Cell Injury 1 & 2

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Cell Injury 1 2
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Slide 11Vacuolar Degeneration Kidney

• Renal tubules
• Note tiny small vacuoles
• Displaced nucleus to the side
• Glomerulus

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Slide 30Intestine Caseation Necrosis

• Casseation Necrosis - Tuberculosis -
• Irreversible injury
• Grossly like cheese soft, whitish, crumbly -
  casseous ? cassation necrosis
• Surrounded by epitheloid cells, giant cells,
  necrotic area.
• On X-ray report Fibrocasseous density
• Fibrotic center
• After treatment fibrocalcitic area/fibrotic area

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Slide 96Enzymatic Fat Necrosis (Pancreas)

• Acute hemorrhagic pancreatitis necrosis
• Exocrine function -- CHO, Fats, Lipid enzymes
• Enzymes leak out of pancreas lipase ? digests
• Peripancreatic tissue gets digested ? produced
  fatty acids, and stays in the tissue.
• Sapponified fat - see shadowy outlines of the fat
  cells, containing this. Whitish, opaque, crumbly.
• Severe abdominal pain.
• Note the following
• Normal pancreatic tissue
• Necrosis of peripancreatic fats by enzymes
  released from pancreas

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Slide (no number)Lung Abscess

• Abscess - plenty of neutrophils/enzymes
• Irreversible
• Heterolysis
• Liquifies tissue
• Pus formation
• Note
• Lung abscess digestion of lung tissue producing
  a cavity filled with neutrophils and necrotic
  material
• Alveoli with PMNs and edema

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Fatty change, liver

• Fat accumulation inside hepatocyte as colorless
  vacuoles

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Slide 50 CPC Lungs

• At pointer, antharcotic pigments (black)
• Large brownish cells ? hemosiderin-laden
  macrophages

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Slide 95 Gout

• At pointer, uric acid deposits
• Metabolic defect HPGRT deficiency
• Lesch-Nyhan syndrome

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Atheroma, Aorta

• At pointer ? cholesterol clefts at T. Intima
  layer of blood vessel

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Slide 17 Brown Atrophy, Heart

• Take note of widened interstitial spaces
• Tip of pointer ? lipofuscin pigment (light yellow)

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Slide 87Squamous Metaplasia Cervix

• Presumably rise in the endocervical glands
• Have mixed glandular and squamous patterns that
  may have arised from reserved cells in the basal
  layer of the endocervical epithelium

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Thyroid Hyperplasia(no slide number)

• Increased size of lining epithelium

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Slide 42 Villous Adenoma, colon

• Pointer ? portion of the stalk

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Cavernous Hemangioma(slide 155)

• Most common benign lesion
• Chief clinical significance should not be
  mistaken for metastatic tumors in radiological
  studies.
• Less common than capillary hemangioma

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Slide 68 Dermoid Cyst 1

• Benign mature teratoma ovary

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Slide Dermoid Cyst 2

• Benign mature teratoma ovary
• Similar to the epidermal inclusion cyst, but also
  shows appendages such hair follicles.

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Slide 67Leiomyoma, Uterus

• Benign, well differentiated tumor contains
  interlacing bundles of neoplastic smooth muscle
  cells.
• Virtually identical in appearance to the normal
  smooth muscle cells in the myometrium
• Whirling appearance

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Slide 133 Thyroid Adenoma

• Irregularly shaped capsule
• Neoplastic cells are demarcated from parenchyma
  by well-defined, intact capsule.
• (page 265, figure 8-6)

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