Ibogaine and cellular metabolism

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Ibogaine and cellular metabolism
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Traditional use of Iboga

• enteogen - ritual drug
• oneirogen - awake dreams
• psychostimulant and tonic
• reconvalescence after infectious diseases
• aphrodisiac

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Use of Iboga/ibogaine in the West

• interruption of addiction to alcohol, opiates,
  nicotine in cocaine
• spiritual growth and self-realization
• holly sacrament
• use at extreme sports
• mountaineering
• interesting for army

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Ibogaine in medicine

• 1905 1030mg per day against asthenia
• 1939-1970 neuromuscular stimulant 8mg per pill
  against fatigue, depression and at
  reconvalescence after infectious diseases
• 1969 4-5mg/kg as fantasy enhancer at
  psychotherapy

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Pharmacodynamics of ibogaine

• immediate (acute) effect
• prolonged effect

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Pharmacodynamics of ibogaine

• effects last longer than the presence of ibogaine
  in the body
• fat deposits of lipophillic metabolite cannot
  directly cause the effect for weeks or months
• functional and structural changes are expected

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Composition of cell

• nucleic acids
• proteins
• polysaccharides
• lipids
• water

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Proteins

• structural
• functional

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Structural proteins-cytoskeleton
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Functional proteins-receptor
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Functional proteins-enzyme
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Protein separation by 2-D electrophoresis
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Computer scan of gel
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Computer scan of gel
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In silico analysis of results
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Spots of interest
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Peptide mapping by mass spectrometry
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Identification of proteins by matching with data
bases
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Induction of energy metabolism related enzymes in
rat brain
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Induction of energy metabolism related enzymes
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Nonspecific activation of metabolism
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Interpretation of results

• Enhanced energy availability supports higher
  metabolic turnover and by that facilitates
  detoxification and renewal of tissues.
• Besides, consequent mental agility provides
  insight into ones own psychological state

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Aura and ibogaine

• -40 min

3 h
54 h
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Aura and ibogaine
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Aura and ibogaine thantanosis
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Aura and ibogaine
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Aura and ibogaine
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Aura and ibogaine
Maybe illumination and revelation are proper
words to describe what is at this moment
difficult to explain
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Pharmacodynamics of Entheogen Drugs - Influence
on Gene Expression

• - Faculty of Pharmacy, UL
• - Biotechnical Faculty, UL
• - Faculty of Medicine, UL
• - Faculte de Pharmacie,
• Universite Montpellier 1,
• Montpellier, France
• - Institute for Biological
• Research Sinia Stankovic,
• Belgrade, Serbia

OMI,Institute of Anthropological Medicine

www.omi.si