents, 181 were U.S. based and 112 were
  international. These key survey findings reveal
  iPSC researcher wants and needs, technical
  preferences, and key factors influencing buying
  decisions. These vital findings can be used to
  direct the product development and product
  positioning decisions. Remember, to benefit from
  this lucrative product market, you need to
  anticipate and serve the needs of your clients,
  or your competitors will.

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• Key Findings Include
• Charts, Timelines, Metrics and Financials for the
  iPSC Research Product Market
• Trends for iPSC Grants, Publications, Patents,
  and More
• 5-Year Market Projection Data for 2012-2017
• Competitive Environment Analysis, Including
  Market Share by Competitor
• Preferred Species for iPSC Research
• iPSC Product Categories (Breakdown of Market
  Share by Each)
• Consumer Behavioral Patterns and Preferred
  Providers
• Crucial Trends and Unmet Market Needs

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• Tested Sentences for Selling to iPSC Scientists
• Trends in Marketing, Including a Breakdown of the
  Marketing Methods Used by Your Competition -
  Google Ads, Facebook Ads, App Advertising,
  Purchased Email Lists, Website Advertisements,
  Trade Journals, and More.
• End-User Wants/Needs, Technical Preferences, and
  Factors Influencing Purchasing Decisions (Survey
  of iPSC Researchers) 
• In summary, this is a must-read industry
  report for research supply companies to optimally
  position themselves to sell iPSC research
  products. To profit from this lucrative and
  rapidly expanding market, you need to understand
  your key strengths relative to the competition,
  intelligently position your products to fill gaps
  in the market place, and take advantage crucial
  iPSC trends. Claim this report now to profit from
  this expanding market- or your competition will. 

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