Shared Health Research Information Network

1
Shared Health Research Information Network
Current Status, Demo, and Open Source

• Andrew McMurry, MSSHRINE ArchitectHarvard
  Medical School Center for BioMedical Informatics
• Childrens Hospital Informatics Program
  Harvard/MIT HST
• Boston University Bioinformatics PHD
  StudentAndrew_McMurry(_at_) hms.harvard.edu

2
History of the SHRINE world in 1 minute

• Partners RPDR ? i2b2 Data Repository
• Shawn Murphy et all (wont steal their thunder
  here)
• Everyday patient encounters ? huge research
  cohorts
• SPIN ? cross-hospital query model
• Extract, Transform ltde-identifiy, autocodegt, Load
  
• Federated query over multiple independent
  hospitals
• Harvard CTSA funded
• Recombinant deploying i2b2 across the country
• Overly simplified clinical data repository
  federated query SHRINE

3
SHRINE Technical Architecture

• Birds Eye View
• Leverage local i2b2 deployments
• Broadcast queries and aggregate responses across
  autonomous sites as if they were one clinical
  data warehouse
• There is no central database
• Connect sites in a peer-to-peer or hub-spoke
  fashion

4
Architecture
Technical Architecture, cell view
5
Current Status in BETA!

• East Coast Harvard Effort
• BETA system running at Harvard across BIDMC,
  Childrens, and Partners representing both BWH
  and MGH.
• Last AUG
• Prototype 1 year of data with demographics and
  diagnosis
• IRB approval for demonstration only
• NOW
• Patient data from 2001
• Demographics, Diagnosis, Medications, some Labs
• Full IRB approvals

6
Current Status in BETA!

• Demo use cases, things to think about..
• Lung cancer cases ? requesting biospecimens
• Irritable Bowel Syndrome ? requesting sized
  cohorts
• Pediatric rheumatology ? Creating national
  registry

7
Current Status

• West Coast CICTR Effort
• University of Washington
• UCSF
• UC Davis
• Nick Anderson et all

8
Current Status

• National Registry Pediatric Rheumatology
• Grand Opportunity Grant
• 60 institutions, 2 years
• SHRINE has been selected as inter-institutional
  glue
• Consented patients, prospective data collection
• Shared Virtual Machine Hosting

9
SHRINE Open Source brewing in the background

• Fast recap of 2006 and 2009 Open Source
  proposals
• Write documentation as if we are writing code
  stubs
• Preconditions
• Steps (Algorithm)
• Post-conditions Use Cases or Scenarios
• Test driven development
• Write the test first
• Implement second
• Regression test everything all the time
• Continuous Integration
• Test everything every time you change any code

10
SHRINE Open Source Process

• ? Leveraging routine development activities
• Public access to bug tracking system
• Public access to latest source code
• Public mailing lists
• Shrine-users
• Shrine-developers
• Shrine-announce
• Test Driven Development
• Continuous integration (daily builds of the
  complete software)

11
Acknowledgements Core SHRINE team

• Zak Kohane (SHRINE Lead / HMS)
• Griffin Weber (HMS CTO / bidmc)
• Shawn Murphy (I2B2 CRC / partners)
• Dan Nigrin (Childrens CIO)
• Ken Mandl (Public Health Use Cases/ CHIP IHL)
• Sussane Churchill (I2B2 Executive director)
• Doug Macfadden (HMS CBMI IT Director)
• Matvey Palchuck (Ontology Lead / HMS)
• Andrew McMurry (Architect / HMS)
• Could give an entire talk on all the
  collaborators, multi-institutional effort. Asking
  forgiveness from those not listed

12
Acknowledgements Core SPIN team

• Zak Kohane (SPIN PI / HMS)
• Frank Kuo (PSL Program Director / BWH)
• John Gilbertson (PSL Pathologist / MGH)
• Mark Boguski (PSL Pathologist / BIDMC)
• Antonio Perez (PSL Pathologist / Childrens)
• Mike Banos (PSL Developer / BWH )
• Ken Mandl (Biosurviellance PI/ Childrens)
• Clint Gilbert (Biosurviellance Dev Lead /
  Childrens)
• Greg Polumbo (SPIN Developer/ HMS)
• Ricardo Delima (SPIN Developer / NCI at HMS)
• Britt Fitch (SPIN Developer / HMS
• http//spin.chip.org/community.html

13
Acknowledgements Core I2b2 team

• https//www.i2b2.org/about/structure.html

14
Thank You

• http//catalyst.harvard.edu/shrine
• Andrew_McMurry (_at_) hms.harvard.edu