Center for Inherited Disease Research CIDR CIDR

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Center for Inherited Disease Research

• CIDR

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CIDR High-Throughput Genotyping Center for NIH
Investigators

• NIH Contract to Johns Hopkins
• established in 1996
• 52 Staff Members
• Expertise in genotyping, statistical genetics,
  bioinformatics and project management

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CIDR Services - GWAS

• Illumina Human660W-Quad Array
• Illumina Human1M-Duo Array
• Affymetrix SNP Array6.0

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CIDR Services Continued..

• Illumina Human SNP Linkage panel
• Illumina Mouse Medium Density Linkage
• Custom Genotyping
• lllumina Cancer Panel
• Illumina MHC Panel

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What CIDR Provides Investigators

• Full service not just a wet lab run
• High quality genotyping
• CIDR genotyping is free to qualifying projects

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Full Service Not Just a Wet Lab Run

• Dedicated Project Management
• SNP barcoding and sample performance pretesting
• Opportunity to replace samples
• Data cleaning

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GWAS Overall Study Statistics
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CIDR- The People
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Getting Access to Free Genotyping at CIDR

• Support of CIDR Member NIH Institute
• 2) CIDR Access Committee Approval
• Via Peer Review Process

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Institute Approval

• NCI Liaison to CIDR
• Daniela Seminara
• seminard_at_mail.nih.gov

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CIDR Access Committee Approval

• Applications are submitted as an X01
• program announcement PAR-08-258
• Submission Dates are the first weekday in March,
  July and November.

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Considerations for Access

• Evidence for a detectable genetic component
• Complexity of the trait under study and the need
  for a high-throughput genotyping
• Quality and completeness of phenotypic measures

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Considerations for Access Con..

• Appropriateness of the study design
• Power of the sample set to detect a genetic
  effect
• Plans for data analysis and data management
• Expertise of the team
• Plans for follow-up studies

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CIDR Access Committee

• Bernie Devlin (Chair) Goncalo Abecasis
• Laura Almasy Nancy Cox Lynn Jorde
• Suzanne Leal Douglas Levinson
• Deborah Meyers Gloria Petersen
• Duncan Thomas Jeffery Vance John Witte

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Summary

• CIDR is a high-throughput genotyping center that
  can generate high quality data for genetic
  studies
• CIDR genotyping is free to qualifying
  investigators
• CIDR is accessed through a peer review process
• For more information http//www.cidr.jhmi.edu/
  camilla.day_at_nih.gov