Title: CAM You can Use: Preventing Headaches
1CAM You can Use Preventing Headaches
- Kathi J Kemper, MD, MPH
- General Pediatrics, Integrative Medicine
- 2nd Opinion Clinic (Monday mornings)
- kkemper_at_wfubmc.edu
- 716-9640
2Disclaimer
- I have no conflicts of interest to report
regarding this presentation I published a CME
article on this topic with MedScape for which my
institution received payment - The presentation includes no description of any
proprietary items for screening, diagnosis, or
treatments
3Objectives
- By the end of this session, participants will be
able to - Counsel patients on dietary modifications to
prevent headaches - Discuss the scientific evidence about the
effectiveness of stress management practices in
preventing headaches - Find evidence-based resources about the
effectiveness of acupuncture in preventing
headaches (See AAP Section for Complementary and
Integrative Medicine join the listserv) - NOT focused on diagnosis or medications
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5Headache
- Common! (in teens, gt 4 HA in past month by 6
males 14 females) (Linet. JAMA, 1989) - 90 Migraine or Tension-Type Headache
- 10 other sinusitis, eye, trauma, ice cream,
cervicogenic, myofascial pain, TMJ, hemorrhage,
infection, pseudotumor, vasculitis, tumor,
6CAM Use for Tension-Type HA
- 40 used CAM
- 60 did not tell MD (how many MDs asked?)
- Types of CAM
- Chiropractic 21
- Acupuncture 17
- Massage 17
- Rossi et al. Headache 46622-631, 2006
CAM Complementary or Alternative Medicine,
somewhat outdated and useless term
7CAM at UNC for Headache
- Biofeedback (thermal, muscular, heart rate
variability, autonomic) - Hypnotherapy
- Osteopathy
- Acupuncture
- Mindfulness Meditation
- Herbal and supplement counseling
8Prevention options
Bioenergetic
Patient-Centered Care
Biomechanical
Biochemical
LIFESTYLE
9Prevention/health promotion lifestyle
- Avoid triggers!
- Nutrition and supplements
- Exercise/sleep
- Environment
- Stress management
10Lifestyle AVOID TRIGGERS
- Non-modifiable genetics, gender, weather
- Semi-modifiable air pollution (including tobacco
smoke, CO, SO2, NO2), menses - Modifiable
- - Lack of sleep
- - Missing meals
- Allergens
- Foods tyramine containing, nuts, cheese, smoked
fish, artificial sweeteners, nitrate
preservatives, MSG, caffeine withdrawal - Stress physical, psychological
- !!KEEP A HEADACHE DIARY!!
11Diet Avoid Food Allergens
- Clinical trial of 43 patients
- Allergy skin testing
- 69 responded to diet modification (plt0.005)
- People with IgE-specific food allergy benefited
more from the elimination diet than people with
negative skin tests.
Mansfield L et al.. Ann Allergy, 2004
12Diet and Migraine
- Regularization of meals
- Normalize blood sugar (glycemic index)
- Elimination Diet 1 Caffeine, cheese, nuts,
chocolate, shellfish, onions, aspartame, wine,
beer, dairy, processed meats - Elimination Diet 2 Lamb and rice add back
- Reduction in omega-6 fatty acids red meats,
fast food - Increase in omega-3 fatty acid intake-fish oil
13Dietary Supplements
- B vitamins
- Minerals calcium, magnesium
- Fatty acids/fish oil
- CoQ10
- Melatonin
14Supplements B vitamins
- B2
- Migraine sufferers suspected of having a
mitochondrial defect -gt impaired O2 utilization - Riboflavin (B2) is the precursor to key molecules
in the electron transport chain in the
mitochondria - 200 mg BID with meals for 3 months -gt 68
reduction in migraine attacks in RCT (next slide) - Side effect yellow urine
- Schoenen. Neurology, 1998 Sandor. Headache,
2000 Magis. Headache, 2007 - B6 essential in converting tryp to serotonin
- More than 100 mg daily -gt nausea, abd pain,
sleepiness, lower B12 levels gt1000 mg daily -gt
sensory neuropathy
15 High Dose Riboflavin vs. Placebo
Schoenen J et al. Effectiveness of high-dose
riboflavin in migraine prophylaxis a randomized
controlled trial. Neurology 50(2) 466-70 1998.
16Supplements Minerals
- Calcium for PMS-related migraines
- 44 of boys and 58 of girls 6-11 insuff
- 64 of boys and 87 of girls 12-19 insuff
- Ensure 1200- 1500 mg daily
- Thys-Jacobs. J Am Coll Nutr, 2000
- Magnesium (1 gram iv acutely) or 300 500 mg
daily po to prevent (soy beans, black beans,
tofu, seeds, nuts, whole grains, shellfish) - Mauskop. Headache, 2002 Pfaffenrath.
Cephalgia, 1996 - Mazzotta. Cephalgia, 1999 Wang, Headache, 2003
- Peikert. Cephalgia, 1996 Facchinetti F,
Headache, 1991
17 Magnesium - mechanism
- Ionized magnesium levels low in 50 of MHA
patients - Migraines associated with platelet aggregation,
serotonin release - Magnesium reduces platelet aggregation
- Magnesium decreases the affinity of serotonin for
vascular receptor sites - Magnesium acts as an NMDA receptor (glutamate
receptor) antagonist - NMDA receptors pain transmission
- Inhibits one type of neuronal spreading
depression in experimental models - OPTIONAL SLIDE for participant reference
18 Consequences of Reduced Mg
- Vasoconstriction of scalp arteries
- Reduced affinity of serotonin receptors
- Lower threshold for activation of
N-methyl- d-aspartate receptors - Enhanced platelet aggregation and serotonin
release
19 Trials with Mg Supplements
- An infusion of 1.0 g of magnesium sulfate in 40
patients with acute migraine - 52 responded to therapy
- 86 of the responders had low serum ionized Mg
levels - 16 of the non-responders had low serum ionized
Mg levels.
Mauskop A. Alternative therapies in headache Is
there a role? Medical Clinics of North America
85(4) 1077-84 2001.
20 Trials with Mg Supplements
- Four trials with oral magnesium supplementation
- Three of the four showed efficacy
- The one negative trial used a poorly absorbed
magnesium salt which resulted in diarrhea
21Current Use of Mg Supplements
- 500 mg/day K Mg aspartate
- Avoid combining with Fe, Ca, Zn
- May cause temporary diarrhea
- Magnesium gluconate an alternate
- Menstrual migraine months to benefit
Mann, Doug et al. Migraine and Tension-Type
Headache. Integrative Medicine. Ed. David Rackel
MD. Philadelphia Sanders, 2006 143-156.
22Omega-6 Fatty Acids
Omega-3 Fatty Acids
Linoleic Acid (182n-6)
a-Linolenic Acid (183n-3)
?-6 Desaturase
(GLA)? -Linolenic Acid (183n-6)
Stearidonic Acid (184n-3)
Elongase
(DHGLA) Dihomo-?-Linolenic Acid (203n-6)
Eicosatetraenoic Acid (204n-3)
?-5 Desaturase
Eicosanoids
(AA)Arachidonic Acid (204n-6)
(EPA) Eicosapentaenoic Acid (205n-3)
Elongase
245n-3
Eicosanoids Leukotriene 5-series Prostaglandins
E3 Thromboxanes A3
?-6 Desaturase
Eicosanoids Leukotriene 4-series Prostaglandins
E2 Thromboxanes A2
246n-3
ß-Oxidation
(DHA) Docosahexaenoic Acid (226n-3)
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24Changing Fatty Acid IntakeOmega 6 Omega 3
n-6 fats n-3 fats
- Prehistoric 1900 2000
- 11 41 251
25Why EFA Imbalance in US?
- Diet is high in Omega-6 and low in Omega-3
(previously 11 ratio, now 201) - Hydrogenated oils
- Enzyme cofactor deficiency (B-3, B-6, Biotin, C,
Zinc, Magnesium) - Genetic polymorphism (biochemical individuality)
- Hyperinsulinism from high glycemic load diet
(increase DGLA to AA) - Increased stress -gt increased demands.
26Fatty acids Omega 3s
- Popular approach to decreasing inflammation
- Open studies suggest it helps reduce headaches
doses 1-3 grams daily - RCTs mixed results olive oil may not be a
placebo! - Supplements generally free from mercury,
dioxins, PCBs palatable - Harel. J Adolesc Health, 2002
- Pradalier. Cephalgia, 2001
- Puel. Br J Nutr, 2004
27Coenzyme Q-10
- Open label, 150 mg qd - for 3 months
- 62 had gt 50 reduction in number of HA days
- Migraine Days 7.34 -gt 2.95/mo
- Frequency 4.85 -gt 2.81/month
- No side effects except pain in pocketbook
- Rozen and Silberstein, Cephalalgia 22 137-141,
2002
28Melatonin and Headache
- Mechanism
- Potentiates GABA Modulates Ca entry in to
vascular smooth muscle cells - Modulates 5HT2 receptor like B- blockers
Inhibits the synthesis of prostaglandin E2 -
inflammation mediator - Melatonin low and out of phase in menstrual
migraine, chronic daily headache, migraine,
status and cluster HA - Effective preventive for cluster HA and HA
associated with delayed sleep-phase syndrome
29Melatonin Sleep phase delay or cluster HA
- Corrects delayed sleep-phase syndrome
- An alternative to benzodiazepines
- Dosing 6-12 mg one hour before bed
- Few side effects
- ConsumerLab reviews show consistent quality
- Rozen. Headache, 2006
- Vogler. CNS Drugs, 2006
- Rozen, Neurology, 2003
- Pringsheim. Headache, 2002
- Miano. Neurol Sci, 2008 PEDIATRIC STUDY
30Lifestyle Stress management
- Stress is common
- Stress triggers/worsens pain
- Managing stress exercise, sleep, nutrition,
mind/emotion/body/spirit - Biofeedback
- Hypnosis
- Reducing stress helps 50 - 70 of headache
sufferers
31The Many Forms of Mind-Body Medicine
32Stress and Physiological Activation
High Arousal/High Energy SYMPATHETIC
Low Arousal/Low Energy
PARASYMPATHETIC
Institute of HeartMath
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34Biofeedback-What and why?
- Use of electronic equipment to measure and feed
back information about physiologic
functionswhich are then modulated in desirable
direction - Goal-balancing ANS ( CNS) activity
- video-games for your body kid-friendly
- 2007 meta-analysis showed gt 50 controlled trials
of BF for HA EFFECTIVE! - Strong treatment effect that persists for over 12
months after training - Allen Pediatr Ann, 2004
- Kaushik R. Complement Ther Health Med, 2005
- Trautman. Cephalgia, 2006
- Nestoriuc. Pain, 2007
35Biofeedback - Example
- Blanchard - 116 patients with migraine
- Assigned to either thermal biofeedback, thermal
biofeedback with relaxation training, or
pseudomeditation, headache monitoring - Six month follow-up
- 51 of the subjects in the thermal biofeedback
groups improved in frequency compared to 5 and
22 for the monitoring and pseudomeditation
groups
Blanchard E et al.. J Consult Clin Psychol 1990.
36Biofeedback Modalities
- Home or Office Use
- Peripheral Temperature
- Heart Rate Variability
- Surface EMG
- Skin Conductance
37Biofeedback-Temperature
- Theory-the more relaxed, the lower sympathetic
nervous system activity, the more peripheral
blood flow, hands and feet warm up - Resources
- Dermatherm Bands Sharn, Incorporated
www.sharn.com - BioDots
- www.futurehealth.org
- www.cliving.org
- Digital Temp Portable Units
- www.Bio-medical.com
- www.thoughttechnology.com
38Heart Rate Variability (HRV)
2
1.5
76 BPM
83 BPM
70 BPM
m Volts
1
.793 sec.
.726 sec.
.859 sec.
0.5
0
-0.5
0
1
2
2.5 seconds of heart beat data
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40Hypnosis/Guided Imagery
- Hypnosis An altered state of awareness usually
but not always involving relaxation during which
the participant can give himself/herself
suggestions for desired changes to which he/she
is more likely to respond that in their usual
state of awareness. - Guided Imagery A technique that involves using
the imagination and mental images to promote
relaxation, changes in attitude or behavior, and
encourages physical healing. AKA- visualization.
41Children Enjoy It
- To teach self hypnosis for a specific purpose
(such as reduction of pain or elimination of a
habit) involves helping young children focus on
their natural thinking styles. - Kids move in and out of altered states and
imaginary activities all the time. Think
IMAGINARY PLAY! - The child is in control.
- We serve as the teacher or coach.
- Offer choices and options.
- The child can use this skill when he or she
chooses. - Ask that parents not remind the child to practice
self hypnosis its up to the child/adolescent
42Hypnosis Prevention
- Meta-analysis strong evidence of benefits for
tension HA (Hammond. Int J Clin Exp Hypnosis,
2007) - Better than wait-listed controls for migraine
prevention (Melis. Headache, 1991) - Superior to propranolol or placebo in juvenile
classic migraine prevention (next slide)
43Hypnosis Headache
- Children 6 to 12 years with classic migraine
- RXT propanolol vs. placebo for 3 months each
- Then hypnosis training
- Placebo 13.3 HA/ 3 mos
- Propanolol 14.9 HA/3 mos
- Hypnosis 5.8 HA/3 mos (Plt0.05)
- Olness. Pediatrics. 1987
- Hammond Int J Clin Exp Hypn. 2007
44 Hypnosis Misconceptions
- Patient is under control of the hypnotherapist
- Patient is unaware of surroundings and/or
activities around him/her - Patients defenses are impaired (there is improved
access to subconscious material) - Symptoms are masked
- Patient can be forced to do things they would not
normally do
45Contraindications to Hypnosis
- Ignoring underlying disorder
- Used for fun or entertainment
- The problem is more effectively treated with
another modality - Patient is psychotic, acutely depressed
- Patient (child) does not want to engage in
hypnosis (but parent wants them to)
46Mind-Body Autogenic Training
- Form of hypnosis
- Repeat phrases
- My hands and arms are heavy and warm
- My legs and feet are heavy and warm
- My heartbeat is calm and regular
- My breathing is easy and free
- My forehead is cool
- My belly is relaxed
- Reduces need for headache medication
- Reduces frequency of migraine attacks
- Zsombok. Headache, 2003
- Juhasz. Headache, 2007
47Massage for Migraines
- Massage improves blood flow and decreases
inflammation, relaxes muscles, reduces stress,
provides tangible social support - Can combine with physical therapies such as ice,
heat aromas (peppermint) - RCT for migraines showed significantly decreased
frequency and improved sleep - Lawler SP. Ann Behav Med, 2006
- Pieovesan. Arq Neuropsiquiatr, 2007
48Chiropractic
- Commonly used
- Older studies support use of chiropractic in
migraine frequency and severity were reduced - Little other evidence supporting use in headache
of different types - Tuchin. Australas Chiropr Osteopathy, 1997
- Parker. Aust NZ J Med, 1978
49Osteopathy - Headache
- Five of six studies showed positive results for
tension, cervicogenic and post-traumatic HA - No studies specifically for migraine
- No control groups or long term results
- Two of 6 studies results comparable to TCA
- Hoyt. J Am Osteopath Assoc, 1979
- Fernandez-de-las-Penas. J Orthop Sports Phys
Ther, 2006 - Bronfort. J Manipulative Phys Ther, 2001
50Acupuncture for Chronic Daily Headache UNC
study
- RCT of usual medical care (UMC) vs UMC
acupuncture - Medical care alone no change
- Medical care acupuncture
- Improvement in headache impact (function)
- Improvement in general mental health domains
(SF-36) - 3.7 times gtlikely to report reduced suffering
- Coeytaux R. Headache, 2005
- Gottschling. Pain, 2008 PEDIATRIC STUDY LASER
ACUP. - Witt. Cephalgia, 2008 COST EFFECTIVENESS
51Acupuncture Mechanism of Action
- The documented effects of acupuncture include
- 1) Release of opioids in the central nervous
system - 2) Changes in regulation of blood flow, blood
pressure, body temperature, and alterations in
immune function.
52Mechanism of Action
- Functional MRI Single point stimulation
- Activation of occipital lobes with lateral foot
VA1 stimulation - Reduction in limbic structure activity with true
acupuncture (pressure sensation) - Activation of somatosensory cortex with sham
point activation or painful response to needling
53Mechanism of Action Biomedicine
- Release of opioid-like substances into CSF
- Substance P, neurokinin A, neuropeptide Y
- Serotonergic and dopaminergic systems activated
- Descending pain inhibitory systems activated
- Thalamic relay nuclei inhibition
- Dorsal root entry zone inhibition
54Acupuncture for Headache
- 5 or more weekly 20-40 minute sessions
- Electrical stimulation
- Prolonged benefit after 6-10 weeks
- 70 respond to acupuncture -frequency
Morrisey, H et al. Headache 43, 221-228, 2003
55Acupuncture
Vincent C. A controlled trial of the treatment of
migraine by acupuncture. Clinical Journal of
Pain. 5(4) 305-12 1989.
56Acupuncture Migraine Reviews involving gt 1000
patients
- Acupuncture benefits adults and pediatric
patients in preventing migraines - NOT for acute treatment
- 1-2 treatments weekly for 4-6 weeks
- Effects last at least 6 months
- Side effects rare
- Melchart et al. Cephalalgia, 1999
- Manias.The Clinical Journal of Pain, 2000
57Healing Touch And Therapeutic Touch
58Biofield Therapies
- Rapid increase in use and availability of Healing
Touch, Therapeutic Touch, Reiki, QiGong, Polarity
Therapy - RCT showed decreased tension headache pain with
TT - Keller E. Nurs Res, 1986
59Herbs In Migraine
- Feverfew yes for prevention if you can get
British and use it daily - Valerian to help with sleep
- Petasites (Butterbur) yes for prevention if you
can get quality product
60 Feverfew
- Feverfew (Tanacetum parthenium)
- 270 adult migraine patients
- 70 reduction in intensity and frequency of
migraine - Other trials have not been as promising but all
show benefit of feverfew gt placebo - Variability in quality of products!
- Murphy J et al.. Lancet 1988.
- Ernst E et al.. Public Health Nutrition .2000.
61Feverfew
- Significant reduction in frequency, not in
duration - No head to head studies with other modalities
- Dosing 125mg/day of the dried leaf standardized
to a minimum 0.2 parthenolide - Maximum effect after 4-6 weeks
- Adverse effects Aphthous ulcers and
gastrointestinal side effects in 5-15 - Avoid abrupt cessation agitation increased HA
- Contraindicated during pregnancy
62Valerian
- Used for sleep, anxiety
- 150-300 mg of dried root hs or tid
- Few side effects
- Avoid prolonged use rebound headache
- Used during headache
- Smells very bad
63Petasites hybridus Root Extract
- Large, 3arm, dose-finding RCT (Lipton,
Neurology, 2004) - Reduced frequency by more than 50 in 68 of
those with highest doses. - Few dropouts.
- Two other confirmatory studies, one in children.
64RESOURCES
- Acupressure / acupuncture
- Self care
- Hypnosis
- Biofeedback
65Acupressure resources
- www.omsmedical.com (supplies)
- www.auricularacupuncturecollege.com
- www.khtsystems.com (korean hand acu)
- www.hmieducation.com (Helms course)
- www.aaaom.org (training and certification)
- www.acupressure.com (resources)
66 HRV Biofeedback - Resources
- www.heartmath.com (products and training)
- www.heartmath.org (research)
- www.aapb.org
- www.stresseraser.com
- www.bcia.org
- www.stens-biofeedback.com
- www.wildDivine.com
67Self-Care Training Resources
- Books
- Be the Boss of Your Body Series
- www.freespirit.com
- Ways to Wellness Videos
- http//www.childrensmn.org/Communities/Integrative
Med.asp - Music and Recorded Relaxation Exercises
- www.therelaxationcompany.com
- www.healthjourneys.com
- www.Pzizz.com
- Home Computer Biofeedback Fun
- www.wilddivine.com
- www.heartmath.com
68Web Resources
- AAP Section on CHIM
- www.aap.org/sections/CHIM
- Will post this presentation
- Integrative Pediatrics Council
- www.integrativepeds.org
- CAM bibliography
- IPC Network
69Training and Certification
- Society For Developmental and Behavioral
Pediatrics Annual Pediatric Hypnosis Training - American Society for Clinical Hypnosis
- Society for Clinical and Experimental Hypnosis
- International Society for Hypnosis
- Academy for Guided Imagery
70Text Resources
- Culbert Olness, ed Integrative Pediatrics
- In press, March 2009 (Oxford University Press)
- Loo Integrative Medicine for Children (2008)
- Rosen Riley, ed Complementary and Alternative
Medicine, Pediatric Clinics of North America
(December 2007) - Schwartz Andrasik Biofeedback A Practitioners
Guide - Shannon Handbook of Complementary and
Alternative Therapies in Mental Health - Schnaubelt Medical Aromatherapy
- Reed Gach Acupressure Potent Points
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73PCIM Director Kemper
Medical School Arcury (Family Med) Avis (Public
Health) Chilton (Phys/Pharm) Curl
(Orthopedics) Tegeler (Neurology) Stant
newsletter/Web
Hospital Atkinson (Business Dev.) Johnson
(Operations/Nursing) Parker (Home
Community) Small (Quality) Snelgrove
(Operations) Yates (Pastoral Care) Zachary
(meetings)
74Program leaders Bailey Ambience Sound/Music Best
Health Black ActionHealth/ Farmers
Market Dailey/McCarty Meditation Danhauer
Yoga Feldman Guided imagery Kilbourne Green
Initiative LaRose HM Hospital Larrimore
Healing Touch/HeartMath McClenny Arts Melcher
Massage NW Area Health Education Center Pashayan
Hypnosis Sackett RN Research Wilson
Recreation/Aqua Woodard - Nutrition Zachary
Healthy Living Julie Milunic Advisory
Board Library Staff resources Mark Wright PR
and Marketing
Hospital
Medical School
75How Behavioral Medicine
- Identify the goal
- Consider various strategies
- Pick a strategy
- Identify a small, achievable step that the
patient and family can support - Explore pros and cons of change
- Anticipate barriers identify resources
- Plan rewards/celebrations!
- Re-evaluate take the next step
76Goal-setting
- Pick a POSITIVE goal
- E.g., healthier lifestyle.
77Example Healthier lifestyle
- To promote
- Better mood
- Better focus or concentration
- Greater calm More resilience
- More cheerfulness Greater adaptability
- More confidence More creative
- More clarity
- Better memory
- More harmonious relationships
- Higher self esteem
- More consistent with personal values
- other?
78Pick a specific strategy
- More exercise
- Better nutrition
- Judicious use of supplements
- Better sleep
- Healthier environment
- Stress management biofeedback journal
meditation - Use medication
- Massage, psychotherapy, acupuncture or other
professional help
79Identify a small, achievable step
- Rome was not built in a day habits are not
changed overnight BABY STEPS. - For exercise, go from sedentary, to 5 minute
walks with the dog 5 days a week. - Be specific (with or without an MP3 player with
or without a friend regardless of weather?
distance vs. time)
80How important is this to you?
- 0 1 2 3 4 5 6 7 8 9 10
- Not Very
- Why did you pick that number and not a lower
number? (e.g. a 7 instead of a 5) - Asking this question helps the patient/family
provide their own rationale for why this is
important. They talk themselves into it!
81How confident are you that you can do this for
one month?
- 0 1 2 3 4 5 6 7 8 9 10
- Not Very
- If they pick an 8 or higher (pretty confident),
proceed with next step of making a chart and
planning rewards and follow-up. - If they pick a number less than 8,
- What would it take for you to go from the number
you picked to a higher number? Begin to explore
their ambivalence. Its OK to be ambivalent
about change!
82Identify Pros and Cons
83Identify Barriers and Resources
- In addition to (cons listed above), what other
barriers or challenges might you anticipate as
you try to make this change? Need new tennis
shoes need leash need pooper-scooper - What resources do you have/need to help you make
this change? Will Mom commit to getting new
shoes, leash, etc. ? Will the child want/need a
reminder? Is it helpful for Dad to do that? Do
they need a chore chart? A calendar?
84Plan celebrations/rewards
- Pick a tangible reward and timing (will it be
offered after week 1, 2, 3, 4?) - Samples new walking shoes Support the patients
choices. - Emphasize the importance of the
reward/celebration. If the patient says they
expect good behavior, suggest they consider
celebrating it (instead of rewarding it).
85Sample behavior diary (OK to copy)
86Follow Up
- Follow- up in 4-6 weeks.
- Ask patient to bring chart and say you plan to be
proud of them (build expectation of success) and
will ask them what theyd like to do for next
step (involve them in problem solving). - Do it!
87Behavioral Medicine
- Identify the goal
- Consider various strategies
- Pick a strategy
- Identify a small, achievable step that the
patient can embrace - Explore pros and cons of change
- Anticipate barriers identify resources
- Plan rewards/celebrations!
- Re-evaluate take the next step