Avrio Medical

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Avrio Medical

• Small Heart EKG
• Arrhythmia Research Tool
• Cardiac Mapping - Microvolt Signal Acquisition
• Seddrak Luu
• George Kwei
• Jeff Chang
• Joe Ma
• Eric Chow
• Kenny Pak

2
Overview

• Business aspect
• Marketing
• Cost
• Technical aspect
• Hardware
• Software

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Arrhythmia

• Junctional Ectopic Tachycardia
• Disorders of the regular rhythmic beating of the
  heart
• Occur in children after open heart surgery
• 1 in 10 infant goes into arrhythmia after open
  heart surgery
• Can be lethal

4
The Big Picture

• understanding the patho-physiology of JET

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Goal

• a Small Heart EKG System to help understand the
  Arrhythmia
• Focus on helping those in need rather than actual
  profit

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Executive Team

• Seddrak Luu Jeff Chang Joe Ma
• George Kwei Eric Chow Kenny Pak

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BCRI Correspondence

• Dr. Glen Tibbits
• Director Cardiovascular Sciences Professor of
  Kinesiology, Simon Fraser University (SFU)
• Helen Sheng (Graduate Student, MD)
• Eric Lin (Graduate Student)

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Other Sources of Information

• Margaret Evans,
• Advanced Measurements
• Andrew Pruszynski
• Wireless Medical Devices, TA
• SFU Faculty
• School of Kinesiology/Engineering

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Structure of the Project

• Signal Retrieval Stage
• Signal Transmission
• Signal Processing
• Signal Analysis

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Avrio Core Business

• 1. Small Heart EKG
• - commercial introductions expected in a few
  years.
• Business Based on the Product
• 2. Platinum Electrode Tips
• 3. Customize Circuitry to suit the need
• 4. Customize the Labview Interface

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Business

• Current Client
• Dr. Glen Tibbits of BC Research Institute of
  Chilrdrens and Womens

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Statistics

• In British Columbia, 40,000 babies were born
• 600 babies are born with congenital heart disease
• Of that about 200 will require open heart surgery
• 1 in 10 will go into Arrhythmia
• From Statistics Canada

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Market Strategy (Short Term)

• Short Term
• Research Based Institute
• Children Hospitals and Children Research Institute

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Marketing Strategy (Long Term)

• Long Term
• Organization that supports the developing
  countries
• United Nation
• Unicef
• Engineers / Doctors Without Borders
• Aim for developing countries trying to do heart
  research with minimal budget

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Improvements

• Electrode Grid with more electrode
• Increase number of electrodes per grid
• Tailor specific small EKG and interface for
  specific customerdepending on the type of heart

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Prototype

• Total Cost 751.16
• Research 134.01
• Electrodes, Gel, Gel Pad
• Material 575.29
• Wires, Breadboard, Necessary Components
• Shipping 41.86

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Product Price for Small Heart EKG

• Component Price
• 24 x AD620 6.00
• 4 x TL072 1.00
• Capacitors / Resistors 15.00
• Wiring (Copper) 1.00
• Wiring (Platinum) 4.00
• Breadboard 20.00
• Batteries 3.00
• Miscellaneous and Casing 5.00
• NET PRODUCT PRICE 58.80
• Labour (6 hours) 72.00
• Labview Interface 39.00
• TOTAL 169.80

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Technical Aspects of Avrio Small Heart EKG
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Heart Setup

• Preparation of the heart
• Biology of the heart

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Video of the Heart

• Here we present some excerpts of the in lab
  trials of our designed device.

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Electrodes

• Initial Design Concepts/Problems
• A grid system
• Compact
• Isolated
• A flexible wrap

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Electrodes
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Electrodes

• Final Design
• Coiled platinum electrode tips
• Grounded Tin Foil Shielding
• Braided wires with metallic shielding

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Electrodes
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Challenges Incurred

• Electrode Tip
• Size Weight
• Crosstalk
• Interference
• Positioning Electrodes

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Challenge Electrode Tip

• Type of material necessary
• Amount of surface contact
• Physical spacing of electrodes
• of possible electrode tips

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Challenge Size Weight

• 2-5 grams
• 1.5x1.5x1.5 cm dimensions
• This is a very small testing area.
• We were only able to use ¼ of the heart surface
  for relevant probing data.

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Challenge Crosstalk

• Crosstalk aka additive/subtractive signals
• This is caused by close proximity of the
  electrode
• Solution
• Only preventative measures such as spacing of
  electrode tips could be used
• Future versions of systems will have software
  solution to this problem

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Challenge Interference

• Outside electrical sources such as power lines
  and light bulbs
• Most common is the 60Hz noise
• Seen from the building power lines
• Solution
• Cross braiding of the electrode leads
• A metal shielding from artificial light

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Challenge Positioning Electrodes

• Initially we hand probed the heart as an initial
  step.
• This was sufficient for testing but not very
  accurate.
• Solution
• A mounting device for the electrode bundle
• Needed to carefully hand manipulate the electrode
  tips so that they made no contact with each
  other.

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Signal Conditioning Circuitry

• Provide Gain
• Heart signal is low-milli to high-micro Volt
  range
• Filtering
• Get rid of noise from environment and other lab
  equipment

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The Circuit
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Circuit Design

• AD620 has high Input Impedance
• Low power, low cost
• -40dB Filter
• Filtering Cutoff Frequencies at 15Hz

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A/D

• National Instrument BNC-2090
• National Instrument AT-MIO-16E-10

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Labview

• Testing
• Signal Acquisition
• Signal Conditioning
• Signal Analysis

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Labview Simulating the Heart

• Generate small heart signals
• Generate background noise

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Labview Acquiring Data

• Write data to file
• Filter acquired data
• Show frequency domain

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Ischemia

• Inverted T-wave

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Bundle Branch Block

• Wide QRS Complex
• Caused by activation of the left ventricle prior
  to activation of the right ventricle

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Atrial Flutter

• Wide QRS complex
• Inverted T-wave Ischemia
• Short PR-PR intervals
• saw tooth pattern

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Bundle Branch Block

• Wide QRS Complex
• Caused by activation of the left ventricle prior
  to activation of the right ventricle

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Ventricular Tachycardia

• AV dissociation, no relationship between P-wave
  and QRS complex
• Wide QRS

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Final Comments
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Signs of Success

• We learned a lot about biology,software and
  hardware.
• We were able to obtain usable small signals that
  could be analyzed.
• Finally
• We started with 6 group members and we still have
  6 group members. YAY!

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Contacts

• Company Website www.sfu.ca/sluu/avrio
• Company Email
• ensc340-wireless_at_sfu.ca

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• Questions?
• Comments