Red blood cells destruction

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Red blood cells destruction

• Prof lammers
• Week 1
• Hematology Immunology Module

4MedStudents.com
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What happens when RBCs are destroyed?

• When RBC age, they are engulfed by macrophages.
• RBC destructed to several products
• 1- Fe in the form of transferin and ferritin.
• 2-Globulin that is broken down to simple amino
  acids and are reused
• 3- Heam that is converted to billiverdin

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Consequences of heam destruction abnormality

• Jaundice is the main presentation of
  abnormalities in heam destruction
• When billirubin is high gtgtgt Jaundice
• If unconjugated billirubin is high
• Hemolytic anemia gtgtgt increase RBC destruction.
• If conjugated billirubin is high
• Obstructive bile duct
• Liver disease

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Reaction of the body to bleeding

• 1- Vasoconstriction of the veins of the least
  essential organs. Such as GIT, Kidney, skin
  (from least essential) and the most essential
  organ is the brain.
• 2- Fluid shift flow of fluids from the
  extracellular space to the blood by increasing
  blood return to capillaries in comparison to
  blood loss to tissue

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Normal fluid shift
Arterial end
venous end
NFR -5
NFR 5
Hydrostatic pressure
oncotic pressure
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Fluid shift in bleeding
Arterial end
venous end
10
20 Hydrostatic pressure
Hydrostatic pressure
25
25 oncotic pressure
oncotic pressure
Tissue
The hydrostatic pressure decreases because of
decrease in blood volume due to bleeding